Appetitive Behavior, Glycemic Response
Conditions
Brief summary
Assess the impact of 100% grape juice on postprandial glycemic response and subsequent appetite, food intake and cognitive function.
Detailed description
Investigators earlier clinical work and published literature suggest that the phenolic content and strong flavor intensity of 100% Concord grape juice hold potential beneficial effects on appetite and glycemia. Investigators aim to better understand the use of 100% grape juice modifies appetite and glycemia acutely and over the day using a 24 hour glucose monitor.
Interventions
OTHERConcord Grape Juice
Concord Grape Juice
OTHERLow flavoniod low essence beverage
Low flavoniod low essence beverage
Low flavonoid beverage
Sponsors
Welch's Food Corporation
Purdue University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
25 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* BMI between 25.0-34.9 kg/m2 * Willingness to eat all test foods * Low consumer of tea and coffee, willingness to refrain from both during the 48 hours prior to test days and on the test day. * Fasting blood glucose below 6.1mmol/l via capillary finger-stick blood sample using a SureStep glucometer (Lifescan, Milpitas, CA)
Exclusion criteria
* Taking medications known to affect glycemia, lipid metabolism or appetite * Body weight fluctuation of \>5kg in the past 3 months * Taking vitamin or other supplements * Smokers * Acute or Chronic disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in blood glucose over 24 hours | 24 hours | samples taken every 5 minutes for 24 hours by a continuous glucose monitor |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Appetite | 24 hours | Questionnaire on hunger, fullness, desire to eat, prospective consumption, thirst taken hourly on same day as grape juice intervention |
Countries
United States
Outcome results
None listed