H7N9 Vaccination With and Without AS03 and Unadjuvanted H3N2v Vaccination: Standard and Systems Biology Analyses

A Phase II Study to Evaluate and Compare the Immunogenicity of Monovalent Inactivated Influenza A/H7N9 Virus Vaccine Administered With and Without AS03 Adjuvant and Monovalent Inactivated Influenza A/H3N2v Virus Vaccine Administered Without Adjuvant in Healthy Adults Through Standard and Systems Biology Analyses

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02921997

Enrollment

Registered

2016-10-03

Start date

2016-11-07

Completion date

2018-02-14

Last updated

2024-10-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Avian Influenza, H1N1 Influenza, Influenza

Keywords

A/H5N1, A/H7N9, ASO3 Adjuvant, influenza, monovalent, pH1N1, vaccines

Brief summary

Detailed description

This is a single center, randomized, partially-blinded, Phase II, small, targeted, prospective study in approximately 30 healthy male and non-pregnant female subjects aged 18 to 49 years old, inclusive, designed to evaluate and compare the immunogenicity between an intramuscular monovalent inactivated influenza A/H7N9 virus vaccine manufactured by Sanofi Pasteur given with and without AS03 adjuvant manufactured by GlaxoSmithKline, and an intramuscular unadjuvanted monovalent inactivated influenza A/H3N2v virus vaccine manufactured by Sanofi Pasteur. The primary objectives are (1) assessing the serum anti-HA hemagglutination-inhibition (HAI) response to influenza A/H7N9 antigen (with and without adjuvant) at Day 57 (approximately one month after the second study vaccination with A/H7N9 vaccine with or without AS03) and influenza A/H3N2v antigen at Day 29 (approximately one month after the study vaccination with A/H3N2v), and (2) identifying differentially expressed genes in human immune cells on Days 2, 4, and 29 (following the first study vaccination with A/H7N9 vaccine with or without AS03) and on Days 30, 32, and 36 (following the second study vaccination with A/H7N9 vaccine with or without AS03), compared to baseline assessments performed prior to each study vaccination (Days -7, 1, and 29). The secondary objectives are: (1) compare plasma cytokine and chemokine profiles at specific time points and between treatment arms at post vaccination points, (2) assess the neutralizing antibody responses to influenza A/H7N9 antigen (with and without adjuvant) at Day 57 (approximately one month after the second study vaccination with A/H7N9 vaccine with or without AS03) and influenza A/H3N2v antigen at Day 29 (approximately one month after the study vaccination with A/H3N2v vaccine), and (3) identify differentially expressed genes in human immune cells on Days 2, 4, and 8 following one intramuscular dose of influenza A/H3N2v vaccine compared to baseline assessments performed prior to study vaccination (Day -7 and Day 1).

Interventions

DRUGAS03

AS03 oil-in-water emulsion adjuvant.

BIOLOGICALInfluenza Virus Vaccine, Monovalent A/H3N2v A/Minnesota/11/2010 NYMC X-203

Inactivated monovalent subvirion H3N2v vaccine containing hemagglutinin (HA) of A/Minnesota/11/2010 NYMC X-203 virus.

BIOLOGICALMonovalent influenza A/H7N9 virus vaccine

Monovalent influenza A/H7N9 virus vaccine.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 49 Years

Healthy volunteers

Yes

Inclusion criteria

1. Provide written informed consent prior to initiation of any study procedures. 2. Are able to understand and comply with planned study procedures and be available for all study visits. 3. Are males or non-pregnant females, 18 to 49 years old, inclusive. 4. Are in good health\*. \*As determined by medical history and targeted physical examination, if indicated based on medical history, to evaluate acute or currently ongoing chronic medical diagnoses or conditions, defined as those that have been present for at least 90 days, that would affect the assessment of the safety of subjects or the immunogenicity of study vaccinations. Chronic medical diagnoses or conditions should be stable for the last 60 days. This includes no change in chronic prescription medication, dose, or frequency as a result of deterioration of the chronic medical diagnosis or condition in the 60 days prior to enrollment. Any prescription change that is due to change of health care provider, insurance company, etc., or that is done for financial reasons, as long as in the same class of medication, will not be considered a deviation of this inclusion criterion. Any change in prescription medication due to improvement of a disease outcome, as determined by the site principal investigator or appropriate sub-investigator, will not be considered a deviation of this inclusion criterion. Subjects may be on chronic or as needed (prn) medications if, in the opinion of the site principal investigator or appropriate sub-investigator, they pose no additional risk to subject safety or assessment of reactogenicity and immunogenicity and do not indicate a worsening of medical diagnosis or condition. Similarly, medication changes subsequent to enrollment and study vaccination are acceptable provided there was no deterioration in the subject's chronic medical condition that necessitated a medication change, and there is no additional risk to the subject or interference with the evaluation of responses to study vaccination. Note: Topical, nasal, and inhaled medications (with the exception of inhaled corticosteroids as outlined in the Subject

Exclusion criteria

), herbals, vitamins, and supplements are permitted. 5. Oral temperature is less than 100.4 degrees F. 6. Pulse is 50 to 115 bpm, inclusive. 7. Systolic blood pressure is 85 to 150 mm Hg, inclusive. 8. Diastolic blood pressure is 55 to 95 mm Hg, inclusive. 9. Erythrocyte sedimentation rate (ESR) is less than 30 mm per hour. 10. Women of childbearing potential\* must use an acceptable contraception method\*\* from 30 days before first study vaccination until 60 days after last study vaccination. \*Not sterilized via tubal ligation, bilateral oophorectomy, hysterectomy or successful Essure (R) placement (permanent, non-surgical, non-hormonal sterilization) with documented radiological confirmation test at least 90 days after the procedure, and still menstruating or \<1 year of the last menses if menopausal. \*\*Includes, but is not limited to, non-male sexual relationships abstinence from sexual intercourse with a male partner, monogamous relationship with vasectomized partner who has been vasectomized for 180 days or more prior to the subject receiving the first study vaccination, barrier methods such as condoms or diaphragms with spermicide or foam, effective intrauterine devices, NuvaRing (R), and licensed hormonal methods such as implants, injectables or oral contraceptives (the pill). 11. Women of childbearing potential must have a negative urine or serum pregnancy test within 24 hours prior to study vaccination.

