Erectile Dysfunction Following Radical Prostatectomy
Conditions
Brief summary
This study evaluates the retinal and choriocapillary vascular features in patients under the effects of Tadalafil 20mg using optical coherence tomography angiography.
Detailed description
Tadalafil is a an inhibitor of the enzyme phosphodiesterase and it works by increasing blood flow to the penis thus promoting the erection. This drug represents an treatment for erectile dysfunction in patients after radical prostatectomy. The optical coherence tomography angiography represents a novel and non-invasive diagnostic technique that allows a detailed and quantitative analysis of retinal and choriocapillary vascular features. The study evaluates the changes in optical coherence tomography angiography parameters at baseline and after 1, 3, 6 months after the somministration of Tadalafil 20 mg orally.
Interventions
DRUGTadalafil 20 MG
To study retinal and choriocapillary features in patients undergoing Tadalafil 20 mg orally, on alternate days, at baseline and 1, 3, 6 months after radical prostatectomy
Sponsors
Federico II University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
MALE
Age
45 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* age older than 45 years * diagnosis of erectile dysfunction due to surgery of radical prostatectomy * treatment-naïve with Tadalafil for erectile dysfunction * absence of vitreoretinal and vascular retinal diseases * absence of diabetes
Exclusion criteria
* age younger than 45 years * diagnosis of erectile dysfunction due to other causes * previous treatments before Tadalafil for erectile dysfunction * presence of vitreoretinal and vascular retinal diseases * presence of diabetes.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The measurements of retinal and choriocapillary vessel density in patients undergoing Tadalafil after radical prostatectomy | Six months | Changes in retinal and choriocapilary vessel density in 40 patients undergoing Tadalafil 20 mg orally, on alternate days, at baseline and 1, 3, 6 months after radical prostatectomy, using optical coherence tomography angiography. The parameters analyzed by optical coherence tomography angiography were: retinal and choriocapillary vessel density |
Countries
Italy
Outcome results
None listed