Anti-VEGF, Proliferative Diabetic Retinopathy, PRP, Vitrectomy
Conditions
Brief summary
To evaluate the efficacy and safety of vitreoretinal surgery combined with anti-VEGF therapy in the replacement of intraoperative PRP in PDR therapy.
Interventions
PROCEDUREanti-VEGF
vitreoretinal surgery combined with intraoperative anti-VEGF
PROCEDUREPRP
vitreoretinal surgery combined with intraoperative PRP
Sponsors
Wenzhou Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. Age≥18 years old; 2. type 1 or type 2 diabetes. 3. proliferative diabetic retinopathy with vitreous hemorrhage, and conservative treatment of vitreous hemorrhage without obvious absorption for 1 month requires vitreoretinal surgery; 4. The postoperative refractive medium is clear and the pupil is large enough to obtain sufficient clear fundus
Exclusion criteria
1. Previously received panretinal photocoagulation or unfinished panretinal photocoagulation; 2. Pulling retinal detachment involving the macula or the presence of extensive fiber proliferation requires silicone oil filling; 3. anterior chamber neovascularization or neovascular glaucoma; 4. other vascular diseases such as retinal vein occlusion, arterial occlusion, etc; 5. received intraocular anti-VEGF therapy or triamcinolone acetonide treatment which are still in the treatment period.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mean change from baseline in best-corrected visual acuity (BCVA) | 3 years | Assessed using the ETDRS protocol |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Mean change from baseline in visual field | 3 years | Assessed on Humphery(30-2 and 60-4) |
| chang from baseline in sructure of retina | 3 years | Assessed on Optical Coherence Tomography(OCT) |
| chang from baseline in retinal neovascularization | 3 years | Assessed on Fundus Fluorescein Angiography(FFA) |
Contacts
Primary ContactYong Wei, M.D
Backup ContactWei lin, M.D
Outcome results
None listed