Design outcomes

Primary

Measure	Time frame	Description
Percentage of Participants Achieving Seroconversion Based on HAI Titer (A/H7N9 Vaccine, With and Without Adjuvant)	Day 29 Post-Vaccination 2 (Day 57)	Seroconversion is defined as either a pre-vaccination HAI titer \<1:10 and a post-vaccination HAI titer =\>1:40 or a pre-vaccination HAI titer =\>1:10 and a minimum four-fold rise in post-vaccination HAI antibody titer. Venous blood samples for serum were used for this assay. HAI based on the H7N9 strain A/Shanghai/02/2013xPR8 were assessed.
Percentage of Participants Achieving Seroconversion Based on HAI Titer (A/H3N2v Vaccine)	Day 29 Post-Vaccination 1 (Day 29)	Seroconversion is defined as either a pre-vaccination HAI titer \<1:10 and a post-vaccination HAI titer =\>1:40 or a pre-vaccination HAI titer =\>1:10 and a minimum four-fold rise in post-vaccination HAI antibody titer. Venous blood samples for serum were used for this assay. HAI based on the H3N2 strain A/Minnesota/11/2010 were assessed.
Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	Days 2, 4, and 29 Post-Vaccination 1 (Day 2, 4, and 29, respectively); Days 2, 4, and 8 Post-Vaccination 2 (Day 30, 32, and 36, respectively)	RNA expression levels (read counts) for each gene were determined by RNA-Sequencing of RNA extracted from six separated cell types: monocytes , dendritic cells, neutrophils, NK cells, B cells, and T cells. Post-vaccination gene expression levels were compared to pre-vaccination gene expression levels (combined summed read counts for Day -7 and Day 1 samples for post-vaccination 1 timepoints and Day 29 read counts for post-vaccination 2 timepoints) using a negative binomial model to identify differentially expressed (DE) genes (FDR-adjusted p-value \< 0.05 and mean fold change =\> 1.5 in either direction).

Secondary

Measure	Time frame	Description
Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	Day 1 Pre-Vaccination 1; Days 2, 4, 8, and 29 Post-Vaccination 1 (Day 2, 4, 8, and 29, respectively); Days 2, 4, and 8 Post-Vaccination 2 (Day 30, 32, and 36, respectively)	Venous blood samples for plasma were used for this assay. A Luminex assay was used to measure concentrations in ng/L. Concentrations for 4 of the total 24 cytokines and chemokines were measured: Macrophage Inflammatory Protein-1 Alpha (MIP1a), Macrophage Inflammatory Protein-1 Beta (MIP1b), Macrophage Inflammatory Protein-3 Alpha (MIP3a), and Tumor Necrosis Factor Alpha (TNF-a). If no cytokine or chemokine measurements were collected, number of participants is reported as 0.
Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	Days 2, 4, 8, and 29 Post-Vaccination 1 (Day 2, 4, 8, and 29, respectively); Days 2, 4, and 8 Post-Vaccination 2 (Day 30, 32, and 36, respectively)	Venous blood samples for plasma were used for this assay. A Luminex assay was used to measure concentrations in ng/L. Concentrations for 7 of the total 24 cytokines and chemokines were measured: Fractalkine, GM-CSF, IP-10, IFNa, IFNb, IFNy, and ITAC. If no cytokine or chemokine measurements were collected, number of participants is reported as 0.
Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	Days 2, 4, 8, and 29 Post-Vaccination 1 (Day 2, 4, 8, and 29, respectively); Days 2, 4, and 8 Post-Vaccination 2 (Day 30, 32, and 36, respectively)	Venous blood samples for plasma were used for this assay. A Luminex assay was used to measure concentrations in ng/L. Concentrations for 17 of the total 24 cytokines and chemokines were measured: IL-1b, IL-10, IL-13, IL-2, IL-21, IL-23, IL-4, IL-5, IL-6, IL-7, IL-8, IL-12p70, IL-17A, MIP1a, MIP1b, MIP3a, and TNF-a. If no cytokine or chemokine measurements were collected, number of participants is reported as 0.
Percentage of Participants Achieving Seroconversion Based on Neut Titer (A/H7N9 Vaccine, With and Without Adjuvant)	Day 29 Post-Vaccination 2 (Day 57)	Seroconversion is defined as either a pre-vaccination Neut titer \<1:10 and a post-vaccination Neut titer =\>1:40 or a pre-vaccination Neut titer =\>1:10 and a minimum four-fold rise in post-vaccination Neut titer. Venous blood samples for serum were used for this assay. Neut based on the H7N9 strain A/Shanghai/02/2013xPR8 were assessed.
Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H3N2v Vaccine)	Days 2, 4, and 8 Post-Vaccination 1 (Day 2, 4, and 8, respectively)	RNA expression levels (read counts) for each gene were determined by RNA-Sequencing of RNA extracted from six separated cell types: monocytes, dendritic cells, neutrophils, NK cells, B cells, and T cells. Post-vaccination gene expression levels were compared to pre-vaccination gene expression levels (combined summed read counts for Day -7 and Day 1 samples for post-vaccination 1 timepoints) using a negative binomial model to identify differentially expressed (DE) genes (FDR-adjusted p-value \< 0.05 and mean fold change =\> 1.5 in either direction).
Geometric Mean Titers of Serum HAI Antibody (A/H7N9 Vaccine, With and Without Adjuvant)	Day 1 Pre-Vaccination 1, Day 29 Post-Vaccination 1 (Day 29), and Day 29 Post-Vaccination 2 (Day 57)	Venous blood samples for serum were used for this assay. HAI based on the H7N9 strain A/Shanghai/02/2013xPR8 were assessed.
Geometric Mean Titers of Serum HAI Antibody (A/H3N2v Vaccine)	Day 1 Pre-Vaccination 1 (Day 1), Day 29 Post-Vaccination 1 (Day 29)	Venous blood samples for serum were used for this assay. HAI based on the H3N2 strain A/Minnesota/11/2010 were assessed.
Geometric Mean Titers of Serum Neut Antibody (A/H7N9 Vaccine, With and Without Adjuvant)	Day 1 Pre-Vaccination 1 (Day 1), Day 29 Post-Vaccination 1 (Day 29), and Day 29 Post-Vaccination 2 (Day 57)	Venous blood samples for serum were used for this assay. Neut based on the H7N9 strain A/Shanghai/02/2013xPR8 were assessed.
Geometric Mean Titers of Serum Neut Antibody (A/H3N2v Vaccine)	Day 1 Pre-Vaccination 1 (Day 1), Day 29 Post-Vaccination 1 (Day 29)	Venous blood samples for serum were used for this assay. Neut based on the H3N2 strain A/Minnesota/11/2010 were assessed.
Percentage of Participants Achieving Seroconversion Based on Neut Titer (A/H3N2v Vaccine)	Day 29 Post-Vaccination 1 (Day 29)	Seroconversion is defined as either a pre-vaccination Neut titer \<1:10 and a post-vaccination Neut titer =\>1:40 or a pre-vaccination Neut titer =\>1:10 and a minimum four-fold rise in post-vaccination Neut titer. Venous blood samples for serum were used for this assay. Neut based on the H3N2 strain A/Minnesota/11/2010 were assessed.
Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	Day 1 Pre-Vaccination 1; Days 2, 4, 8, and 29 Post-Vaccination 1 (Day 2, 4, 8, and 29, respectively); Days 2, 4, and 8 Post-Vaccination 2 (Day 30, 32, and 36, respectively)	Venous blood samples for plasma were used for this assay. A Luminex assay was used to measure concentrations in ng/L. Concentrations for 11 of the total 24 cytokines and chemokines were measured: Fractalkine, Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF), Interferon-Gamma-Induced Protein-10(IP-10), Interferon-Alpha (IFNa), Interferon-Beta (IFNb), Interferon-Gamma (IFNy), Interferon-inducible T Cell Alpha Chemoattractant (ITAC), Interleukin 1 Beta (IL-1b), Interleukin 10 (IL-10), Interleukin 13 (IL-13), and Interleukin 2 (IL-2). If no cytokine or chemokine measurements were collected, number of participants is reported as 0.
Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	Day 1 Pre-Vaccination 1; Days 2, 4, 8, and 29 Post-Vaccination 1 (Day 2, 4, 8, and 29, respectively); Days 2, 4, and 8 Post-Vaccination 2 (Day 30, 32, and 36, respectively)	Venous blood samples for plasma were used for this assay. A Luminex assay was used to measure concentrations in ng/L. Concentrations for 9 of the total 24 cytokines and chemokines were measured: Interleukin 21 (IL-21), Interleukin 23 (IL-23), Interleukin 4 (IL-4), Interleukin 5 (IL-5), Interleukin 6 (IL-6), Interleukin 7 (IL-7), Interleukin 8 (IL-8), Interleukin 12, p70 (IL-12p70), and Interleukin 17A (IL-17A). If no cytokine or chemokine measurements were collected, number of participants is reported as 0.

