Anti-VEGF, Branch Retinal Vein Occlusion, Vitrectomy
Conditions
Brief summary
To evaluate the efficacy and safety of Anti-VEGF instead of intraoperative fan-shaped photocoagulation in BRVO combined with vitreous hemorrhage.
Interventions
PROCEDUREanti-VEGF
vitreoretinal surgery combined with intraoperative anti-VEGF
PROCEDUREfan-shaped photocoagulation
vitreoretinal surgery combined with intraoperative fan-shaped photocoagulation
Sponsors
Wenzhou Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. Age ≥ 18 years old; 2. BRVO is diagnosed 3. Vitreous hemorrhage 4. Vitreous hemorrhage combined with mild retinal fibrovascular proliferation (early fibrous vascular membrane, thin fibrous vascular membrane, loose retinal adhesion and intact local retinal structure)
Exclusion criteria
1. BRVO combined with severe retinal fibrovascular proliferation (long-term fibrovascular membrane, thick fibrous vascular membrane and tightly attached to the retina, deformation of local retinal, retinal tear or suspension of retinal vein ) 2. BRVO combined with retinal detachment 3. Retinal veins are completely whitened 4. iris neovascularization or neovascular glaucoma 5. Combined glaucoma 6. combined with other retinopathy 7. Received anti-VEGF treatment within 3 months before surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mean change from baseline in best-corrected visual acuity (BCVA) | 3 years | Assessed using the ETDRS protocol |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Mean change from baseline in visual field | 3 years | Assessed on Humphery(30-2 and 60-4) |
| chang from baseline in structure of retina | 3 years | Assessed on Optical Coherence Tomography(OCT) |
| chang from baseline in retinal neovascularization | 3 years | Assessed on Fundus Fluorescein Angiography(FFA) |
Contacts
Primary ContactYong Wei, M.D
Backup ContactWei Lin, M.D
Outcome results
None listed