Type2 Diabetes Mellitus
Conditions
Keywords
Glucokinase Activator, Glucose control
Brief summary
At present, there are few studies on the clinical remission rate of diabetes after one year discontinuation of oral hypoglycemic drugs after intensive treatment. HMS5552 is a kind of GKA hypoglycemic drug. This study intends to observe the clinical remission rate of diabetes mellitus, beta cell function and blood sugar fluctuation of patients with type 2 diabetes mellitus who have been treated with HMS5552 for 52W or 28W and whose glucose control is up to the standard.
Interventions
DRUGHMS5552
To observe the progress of diabetes mellitus after 52 or 28 weeks of HMS5552 treatment for type 2 diabetes mellitus
Sponsors
Majianhua
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Complete HMS5552 treatment and safety visit; * HbA1c \< 8.0% was detected in our laboratory; * Researchers judged the stability of glucose control based on the data of subjects'visits during HMS5552 treatment and the indicators of our hospital; * Subjects are able and willing to monitor peripheral blood sugar and regularity of diet and exercise; * Willing to sign written informed consent and abide by the research program.
Exclusion criteria
* There was a state of illness in the subjects who could not complete the follow-up during the observation period. * The researchers judged that subjects'compliance with HMS5552 was affected during treatment.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| HbA1c | 4 weeks | Changes of HbA1c |
| Fasting glucose | 4 weeks | Changes of fasting glucose |
| Postprandial glucose | 4 weeks | Changes of postprandial glucose |
| C peptide | 4-8 weeks | Changes of C peptide |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| IL-6 | 52 weeks | Changes of IL-6 |
| 8-iso PGF2α | 52 weeks | Changes of 8-iso PGF2α |
| TNF-α | 52 weeks | Changes of TNF-α |
Countries
China
Outcome results
None listed