Countries

United States

Participant flow

Recruitment details

Participants were healthy males and non-pregnant females aged 18 to 49 years old, inclusively. They were recruited from the community at large around the clinic site. Participants were enrolled between 07NOV2016 and 31JAN2017.

Participants by arm

Arm	Count
A/H3N2v One dose of 15 ug of A/H3N2v, at Day 1 A/H3N2v influenza virus vaccine: Monovalent inactivated influenza A/H3N2v virus vaccine (A/Minnesota/11/2010).	10
A/H7N9 + AS03 Two doses of 3.75 ug of A/H7N9 + AS03, at Day 1 and Day 29 (+/- 2 days) AS03: AS03 oil-in-water emulsion adjuvant. A/H7N9 influenza virus vaccine: Monovalent inactivated influenza A/H7N9 virus vaccine (A/Shanghai/2/2013)	10
A/H7N9 Two doses of 3.75 ug of A/H7N9, at Day 1 and Day 29 (+/- 2 days) A/H7N9 influenza virus vaccine: Monovalent inactivated influenza A/H7N9 virus vaccine (A/Shanghai/2/2013)	10
Total	30

Baseline characteristics

Characteristic	A/H7N9	Total	A/H3N2v	A/H7N9 + AS03
Age, Categorical <=18 years	0 Participants	0 Participants	0 Participants	0 Participants
Age, Categorical >=65 years	0 Participants	0 Participants	0 Participants	0 Participants
Age, Categorical Between 18 and 65 years	10 Participants	30 Participants	10 Participants	10 Participants
Age, Continuous	33.7 years STANDARD_DEVIATION 8.3	30.9 years STANDARD_DEVIATION 7.4	31.0 years STANDARD_DEVIATION 7.1	28.0 years STANDARD_DEVIATION 6.2
BMI	28.453 kg/m^2 STANDARD_DEVIATION 10.768	24.821 kg/m^2 STANDARD_DEVIATION 7.443	24.125 kg/m^2 STANDARD_DEVIATION 5.609	21.885 kg/m^2 STANDARD_DEVIATION 2.52
Ethnicity (NIH/OMB) Hispanic or Latino	0 Participants	0 Participants	0 Participants	0 Participants
Ethnicity (NIH/OMB) Not Hispanic or Latino	10 Participants	30 Participants	10 Participants	10 Participants
Ethnicity (NIH/OMB) Unknown or Not Reported	0 Participants	0 Participants	0 Participants	0 Participants
Race (NIH/OMB) American Indian or Alaska Native	0 Participants	0 Participants	0 Participants	0 Participants
Race (NIH/OMB) Asian	0 Participants	0 Participants	0 Participants	0 Participants
Race (NIH/OMB) Black or African American	0 Participants	0 Participants	0 Participants	0 Participants
Race (NIH/OMB) More than one race	0 Participants	0 Participants	0 Participants	0 Participants
Race (NIH/OMB) Native Hawaiian or Other Pacific Islander	0 Participants	0 Participants	0 Participants	0 Participants
Race (NIH/OMB) Unknown or Not Reported	0 Participants	0 Participants	0 Participants	0 Participants
Race (NIH/OMB) White	10 Participants	30 Participants	10 Participants	10 Participants
Region of Enrollment United States	10 participants	30 participants	10 participants	10 participants
Sex: Female, Male Female	5 Participants	19 Participants	7 Participants	7 Participants
Sex: Female, Male Male	5 Participants	11 Participants	3 Participants	3 Participants

Adverse events

Event type	EG000 affected / at risk	EG001 affected / at risk	EG002 affected / at risk
deaths Total, all-cause mortality	0 / 10	0 / 10	0 / 10
other Total, other adverse events	8 / 10	10 / 10	7 / 10
serious Total, serious adverse events	0 / 10	0 / 10	1 / 10

Outcome results

Primary

Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)

RNA expression levels (read counts) for each gene were determined by RNA-Sequencing of RNA extracted from six separated cell types: monocytes , dendritic cells, neutrophils, NK cells, B cells, and T cells. Post-vaccination gene expression levels were compared to pre-vaccination gene expression levels (combined summed read counts for Day -7 and Day 1 samples for post-vaccination 1 timepoints and Day 29 read counts for post-vaccination 2 timepoints) using a negative binomial model to identify differentially expressed (DE) genes (FDR-adjusted p-value \< 0.05 and mean fold change =\> 1.5 in either direction).

