Inosine

DRUG10 trials

Conditions

Amyotrophic Lateral SclerosisHealthyHealthy VolunteersMultiple Sclerosis, Relapsing-RemittingParkinson DiseaseParkinson's DiseaseParkinson's Disease (PD)Superficial Siderosis

Phase 1

A Pilot Study of Inosine in Amyotrophic Lateral Sclerosis (ALS)

CompletedNCT02288091

Massachusetts General HospitalAmyotrophic Lateral Sclerosis

Start: 2015-01-31End: 2016-03-31Updated: 2017-11-06

A Food-Drug Interaction Study of Serum Urate After Oral Inosine

CompletedNCT02614469

Michael Alan SchwarzschildHealthy

Start: 2015-03-31End: 2016-05-31Updated: 2017-03-29

A Phase Ib Trial of Combined Febuxostat and Inosine Therapy in Patients With Parkinson's Disease

RecruitingNCT07170475

Fujita Health UniversityParkinson's Disease (PD)

Start: 2025-06-27End: 2026-07-31Target: 24Updated: 2025-09-12

Phase 2

Treatment of Multiple Sclerosis Using Over the Counter Inosine

CompletedNCT00067327

National Center for Complementary and Integrative Health (NCCIH)Multiple Sclerosis, Relapsing-Remitting

Start: 2002-02-28End: 2005-09-30Target: 30Updated: 2006-03-17

Safety of Urate Elevation in Parkinson's Disease

CompletedNCT00833690

The Parkinson Study GroupParkinson Disease

Start: 2009-06-30End: 2012-12-31Updated: 2014-06-05

Safety of Urate Elevation in Amyotrophic Lateral Sclerosis (ALS)

CompletedNCT03168711

Massachusetts General HospitalAmyotrophic Lateral Sclerosis

Start: 2017-10-01End: 2020-01-07Updated: 2021-02-18

Inosine Reverse Chemo Resistance in Triple Negative Breast Cancer

CompletedNCT06355024

Fudan UniversityTriple-negative Breast Cancer

Start: 2024-05-11End: 2025-01-01Updated: 2025-07-18

Phase 3

Study of Urate Elevation in Parkinson's Disease, Phase 3

CompletedNCT02642393

Michael Alan SchwarzschildParkinson's Disease

Start: 2016-06-30End: 2019-06-30Updated: 2020-07-28

Unknown Phase

Inosine Energy Expenditure Study

CompletedNCT04476238

University Hospital, Basel, SwitzerlandHealthy Volunteers

Start: 2022-02-28End: 2023-04-30Updated: 2023-09-28

Therapeutic Antioxidant Supplementation

Not yet recruitingNCT04890808

Superficial Siderosis Research Alliance Inc.Superficial Siderosis

Start: 2023-05-31End: 2027-09-30Target: 50Updated: 2022-05-05

JMIR Research Protocols2025-07-07

Improving Prediction of Falls and Cognitive Impairment in Parkinson Disease: Protocol for a Decentralized Observational Study (Preprint)

2025-02-03

Enrollment of Participants From Marginalized Racial and Ethnic Groups

Neurology Clinical Practice2023-01-1814 citations

Using Smartphones to Reduce Research Burden in a Neurodegenerative Population and Assessing Participant Adherence: A Randomized Clinical Trial and Two Observational Studies

JMIR mhealth and uhealth2022-02-0424 citations

Effect of Urate-Elevating Inosine on Early Parkinson Disease Progression

JAMA2021-09-14151 citations

Expectations of Benefit in a Trial of a Candidate Disease‐Modifying Treatment for Parkinson Disease

Movement Disorders2021-05-046 citations

Sex differences by design and outcome in the Safety of Urate Elevation in PD (SURE-PD) trial.

2019-09-0432 citations

Time to reconsider urate: Neuroprotective potential may prevail on cardiovascular risk in animal models and clinical trials

EBioMedicine2018-11-015 citations

Inosine to Increase Serum and Cerebrospinal Fluid Urate in Parkinson Disease

JAMA Neurology2014-02-01235 citations