Levothyroxine Sodium

DRUG13 trials

Sponsors

Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC), ZonMW, Asociacion Instituto De Investigacion Sanitaria Biobizkaia, Region Midtjylland, Universidad Autonoma de Nuevo Leon, University of California, Irvine

Conditions

Chronic Kidney DiseaseCongenital HypothyroidismDiabetes Mellitus, Type 2HemodialysisHypothyroidismHypothyroidism Triiodothyronine Quality of Life Persistant complaintsIncident Kidney DysfunctionKidney Diseases, Chronic

Phase 2

Subclinical Hypothyroidism and Mind in the Elderly

CompletedNCT00921050

Universidad Autonoma de Nuevo LeonSubclinical Hypothyroidism

Start: 2009-06-30End: 2012-03-31Updated: 2012-06-28

Levothyroxine for Non-Alcoholic Fatty Liver Disease (NAFLD)

TerminatedNCT03281083

Duke-NUS Graduate Medical SchoolDiabetes Mellitus, Type 2, Non-Alcoholic Fatty Liver Disease

Start: 2014-03-28End: 2016-07-28Updated: 2017-09-14

Study of XP-8121 For the Treatment of Adult Subjects With Hypothyroidism

CompletedNCT05823012

Xeris PharmaceuticalsHypothyroidism

Start: 2023-05-15End: 2024-02-22Updated: 2025-07-03

Phase 3

A national randomized placebo-controlled double-blind multicenter trial of LT4/LT3 combination therapy in patients with autoimmune hypothyroidism: the T3-4-Hypo trial

Not yet recruitingCTIS2024-513883-24-00

Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC), ZonMWHypothyroidism Triiodothyronine Quality of Life Persistant complaints

Target: 600Updated: 2025-07-11

Phase 4

Low Dose Euthyrox in Treatments of Paraquat Intoxication.

Second Affiliated Hospital, School of Medicine, Zhejiang UniversityParaquat Poisoning

Start: 2020-01-01End: 2023-12-31Target: 80Updated: 2019-10-22

Comparison of Levothyroxine Formulation in Hypothyroid Patients With Enteral Feeding

TerminatedNCT04878614

University of California, Los AngelesHypothyroidism

Start: 2021-05-05End: 2022-02-16Updated: 2023-04-10

Use of Tirosint®-SOL or Tablet Formulations of Levothyroxine in Pediatric Patients With Congenital Hypothyroidism (CH)

TerminatedNCT05228184

IBSA Institut Biochimique SACongenital Hypothyroidism

Start: 2022-01-21End: 2025-03-27Updated: 2025-10-23

Dosing of LT4 in Older Individuals

RecruitingNCT06073665

University of PennsylvaniaHypothyroidism

Start: 2024-01-31End: 2028-04-01Target: 228Updated: 2026-02-19

Impact of levothyroxine on erectile function measured by the IIEF-15, EHS, PGIC and EDITS questionnaires in patients with hypothyroidism. Prospective, randomized controlled clinical trial with sildenafil 100

CompletedCTIS2024-514789-38-00

Asociacion Instituto De Investigacion Sanitaria Biobizkaiaerectile function, hypothyroidism subclinic

End: 2025-12-01Target: 90Updated: 2024-12-23

Impact of Early Thyroid Hormone Replacement on Kidney Function and Health-Related Quality of Life in Patients at Risk of Postoperative Hypothyroidism after Hemithyroidectomy: A Randomised Controlled Trial

Not yet recruitingCTIS2025-524175-23-00

Region MidtjyllandChronic Kidney Disease, Hypothyroidism, Incident Kidney Dysfunction

Target: 56Updated: 2026-03-03

Unknown Phase

A Pilot Feasibility Trial of Thyroid Hormone Replacement in Dialysis Patients

University of California, IrvineKidney Diseases, Chronic, Thyroid Disease

Start: 2017-07-01End: 2021-07-31Target: 96Updated: 2021-06-14

Quality of Life After Interventional Thyroid Treatment

CompletedNCT03880578

Klinikum LüdenscheidQuality of Life, Thyroid; Deficiency

Start: 2019-04-01End: 2022-03-15Updated: 2024-10-29

A Randomized Controlled Trial of Thyroid Hormone Supplementation in Hemodialysis Patients

RecruitingNCT03977207

University of California, IrvineHemodialysis, Hypothyroidism, Thyroid; Functional Disturbance

Start: 2020-07-20End: 2025-11-30Target: 336Updated: 2025-09-08