Dietary Supplement: Ketone Supplement, Dietary Supplement: Placebo
Conditions
Brief summary
The ketone body beta-hydroxybutyrate is produced during prolonged fasting or when endogenous carbohydrate stores are depleted and can be used as an alternative fuel source. Exogenous beta-hydroxybutyrate, in the form of a ketone monoester, is proposed to have glucose-lowering potential but this has not been adequately studied. The purpose of this study is to determine whether supplementing with an acute dose of ketone monoester can improve the glycemic response to a high carbohydrate mixed meal in young healthy individuals.
Interventions
DIETARY_SUPPLEMENTKetone monoester
Acute ingestion of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate prior a 2-hour high carbohydrate mixed meal tolerance test.
DIETARY_SUPPLEMENTPlacebo
Acute ingestion of a taste-matched placebo prior a 2-hour high carbohydrate mixed meal tolerance test.
Sponsors
University of British Columbia
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Outcomes Assessor)
Masking description
Placebo masked with flavouring and participants consume in opaque containers
Intervention model description
Crossover assignment
Eligibility
Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Young healthy individuals * Not taking any medications affecting glucose metabolism
Exclusion criteria
* Competitive endurance athlete (i.e., train specifically for cycling, triathlon or distance running and compete at a high level) * Diagnosed with the chronic medical condition that may impact consumption of carbohydrates or supplements (e.g., diabetes, heart disease) * Are currently using medications that may interfere with insulin sensitivity * Adhere to a strict high-fat low-carbohydrate or ketogenic diet (within the last 3 months) * Are currently using ketone supplements * Unable to travel to and from the university in order to make your testing appointments. * Unable to follow the controlled diet instructions required for the study. * If pregnant or are planning to become pregnant during the study (if female)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Glucose area under the curve | 2-hour | Area under the curve for glucose during high carbohydrate mixed meal tolerance test |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Free fatty acids area under the curve | 2-hour | Non-esterified fatty acids area under the curve during high carbohydrate mixed meal tolerance test |
| Glucose incremental area under the curve | 2-hour | Incremental area under the curve (above baseline) for glucose during high carbohydrate mixed meal tolerance test |
| Insulin area under the curve | 2-hour | Insulin area under the curve during high carbohydrate mixed meal tolerance test |
| 2-hr glucose level | 2-hour | Plasma glucose assessed 2-hr after high carbohydrate mixed meal tolerance test |
| Beta-hydroxybutyrate level | 2-hour | Blood beta-hydroxybutyrate concentration assessed by handheld monitor |
| Insulin incremental area under the curve | 2-hour | Incremental area under the curve (above baseline) for insulin during high carbohydrate mixed meal tolerance test |
Countries
Canada
Outcome results
None listed