Cardiovascular Risk Factor
Conditions
Brief summary
The main aim of this study is to examine the effect of olive oil consumption on several cardiovascular risk markers between Caucasians and Asian ethnicity. The primary assessments: endothelial function's biomarkers: cell and vascular adhesion molecules (ICAMs and VCAMs) and nitric oxide (NO). The secondary assessments: Lipid profile.
Interventions
DIETARY_SUPPLEMENTOlive oil
Participants will be randomly allocated to receive daily dose of 30ml of olive oil (OO) as intervention group or a matching control (butter 30g) for 2 weeks each (i.e. two weeks olive oil and two weeks butter), separated by a washout period of 2 weeks between treatments.
DIETARY_SUPPLEMENTButter
Participants will be randomly allocated to receive daily dose of 30ml of olive oil (OO) as intervention group or a matching control (butter 30g) for 2 weeks each (i.e. two weeks olive oil and two weeks butter), separated by a washout period of 2 weeks between treatments.
Sponsors
Northumbria University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
A randomized, double-blind, placebo-controlled crossover trial.
Eligibility
Sex/Gender
MALE
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
Male Orient Asians (including Chinese, Japanese, Korean, and Malaysia Chinese) and Caucasians Age 18-70 years Self-reported in good general health
Exclusion criteria
Female Age older than 70 years or younger than 18 years Diagnosed and/or are taking medications for hypertension (\>140/90mmHg) Diabetes High blood cholesterol Heart problems (e.g. arrhythmia, high-grade stenosis of the carotid artery or carotid sinus syndrome) Allergy to olive oil or olive oil products Lactose intolerance Taking omega-3 supplements in fish oil and vitamins supplements in the last six months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| changes in ambulatory blood pressure | Baseline and 2 weeks |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes in Intercellular Adhesion Molecule 1 | Baseline and 2 weeks | Plasma levels of Intercellular Adhesion Molecule 1 measured |
| Changes in plasma total cholesterol | Baseline and 2 weeks | Plasma total cholesterol vascular cell adhesion molecule 1 |
| Changes in vascular cell adhesion molecule 1 | Baseline and 2 weeks | Plasma levels of vascular cell adhesion molecule 1 measured |
| Changes in C-reactive protein | Baseline and 2 weeks | Plasma levels of CRP measured |
Countries
United Kingdom
Outcome results
None listed