Effects of Grape Juice With Breakfast on Glycemia and Cognitive Function in Healthy Adults

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03409497

Enrollment

Registered

2018-01-24

Start date

2019-05-17

Completion date

2020-06-30

Last updated

2020-11-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Appetitive Behavior, Glycemic Response

Brief summary

Assess the impact of 100% grape juice with a meal on postprandial glycemic response and subsequent appetite, food intake and cognitive function.

Detailed description

Investigators earlier studies and published literature suggest that the phenolic content and strong flavor intensity of 100% Concord grape juice hold potential beneficial effects on blood sugar levels. Investigators aim to better understand the consumption of 100% grape juice with a meal modifies appetite and glycemia acutely and over the day using a 24 hour glucose monitor.

Interventions

OTHERConcord Grape Juice

Concord Grape Juice

OTHERLow flavonoid low essence beverage

Low flavonoid low essence beverage

OTHERLow flavonoid beverage

Low flavonoid beverage

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

25 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* BMI between 25.0-34.9 kg/m2 * Willingness to eat all test foods * Low consumer of tea and coffee, willingness to refrain from both during the 48 hours prior to test days and on the test day * Fasting blood glucose below 6.1mmol/l via capillary finger-stick blood sample using a SureStep glucometer (Lifescan, Milpitas, CA)

Exclusion criteria

* Taking medications known to affect glycemia, lipid metabolism or appetite * Body weight fluctuation of \>5kg in the past 3 months * Taking vitamin or other supplements * Smokers * Acute or Chronic disease

Design outcomes

Primary

Measure	Time frame	Description
change in blood glucose over 24 hours	24 hours	samples taken every 5 minutes for 24 hours by a continuous glucose monitor

Secondary

Measure	Time frame	Description
Appetite	24 hours	Questionnaire on hunger, fullness, desire to eat, prospective consumption, thirst taken hourly on same day as grape juice intervention

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 20, 2026