Aging
Conditions
Brief summary
We need better tools to both enhance brain health and improve cognitive performance in healthy brain aging so that it can be delayed, reduced, or even reversed. The present proposal is designed to evaluate the pairing of cognitive training with a non-invasive neurostimulation technology that has shown promise in both increasing neuroplasticity and in enhancing cognitive performance, transcutaneous vagal nerve stimulation (tVNS).
Interventions
a non-invasive and safe technique that transiently enhances brain GABA and noradrenaline levels.
BEHAVIORALcognitive training
A program of regular mental activities purported to maintain or improve one's cognitive abilities.
Sponsors
University of Arizona
University of Florida
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
65 Years to 90 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy individuals willing to commit to study requirements
Exclusion criteria
* Neurological disorders to include traumatic brain injury. * Evidence of dementia . * Major psychiatric illness * Unstable and chronic medical conditions. * MRI contraindications (e.g., pregnancy, claustrophobia, metal implants that are contraindicated for MRI). * Physical impairment precluding motor response or lying still or walking * Hearing or vision deficits that will not allow for completion of assessments
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in working memory and processing speed contributors | Baseline to 2 weeks | The Posit Science BrainHQ |
Countries
United States
Outcome results
None listed