Low Dose Euthyrox in Treatments of Paraquat Intoxication.

Low Dose Euthyrox in Treatments of Paraquat Intoxication: a Randomized, Controlled, Multicenter Trial in China.

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04132622

Acronym

LDETPI

Enrollment

Registered

2019-10-21

Start date

2020-01-01

Completion date

2023-12-31

Last updated

2019-10-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Paraquat Poisoning

Keywords

Euthyrox, Paraquat Intoxication

Brief summary

Paraquat is a common human toxicant and accounts for 20 deaths per million persons in the world. Paraquat usually cause multiple organ dysfunction syndrome, including liver, kidney, lung and heart dysfunction. Besides, pituitary insufficiency also occurs on those patients with paraquat poisoning, which leads to multiple endocrine gland dysfunction, involving adrenal gland, thyroid and sex gland. As a result, the investigators decide to initiate the clinical trial to find whether thyroid replacement therapy can furtherly reduce the mortality, and improve patients long-term prognosis.

Detailed description

Paraquat is a common human toxicant and accounts for 20 deaths per million persons in the world. Its accidental or deliberate ingestion is associated with a high mortality rate ranging from 40% to 70%. Paraquat usually cause multiple organ dysfunction syndrome, including liver, kidney, lung and heart dysfunction. Besides, pituitary insufficiency also occurs on those patients with paraquat poisoning, which leads to multiple endocrine gland dysfunction, involving adrenal gland, thyroid and sex gland. Nowadays, steroids, as a hormone replacement therapy, is one of most important drugs for paraquat poisoning, and it has decreased patients' mortality greatly since using it. However, the clinicians have not paid enough attention to thyroid replacement therapy, as thyroid dysfunction is also the key pathophysiological course when paraquat poisoning occurs. As a result, the investigators decide to initiate the clinical trial to find whether thyroid replacement therapy can furtherly reduce the mortality, and improve patients long-term prognosis.

Interventions

DRUGLevothyroxine Sodium

Levothyroxine Sodium Tablets (50 ug, calculated by Levothyroxine Sodium ), produced by Merck KGaA, Darmstadt.

DRUGTraditional therapy

including steroids, vitamin C, hemodialysis and blood perfusion.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* all the patients who are diagnosed by paraquat poisoning

Exclusion criteria

* patients who can not cooperate with the trial; patients who would not like to join in the trial.

Design outcomes

Primary

Measure	Time frame	Description
Rate of death weekly	a week	Rate of death in a week.
Rate of death monthly	a month	Rate of death in a month.
Rate of death yearly	a year	Rate of death in a year.
Survival rate yearly	a year	Survival rate in a year.

Secondary

Measure	Time frame	Description
Number of Participants with Kidney dysfunction	a week, a month, a year	Number of Participants with Kidney dysfunction with paraquat poisoning

Contacts

Primary ContactYuemei Chen, doctor

324347@zju.edu.cn+86 18758120192

Backup ContactXiu Yang, master

+86 13732221703

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026