Time frame: Days 2, 4, and 29 Post-Vaccination 1 (Day 2, 4, and 29, respectively); Days 2, 4, and 8 Post-Vaccination 2 (Day 30, 32, and 36, respectively)

Population: The transcriptomics analysis population, A/H7N9 + AS03 and A/H7N9 arms: Includes all participants in the A/H7N9 +AS03 and A/H7N9 arms who received at least one study vaccination and contributed at least one pre- and one post-vaccination sample for transcriptomics testing for which valid results were reported.

Arm	Measure	Group	Value (NUMBER)
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	NK cells : Day 2 Post Vaccination 1	60 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	Monocytes : Day 8 Post Vaccination 2	4 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	NK cells : Day 4 Post Vaccination 1	66 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	Dendritic cells : Day 4 Post Vaccination 2	25 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	NK cells : Day 29 Post Vaccination 1	8 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	Monocytes : Day 2 Post Vaccination 2	1418 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	NK cells : Day 2 Post Vaccination 2	303 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	Dendritic cells : Day 8 Post Vaccination 2	170 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	NK cells : Day 4 Post Vaccination 2	396 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	Dendritic cells : Day 2 Post Vaccination 1	1091 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	NK cells : Day 8 Post Vaccination 2	166 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	Neutrophils : Day 2 Post Vaccination 1	1116 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	B cells : Day 2 Post Vaccination 1	51 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	Monocytes : Day 29 Post Vaccination 1	0 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	B cells : Day 4 Post Vaccination 1	1 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	Neutrophils : Day 4 Post Vaccination 1	41 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	B cells : Day 29 Post Vaccination 1	1 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	Dendritic cells : Day 4 Post Vaccination 1	8 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	B cells : Day 2 Post Vaccination 2	345 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	Neutrophils : Day 29 Post Vaccination 1	0 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	B cells : Day 4 Post Vaccination 2	99 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	Monocytes : Day 4 Post Vaccination 2	26 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	B cells : Day 8 Post Vaccination 2	67 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	Neutrophils : Day 2 Post Vaccination 2	2044 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	T cells : Day 2 Post Vaccination 1	88 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	Dendritic cells : Day 29 Post Vaccination 1	1 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	T cells : Day 4 Post Vaccination 1	0 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	Neutrophils : Day 4 Post Vaccination 2	181 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	T cells : Day 29 Post Vaccination 1	1 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	Monocytes : Day 4 Post Vaccination 1	36 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	T cells : Day 2 Post Vaccination 2	301 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	Neutrophils : Day 8 Post Vaccination 2	0 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	T cells : Day 4 Post Vaccination 2	3 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	Dendritic cells : Day 2 Post Vaccination 2	1953 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	T cells : Day 8 Post Vaccination 2	3 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	Monocytes : Day 2 Post Vaccination 1	618 Number of DE genes
A/H7N9	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	T cells : Day 8 Post Vaccination 2	0 Number of DE genes
A/H7N9	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	Monocytes : Day 2 Post Vaccination 1	0 Number of DE genes
A/H7N9	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	Monocytes : Day 4 Post Vaccination 1	0 Number of DE genes
A/H7N9	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	Monocytes : Day 29 Post Vaccination 1	0 Number of DE genes
A/H7N9	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	Monocytes : Day 2 Post Vaccination 2	0 Number of DE genes
A/H7N9	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	Monocytes : Day 4 Post Vaccination 2	0 Number of DE genes
A/H7N9	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	Monocytes : Day 8 Post Vaccination 2	0 Number of DE genes
A/H7N9	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	Dendritic cells : Day 2 Post Vaccination 1	0 Number of DE genes
A/H7N9	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	Dendritic cells : Day 4 Post Vaccination 1	0 Number of DE genes
A/H7N9	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	Dendritic cells : Day 29 Post Vaccination 1	0 Number of DE genes
A/H7N9	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	Dendritic cells : Day 2 Post Vaccination 2	0 Number of DE genes
A/H7N9	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	Dendritic cells : Day 4 Post Vaccination 2	0 Number of DE genes
A/H7N9	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	Dendritic cells : Day 8 Post Vaccination 2	0 Number of DE genes
A/H7N9	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	Neutrophils : Day 2 Post Vaccination 1	0 Number of DE genes
A/H7N9	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	Neutrophils : Day 4 Post Vaccination 1	0 Number of DE genes
A/H7N9	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	Neutrophils : Day 29 Post Vaccination 1	0 Number of DE genes
A/H7N9	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	Neutrophils : Day 2 Post Vaccination 2	0 Number of DE genes
A/H7N9	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	Neutrophils : Day 4 Post Vaccination 2	0 Number of DE genes
A/H7N9	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	Neutrophils : Day 8 Post Vaccination 2	0 Number of DE genes
A/H7N9	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	NK cells : Day 2 Post Vaccination 1	0 Number of DE genes
A/H7N9	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	NK cells : Day 4 Post Vaccination 1	0 Number of DE genes
A/H7N9	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	NK cells : Day 29 Post Vaccination 1	0 Number of DE genes
A/H7N9	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	NK cells : Day 2 Post Vaccination 2	2 Number of DE genes
A/H7N9	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	NK cells : Day 4 Post Vaccination 2	0 Number of DE genes
A/H7N9	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	NK cells : Day 8 Post Vaccination 2	0 Number of DE genes
A/H7N9	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	B cells : Day 2 Post Vaccination 1	0 Number of DE genes
A/H7N9	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	B cells : Day 4 Post Vaccination 1	1 Number of DE genes
A/H7N9	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	B cells : Day 29 Post Vaccination 1	0 Number of DE genes
A/H7N9	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	B cells : Day 2 Post Vaccination 2	0 Number of DE genes
A/H7N9	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	B cells : Day 4 Post Vaccination 2	0 Number of DE genes
A/H7N9	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	B cells : Day 8 Post Vaccination 2	0 Number of DE genes
A/H7N9	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	T cells : Day 2 Post Vaccination 1	0 Number of DE genes
A/H7N9	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	T cells : Day 4 Post Vaccination 1	1 Number of DE genes
A/H7N9	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	T cells : Day 29 Post Vaccination 1	0 Number of DE genes
A/H7N9	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	T cells : Day 2 Post Vaccination 2	0 Number of DE genes
A/H7N9	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)	T cells : Day 4 Post Vaccination 2	0 Number of DE genes

Primary

Percentage of Participants Achieving Seroconversion Based on HAI Titer (A/H3N2v Vaccine)

Seroconversion is defined as either a pre-vaccination HAI titer \<1:10 and a post-vaccination HAI titer =\>1:40 or a pre-vaccination HAI titer =\>1:10 and a minimum four-fold rise in post-vaccination HAI antibody titer. Venous blood samples for serum were used for this assay. HAI based on the H3N2 strain A/Minnesota/11/2010 were assessed.

