Diabetes Mellitus, Obesity
Conditions
Brief summary
To investigate the effects of rice polishing on glycaemic and insulinaemic response in healthy Chinese male volunteers.
Detailed description
There will be a total of 8 test session. Each session will last for 3.5 hours. At each test session, volunteers will be served with test meal and blood will be collected. After an overnight fast, subjects will visit the research center. Two fasting capillary blood samples will be collected via fingerprick. Following the fasting samples, subject will consume the test meals. Further blood samples will be collected at 15, 30, 45, 60, 90, 120, 150, 180 minutes after the ingestion of test meal. These samples will be used to analyses for whole capillary blood glucose. At every 30 minute interval, samples will be collected for analysis of capillary plasma insulin.
Interventions
OTHERGlucose Reference 1
50 g of glucose dissolved in 250 ml of water (First glucose control visit)
OTHERGlucose Reference 2
50 g of glucose dissolved in 250 ml of water (Second glucose control visit)
OTHERGlucose Reference 3
50 g of glucose dissolved in 250 ml of water (Third glucose control visit)
OTHERBrown Rice
Unpolished brown rice containing 50 g of available carbohydrate was cooked using a rice cooker (Toyomi) at a ratio of rice to water of 1: 2
OTHER3 % polished rice
3% polished rice, containing 50 g of available carbohydrate was cooked using a rice cooker at a ratio of rice to water of 1: 2
OTHER6 % polished rice
6% polished rice, containing 50 g of available carbohydrate was cooked using a rice cooker at a ratio of rice to water of 1: 2
OTHER9 % polished rice
9 % polished rice, containing 50 g of available carbohydrate was cooked using a rice cooker at a ratio of rice to water of 1: 2
OTHER20 % Polished rice
White rice (20% polished rice), containing 50 g of available carbohydrate was cooked using a rice cooker at a ratio of rice to water of 1: 2.
Sponsors
Singapore Institute of Food and Biotechnology Innovation
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
NONE
Intervention model description
Randomized crossover design
Eligibility
Sex/Gender
MALE
Age
21 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Male * Chinese ethnicity * Age ≥21 and ≤ 60 years * Body mass index between 18.5 to 25 kg/m2 * Normal blood pressure =\<140/90 mmHg * Fasting blood glucose \<6.0 mmol/L * In general good health
Exclusion criteria
* Current smoker * Have any metabolic diseases (such as diabetes, hypertension etc) * Do not have known glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency) * Have medical conditions and/or taking medications known to affect glycaemia (glucocorticoids, thyroid hormones, thiazide diuretics) * Have intolerances or allergies to any foods * Currently partake in sports at the competitive and/or endurance levels * Intentionally restrict food intake
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Glucose | Up to 180 minutes | Whole capillary blood glucose will be measure using Hemocue analyser |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Insulin | Up to 180 minutes | Capillary plasma will be measure using Cobas analyser |
Countries
Singapore
Outcome results
None listed