Aneurysm Cerebral
Conditions
Keywords
dexmedetomidine, general anesthesia, cerebral aneurysm
Brief summary
Dexmedetomidine induces analgesic and sedative effects and is reported to decrease agitation during emergence after general anesthesia in various surgeries. For patients undergoing cranial aneurysm surgeries, a calm anesthesia and emergence is important. In this study, the investigatorstend to observe the effect of dexmedetomidine on maintenance and recovery of patients undergoing cranial aneurysm surgeries.
Interventions
drug is intravenously infused to patients
DRUGnasal dexmedetomidine
drug is nasally given to patients
saline is given to patients intravenously
DRUGnasal saline
normal saline is given to patients nasally
Sponsors
Zhihong LU
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* patients undergoing cerebral aneurysm embolism under general anesthesia
Exclusion criteria
* patients with bradycardia or atrioventricular heart block * patients with ASA(American Society of Anesthesiologists) status over 3 * patients with body mass index(BMI)≥30kg/m2 * patients with difficulty in communication * patients with ruptured aneurysm * patients suspected or proved to be pregnant
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| incidence of coughing | from end of infusing anesthetics to 2 minutes after extubation, averagely 30 minutes |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| score of coughing | from end of infusing anesthetics to 2 minutes after extubation, averagely 30 minutes | 0=no coughing;1=intermittent coughing;2=continuous coughing |
| time to response to verbal command | from end of infusing anesthetics to response to verbal command,averagely 20 minutes | — |
| time to extubation | from end of infusing anesthetics to extubation,averagely 28 minutes | — |
| Ricker's agitation-sedation score | from end of infusing anesthetics to 2 minutes after extubation, averagely 30 minutes | — |
| blood glucose before and after aneurysm embolism | immediately before inserting coil and after finishing inserting coil,an average of 1 hour | — |
| blood lactate before and after aneurysm embolism | immediately before inserting coil and after finishing inserting coil,,an average of 1 hour | — |
| Mini-mental state examination score | 24 hours after surgery | — |
| blood pressure before and after extubation | from end of infusing anesthetics to 2 minutes after extubation, averagely 30 minutes | — |
Countries
China
Outcome results
None listed