Time frame: Day 29 Post-Vaccination 1 (Day 29)

Population: The intent-to-treat (ITT) population, A/H3N2v arm: Includes all participants in the A/H3N2v arm who received at least one dose of study vaccine and contributed both pre- and at least one post-study vaccination blood samples for serological assessment (HAI or Neut antibody assays) for which valid results were reported.

Arm	Measure	Value (NUMBER)
A/H7N9 + AS03	Percentage of Participants Achieving Seroconversion Based on HAI Titer (A/H3N2v Vaccine)	50 percentage of participants

Primary

Percentage of Participants Achieving Seroconversion Based on HAI Titer (A/H7N9 Vaccine, With and Without Adjuvant)

Time frame: Day 29 Post-Vaccination 2 (Day 57)

Population: The intent-to-treat (ITT) population, A/H7N9 + AS03 and A/H7N9 arms: Includes all participants in the A/H7N9 + AS03 and A/H7N9 arms who received at least one dose of study vaccine and contributed both pre- and at least one post-study vaccination blood samples for serological assessment (HAI or Neut antibody assays) for which valid results were reported.

Arm	Measure	Value (NUMBER)
A/H7N9 + AS03	Percentage of Participants Achieving Seroconversion Based on HAI Titer (A/H7N9 Vaccine, With and Without Adjuvant)	80.0 percentage of participants
A/H7N9	Percentage of Participants Achieving Seroconversion Based on HAI Titer (A/H7N9 Vaccine, With and Without Adjuvant)	0 percentage of participants

Secondary

Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1

Venous blood samples for plasma were used for this assay. A Luminex assay was used to measure concentrations in ng/L. Concentrations for 11 of the total 24 cytokines and chemokines were measured: Fractalkine, Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF), Interferon-Gamma-Induced Protein-10(IP-10), Interferon-Alpha (IFNa), Interferon-Beta (IFNb), Interferon-Gamma (IFNy), Interferon-inducible T Cell Alpha Chemoattractant (ITAC), Interleukin 1 Beta (IL-1b), Interleukin 10 (IL-10), Interleukin 13 (IL-13), and Interleukin 2 (IL-2). If no cytokine or chemokine measurements were collected, number of participants is reported as 0.

Time frame: Day 1 Pre-Vaccination 1; Days 2, 4, 8, and 29 Post-Vaccination 1 (Day 2, 4, 8, and 29, respectively); Days 2, 4, and 8 Post-Vaccination 2 (Day 30, 32, and 36, respectively)

