Depression
Conditions
Brief summary
Electrical vagus nerve stimulation (VNS) was approved by FDA for treatment of chronic recurrent depression in 2005. Recently, non-invasive, transcutaneous auricular vagus nerve stimulation （taVNS） has already been used for depression treatment. However, the neural mechanism remains unclear, and the relationship between stimulation parameters and neural response were also unknown. The present study aims to investigate the specific brain activation in depression patients after taVNS，compared with healthy controls.
Interventions
All subjects receive electrical stimulation at earlobe.
All subjects receive electrical VNS stimulation at cymba conchae.
Sponsors
Xidian University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
15 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Meets ICD-10 diagnosis standard; * without taking anti-depressive medication or other psychiatric medications 2 weeks before the experiment; * Patient has exhibited symptoms for at least 2 months, but no longer than 2 years.
Exclusion criteria
* With current addiction to drugs; * With other severe organic diseases, such as severe heart disease, kidney failure etc; * disagree with the consent form. * Cannot receive MRI scan.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| actual neural activation in brain | 2 hours | By using fMRI technology, the BOLD signal of brain is analyzed. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Heart rate variability | 2 hours | Frequency domain methods is used to analyze the bands of frequency and then count the number of NN intervals that match each band. The bands are typically high frequency (HF) from 0.15 to 0.4 Hz, low frequency (LF) from 0.04 to 0.15 Hz, and the very low frequency (VLF) from 0.0033 to 0.04 Hz. |
Contacts
Primary Contactxuejuan Yang
Outcome results
None listed