Diabetes
Conditions
Brief summary
The study specifically aims to determine glycemic and insulinemic response of added low GI ingredients, beta-glucan, resistant starch and isomaltulose to foods.
Detailed description
There will be a total of 9 test sessions and each session will last up to 3 hours. At each test session, the following procedures will be performed: two finger-prick blood samples, five minutes apart to measure baseline blood glucose and insulin concentrations. Subject will be served the test food and to consume within15 minutes. Following the test meal, blood samples will be collected at the following time points: 15, 30, 45, 60, 90, 120, 150 and 180min for glucose measurements and insulin measurements will be collected at 30, 60, 90, 120, 150 and 180min.
Interventions
OTHERGlucose Reference 1
Glucose contains 50g of available carbohydrates
OTHERGlucose Reference 2
Glucose contains 50g of available carbohydrates
OTHERGlucose Reference 3
Glucose contains 50g of available carbohydrates
OTHERWheat Yellow Noodle
Wheat Yellow Noodle will contain 50g of available carbohydrate
OTHERBeta-glucan yellow Noodle
Beta-glucan yellow noodle will contain 50g of available carbohydrate
OTHERRice Roll
Rice Roll will contain 50g of available carbohydrate
OTHERRice Roll with resistant starch
Rice Roll fortified with resistant starch will contain 50g of available carbohydrate
OTHERSucrose Jelly
Jelly and bread will contain 50g of available carbohydrate. The jelly will contain 25g of sucrose
OTHERIsomaltulose Jelly
Jelly and bread will contain 50g of available carbohydrate. The jelly will contain 25g of Isomaltulose
Sponsors
Health Promotion Board, Singapore
Singapore Institute of Food and Biotechnology Innovation
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
21 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy Males * Chinese ethnicity * Age ≥21 and ≤ 40 years * Body mass index between 18.5 to 25 kg/m2 * Normal blood pressure ≤140/90 mmHg * Fasting blood glucose \<6.0 mmol/L * In general good health
Exclusion criteria
* Current smoker * Have metabolic diseases (such as diabetes, hypertension etc) * Have glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency) * Have medical conditions and/or taking medications known to affect glycaemia (glucocorticoids, thyroid hormones, thiazide diuretics) * Have an ongoing infection or currently undergoing treatment at the time of screening * Have known Chronic infection or known to suffer from or have previously suffered from or is a carrier of Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), Human Immunodeficiency Virus (HIV) * Have active Tuberculosis (TB) or currently receiving treatment for TB * Intolerances or allergies to any foods * Partake in sports at the competitive and/or endurance levels * Intentionally restrict food intake
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Glucose | up to 180 minutes | Blood glucose will be collected using finger prick method and analysed using Hemocue analyser |
| Insulin | up to 180 minutes | Blood glucose will be collected using finger prick method and analysed using Cobas analyser |
Countries
Singapore
Outcome results
None listed