Arm	Measure	Group	Value (MEDIAN)
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	Fractalkine : Day 1 Pre-Vaccination	310.9 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	Fractalkine : Day 2 Post-Vaccination 1	312.26 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	Fractalkine : Day 4 Post-Vaccination 1	345.14 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	Fractalkine : Day 8 Post-Vaccination 1	370.77 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	GM-CSF : Day 1 Pre-Vaccination	511.59 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	GM-CSF : Day 2 Post-Vaccination 1	557.77 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	GM-CSF : Day 4 Post-Vaccination 1	561.63 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	GM-CSF : Day 8 Post-Vaccination 1	494.07 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IP-10 : Day 1 Pre-Vaccination	249.16 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IP-10 : Day 2 Post-Vaccination 1	261.78 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IP-10 : Day 4 Post-Vaccination 1	242.77 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IP-10 : Day 8 Post-Vaccination 1	236.95 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNa : Day 1 Pre-Vaccination	116.80 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNa : Day 2 Post-Vaccination 1	73.98 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNa : Day 4 Post-Vaccination 1	66.93 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNa : Day 8 Post-Vaccination 1	89.29 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNb : Day 1 Pre-Vaccination	1073.70 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNb : Day 2 Post-Vaccination 1	1023.11 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNy : Day 1 Pre-Vaccination	28.71 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNy : Day 2 Post-Vaccination 1	26.47 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNy : Day 4 Post-Vaccination 1	26.38 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNb : Day 4 Post-Vaccination 1	878.76 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNb : Day 8 Post-Vaccination 1	1104.00 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNy : Day 8 Post-Vaccination 1	30.98 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	ITAC : Day 1 Pre-Vaccination	58.19 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	ITAC : Day 2 Post-Vaccination 1	56.31 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	ITAC : Day 4 Post-Vaccination 1	51.68 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	ITAC : Day 8 Post-Vaccination 1	49.21 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-10 : Day 4 Post-Vaccination 1	22.29 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-1b : Day 1 Pre-Vaccination	2.84 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-1b : Day 2 Post-Vaccination 1	2.62 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-1b : Day 4 Post-Vaccination 1	2.78 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-1b : Day 8 Post-Vaccination 1	2.82 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-10 : Day 8 Post-Vaccination 1	19.52 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-13 : Day 1 Pre-Vaccination	11.24 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-13 : Day 2 Post-Vaccination 1	10.98 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-13 : Day 4 Post-Vaccination 1	13.86 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-13 : Day 8 Post-Vaccination 1	11.02 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-2 : Day 1 Pre-Vaccination	3.30 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-2 : Day 2 Post-Vaccination 1	4.13 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-2 : Day 4 Post-Vaccination 1	3.43 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-2 : Day 8 Post-Vaccination 1	2.99 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-10 : Day 1 Pre-Vaccination	21.92 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-10 : Day 2 Post-Vaccination 1	22.26 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-10 : Day 2 Post-Vaccination 1	17.16 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNa : Day 4 Post-Vaccination 1	125.29 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-2 : Day 2 Post-Vaccination 2	2.39 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-13 : Day 4 Post-Vaccination 2	17.56 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	ITAC : Day 4 Post-Vaccination 2	58.32 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNy : Day 2 Post-Vaccination 1	21.22 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	ITAC : Day 8 Post-Vaccination 2	50.94 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNa : Day 1 Pre-Vaccination	142.43 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-2 : Day 2 Post-Vaccination 1	2.52 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-1b : Day 1 Pre-Vaccination	2.83 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNa : Day 29 Post-Vaccination 1	118.90 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-2 : Day 4 Post-Vaccination 2	2.71 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-1b : Day 2 Post-Vaccination 1	2.33 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IP-10 : Day 4 Post-Vaccination 2	512.16 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNb : Day 4 Post-Vaccination 1	1074.52 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-1b : Day 4 Post-Vaccination 1	3.46 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNa : Day 2 Post-Vaccination 2	130.25 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-2 : Day 8 Post-Vaccination 2	3.14 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-1b : Day 29 Post-Vaccination 1	3.25 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNb : Day 29 Post-Vaccination 1	1185.00 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-10 : Day 4 Post-Vaccination 1	17.64 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNy : Day 4 Post-Vaccination 1	19.01 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNa : Day 4 Post-Vaccination 2	127.23 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-10 : Day 29 Post-Vaccination 1	19.93 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-2 : Day 4 Post-Vaccination 1	2.28 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-10 : Day 2 Post-Vaccination 2	23.79 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNy : Day 29 Post-Vaccination 1	23.07 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-10 : Day 4 Post-Vaccination 2	19.29 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IP-10 : Day 2 Post-Vaccination 2	1264.00 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-10 : Day 8 Post-Vaccination 2	21.75 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNy : Day 2 Post-Vaccination 2	37.22 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-1b : Day 2 Post-Vaccination 2	2.99 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-13 : Day 1 Pre-Vaccination	18.39 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNb : Day 2 Post-Vaccination 2	1188.50 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	Fractalkine : Day 1 Pre-Vaccination	288.58 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNa : Day 8 Post-Vaccination 2	163.86 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNb : Day 4 Post-Vaccination 2	1027.74 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	Fractalkine : Day 2 Post-Vaccination 1	224.58 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IP-10 : Day 8 Post-Vaccination 2	307.23 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-13 : Day 2 Post-Vaccination 1	20.66 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	Fractalkine : Day 4 Post-Vaccination 1	378.46 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-1b : Day 8 Post-Vaccination 2	2.52 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNy : Day 4 Post-Vaccination 2	19.99 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	Fractalkine : Day 29 Post-Vaccination 1	353.48 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNb : Day 1 Pre-Vaccination	1211.25 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	Fractalkine : Day 2 Post-Vaccination 2	282.53 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNy : Day 8 Post-Vaccination 2	18.00 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	Fractalkine : Day 4 Post-Vaccination 2	311.15 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNa : Day 2 Post-Vaccination 1	132.03 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	Fractalkine : Day 8 Post-Vaccination 2	318.38 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-2 : Day 1 Pre-Vaccination	2.49 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-1b : Day 4 Post-Vaccination 2	2.81 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	GM-CSF : Day 1 Pre-Vaccination	290.44 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	ITAC : Day 1 Pre-Vaccination	44.19 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-13 : Day 4 Post-Vaccination 1	21.10 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	GM-CSF : Day 2 Post-Vaccination 1	301.31 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNb : Day 2 Post-Vaccination 1	1068.38 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-10 : Day 1 Pre-Vaccination	18.28 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	GM-CSF : Day 4 Post-Vaccination 1	286.35 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	ITAC : Day 2 Post-Vaccination 1	52.46 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNb : Day 8 Post-Vaccination 2	992.82 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	GM-CSF : Day 29 Post-Vaccination 1	324.61 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-2 : Day 29 Post-Vaccination 1	2.29 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	GM-CSF : Day 2 Post-Vaccination 2	313.25 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	ITAC : Day 4 Post-Vaccination 1	47.38 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	GM-CSF : Day 4 Post-Vaccination 2	259.34 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IP-10 : Day 29 Post-Vaccination 1	284.62 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	GM-CSF : Day 8 Post-Vaccination 2	276.04 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-13 : Day 8 Post-Vaccination 2	21.50 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-13 : Day 29 Post-Vaccination 1	19.35 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IP-10 : Day 1 Pre-Vaccination	288.09 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	ITAC : Day 29 Post-Vaccination 1	60.62 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNy : Day 1 Pre-Vaccination	17.86 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IP-10 : Day 2 Post-Vaccination 1	535.80 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	ITAC : Day 2 Post-Vaccination 2	77.16 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-13 : Day 2 Post-Vaccination 2	18.99 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IP-10 : Day 4 Post-Vaccination 1	417.82 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-13 : Day 4 Post-Vaccination 1	11.51 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-13 : Day 2 Post-Vaccination 2	10.79 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IP-10 : Day 29 Post-Vaccination 1	212.26 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IP-10 : Day 2 Post-Vaccination 2	234.75 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IP-10 : Day 4 Post-Vaccination 2	224.40 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IP-10 : Day 8 Post-Vaccination 2	220.60 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNa : Day 1 Pre-Vaccination	104.81 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNb : Day 29 Post-Vaccination 1	1109.00 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-13 : Day 4 Post-Vaccination 2	10.08 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNa : Day 2 Post-Vaccination 1	101.40 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNa : Day 4 Post-Vaccination 1	86.82 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-13 : Day 8 Post-Vaccination 2	10.36 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNa : Day 29 Post-Vaccination 1	111.00 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNa : Day 2 Post-Vaccination 2	89.99 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNa : Day 4 Post-Vaccination 2	113.26 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNa : Day 8 Post-Vaccination 2	89.00 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNb : Day 1 Pre-Vaccination	989.57 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNb : Day 8 Post-Vaccination 2	1326.50 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-2 : Day 1 Pre-Vaccination	4.48 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNy : Day 1 Pre-Vaccination	33.82 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-1b : Day 8 Post-Vaccination 2	3.03 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNy : Day 2 Post-Vaccination 1	33.17 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNb : Day 2 Post-Vaccination 1	1106.50 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-2 : Day 2 Post-Vaccination 1	4.32 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNb : Day 4 Post-Vaccination 1	1045.50 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-10 : Day 1 Pre-Vaccination	27.67 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNy : Day 4 Post-Vaccination 1	33.74 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNy : Day 29 Post-Vaccination 1	32.43 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNb : Day 2 Post-Vaccination 2	1241.50 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNb : Day 4 Post-Vaccination 2	980.99 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNy : Day 2 Post-Vaccination 2	30.79 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNy : Day 4 Post-Vaccination 2	29.70 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IFNy : Day 8 Post-Vaccination 2	28.94 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-2 : Day 4 Post-Vaccination 1	3.82 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	ITAC : Day 1 Pre-Vaccination	52.62 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	ITAC : Day 2 Post-Vaccination 1	49.22 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	ITAC : Day 4 Post-Vaccination 1	52.83 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-2 : Day 29 Post-Vaccination 1	4.68 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	ITAC : Day 29 Post-Vaccination 1	49.58 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-10 : Day 2 Post-Vaccination 1	26.04 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	ITAC : Day 2 Post-Vaccination 2	45.04 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	ITAC : Day 4 Post-Vaccination 2	34.97 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	ITAC : Day 8 Post-Vaccination 2	47.67 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-2 : Day 2 Post-Vaccination 2	4.05 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-1b : Day 1 Pre-Vaccination	3.33 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-1b : Day 2 Post-Vaccination 1	3.46 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-2 : Day 4 Post-Vaccination 2	3.74 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-1b : Day 4 Post-Vaccination 1	3.39 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-1b : Day 29 Post-Vaccination 1	3.70 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-10 : Day 4 Post-Vaccination 1	29.53 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-2 : Day 8 Post-Vaccination 2	3.97 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-10 : Day 29 Post-Vaccination 1	26.71 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-10 : Day 2 Post-Vaccination 2	24.57 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-10 : Day 4 Post-Vaccination 2	26.39 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-10 : Day 8 Post-Vaccination 2	23.29 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-13 : Day 1 Pre-Vaccination	12.46 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	Fractalkine : Day 1 Pre-Vaccination	356.19 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-1b : Day 2 Post-Vaccination 2	3.88 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	Fractalkine : Day 2 Post-Vaccination 1	315.31 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	Fractalkine : Day 4 Post-Vaccination 1	309.48 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-13 : Day 2 Post-Vaccination 1	11.72 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	Fractalkine : Day 29 Post-Vaccination 1	333.38 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	Fractalkine : Day 2 Post-Vaccination 2	305.83 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	Fractalkine : Day 4 Post-Vaccination 2	316.25 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	Fractalkine : Day 8 Post-Vaccination 2	306.53 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	GM-CSF : Day 1 Pre-Vaccination	478.50 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	GM-CSF : Day 2 Post-Vaccination 1	478.66 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IP-10 : Day 4 Post-Vaccination 1	219.79 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	GM-CSF : Day 4 Post-Vaccination 1	448.62 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-1b : Day 4 Post-Vaccination 2	3.16 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	GM-CSF : Day 29 Post-Vaccination 1	476.40 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	GM-CSF : Day 2 Post-Vaccination 2	497.90 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	GM-CSF : Day 4 Post-Vaccination 2	468.16 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	GM-CSF : Day 8 Post-Vaccination 2	468.95 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IP-10 : Day 1 Pre-Vaccination	238.80 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IL-13 : Day 29 Post-Vaccination 1	10.80 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1	IP-10 : Day 2 Post-Vaccination 1	273.48 ng/L

Secondary

Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2

Venous blood samples for plasma were used for this assay. A Luminex assay was used to measure concentrations in ng/L. Concentrations for 9 of the total 24 cytokines and chemokines were measured: Interleukin 21 (IL-21), Interleukin 23 (IL-23), Interleukin 4 (IL-4), Interleukin 5 (IL-5), Interleukin 6 (IL-6), Interleukin 7 (IL-7), Interleukin 8 (IL-8), Interleukin 12, p70 (IL-12p70), and Interleukin 17A (IL-17A). If no cytokine or chemokine measurements were collected, number of participants is reported as 0.

Time frame: Day 1 Pre-Vaccination 1; Days 2, 4, 8, and 29 Post-Vaccination 1 (Day 2, 4, 8, and 29, respectively); Days 2, 4, and 8 Post-Vaccination 2 (Day 30, 32, and 36, respectively)

Population: The intent-to-treat (ITT) population: Includes all participants who received at least one dose of study vaccine and contributed both pre- and at least one post-study vaccination blood samples for serological assessment (HAI or Neut antibody assays) for which valid results were reported. No cytokine or chemokine measurements were collected for the A/H3N2v arm after Day 8 Post-Vaccination 1 (Day 8), and for the A/H7N9 + AS03 and A/H7N9 arms at Day 8 Post-Vaccination 1 (Day 8).

Arm	Measure	Group	Value (MEDIAN)
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-4 : Day 1 Pre-Vaccination	61.67 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-12p70 : Day 4 Post-Vaccination 1	3.95 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-7 : Day 2 Post-Vaccination 1	3.90 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-4 : Day 2 Post-Vaccination 1	69.57 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-21 : Day 1 Pre-Vaccination	3.54 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-7 : Day 1 Pre-Vaccination	4.02 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-4 : Day 4 Post-Vaccination 1	68.54 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-21 : Day 2 Post-Vaccination 1	3.83 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-6 : Day 8 Post-Vaccination 1	2.28 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-4 : Day 8 Post-Vaccination 1	63.89 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-12p70 : Day 2 Post-Vaccination 1	3.93 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-6 : Day 4 Post-Vaccination 1	2.09 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-23 : Day 1 Pre-Vaccination	367.05 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-6 : Day 2 Post-Vaccination 1	2.03 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-17A : Day 2 Post-Vaccination 1	18.06 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-6 : Day 1 Pre-Vaccination	2.02 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-12p70 : Day 1 Pre-Vaccination	3.96 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-5 : Day 8 Post-Vaccination 1	2.50 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-5 : Day 1 Pre-Vaccination	3.22 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-23 : Day 2 Post-Vaccination 1	304.56 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-5 : Day 4 Post-Vaccination 1	2.96 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-5 : Day 2 Post-Vaccination 1	3.04 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-21 : Day 8 Post-Vaccination 1	2.76 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-8 : Day 8 Post-Vaccination 1	4.35 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-23 : Day 4 Post-Vaccination 1	419.28 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-17A : Day 8 Post-Vaccination 1	22.21 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-8 : Day 4 Post-Vaccination 1	4.86 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-23 : Day 8 Post-Vaccination 1	339.06 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-17A: Day 1 Pre-Vaccination	19.44 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-8 : Day 2 Post-Vaccination 1	5.04 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-17A : Day 4 Post-Vaccination 1	20.03 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-8 : Day 1 Pre-Vaccination	4.37 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-12p70 : Day 8 Post-Vaccination 1	4.63 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-7 : Day 8 Post-Vaccination 1	3.89 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-21 : Day 4 Post-Vaccination 1	4.47 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-7 : Day 4 Post-Vaccination 1	3.71 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-4 : Day 2 Post-Vaccination 1	53.00 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-21 : Day 1 Pre-Vaccination	3.25 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-21 : Day 2 Post-Vaccination 1	3.00 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-21 : Day 4 Post-Vaccination 1	2.76 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-21 : Day 29 Post-Vaccination 1	4.76 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-21 : Day 2 Post-Vaccination 2	4.29 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-21 : Day 4 Post-Vaccination 2	3.96 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-21 : Day 8 Post-Vaccination 2	2.85 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-23 : Day 1 Pre-Vaccination	368.23 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-23 : Day 2 Post-Vaccination 1	362.33 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-23 : Day 4 Post-Vaccination 1	468.30 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-23 : Day 29 Post-Vaccination 1	418.57 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-23 : Day 2 Post-Vaccination 2	487.09 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-23 : Day 4 Post-Vaccination 2	409.82 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-23 : Day 8 Post-Vaccination 2	421.69 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-4 : Day 1 Pre-Vaccination	49.85 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-4 : Day 4 Post-Vaccination 1	53.75 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-4 : Day 29 Post-Vaccination 1	59.46 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-4 : Day 2 Post-Vaccination 2	66.66 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-4 : Day 4 Post-Vaccination 2	67.74 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-4 : Day 8 Post-Vaccination 2	54.44 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-5 : Day 1 Pre-Vaccination	3.92 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-5 : Day 2 Post-Vaccination 1	4.54 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-5 : Day 4 Post-Vaccination 1	4.73 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-5 : Day 29 Post-Vaccination 1	4.56 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-5 : Day 2 Post-Vaccination 2	4.83 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-5 : Day 4 Post-Vaccination 2	4.15 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-5 : Day 8 Post-Vaccination 2	4.78 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-6 : Day 1 Pre-Vaccination	1.26 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-6 : Day 2 Post-Vaccination 1	2.54 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-6 : Day 4 Post-Vaccination 1	1.48 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-6 : Day 29 Post-Vaccination 1	1.75 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-6 : Day 2 Post-Vaccination 2	2.95 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-6 : Day 4 Post-Vaccination 2	1.48 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-6 : Day 8 Post-Vaccination 2	1.07 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-7 : Day 1 Pre-Vaccination	4.58 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-7 : Day 2 Post-Vaccination 1	4.05 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-7 : Day 4 Post-Vaccination 1	4.93 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-7 : Day 29 Post-Vaccination 1	5.85 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-7 : Day 2 Post-Vaccination 2	6.20 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-7 : Day 4 Post-Vaccination 2	5.56 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-7 : Day 8 Post-Vaccination 2	5.46 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-8 : Day 1 Pre-Vaccination	6.97 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-8 : Day 2 Post-Vaccination 1	6.76 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-8 : Day 4 Post-Vaccination 1	7.47 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-8 : Day 29 Post-Vaccination 1	7.42 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-8 : Day 2 Post-Vaccination 2	8.41 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-8 : Day 4 Post-Vaccination 2	7.03 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-8 : Day 8 Post-Vaccination 2	5.64 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-12p70 : Day 1 Pre-Vaccination	2.53 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-12p70 : Day 2 Post-Vaccination 1	2.50 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-12p70 : Day 4 Post-Vaccination 1	2.68 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-12p70 : Day 29 Post-Vaccination 1	3.65 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-12p70 : Day 2 Post-Vaccination 2	3.83 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-12p70 : Day 4 Post-Vaccination 2	3.69 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-12p70 : Day 8 Post-Vaccination 2	2.18 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-17A: Day 1 Pre-Vaccination	14.04 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-17A : Day 2 Post-Vaccination 1	15.12 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-17A : Day 4 Post-Vaccination 1	14.86 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-17A : Day 29 Post-Vaccination 1	17.44 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-17A : Day 2 Post-Vaccination 2	18.69 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-17A : Day 4 Post-Vaccination 2	16.66 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-17A : Day 8 Post-Vaccination 2	13.24 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-23 : Day 4 Post-Vaccination 2	514.30 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-12p70 : Day 29 Post-Vaccination 1	5.63 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-7 : Day 29 Post-Vaccination 1	4.99 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-17A : Day 4 Post-Vaccination 1	22.84 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-7 : Day 2 Post-Vaccination 2	4.41 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-12p70 : Day 2 Post-Vaccination 2	5.01 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-7 : Day 4 Post-Vaccination 2	4.83 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-21 : Day 1 Pre-Vaccination	2.43 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-7 : Day 8 Post-Vaccination 2	4.03 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-23 : Day 2 Post-Vaccination 2	536.87 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-12p70 : Day 4 Post-Vaccination 2	4.44 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-8 : Day 1 Pre-Vaccination	5.53 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-23 : Day 29 Post-Vaccination 1	496.08 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-17A : Day 8 Post-Vaccination 2	21.34 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-8 : Day 2 Post-Vaccination 1	5.04 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-23 : Day 4 Post-Vaccination 1	583.59 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-12p70 : Day 8 Post-Vaccination 2	5.08 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-8 : Day 4 Post-Vaccination 1	5.33 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-23 : Day 2 Post-Vaccination 1	490.16 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-21 : Day 29 Post-Vaccination 1	2.53 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-8 : Day 29 Post-Vaccination 1	4.53 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-17A : Day 29 Post-Vaccination 1	23.83 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-8 : Day 8 Post-Vaccination 2	4.44 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-5 : Day 2 Post-Vaccination 1	2.84 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-5 : Day 1 Pre-Vaccination	2.82 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-8 : Day 2 Post-Vaccination 2	4.84 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-5 : Day 4 Post-Vaccination 1	3.03 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-4 : Day 8 Post-Vaccination 2	63.96 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-17A: Day 1 Pre-Vaccination	24.34 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-5 : Day 29 Post-Vaccination 1	3.33 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-8 : Day 4 Post-Vaccination 2	4.70 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-5 : Day 2 Post-Vaccination 2	3.03 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-21 : Day 4 Post-Vaccination 1	2.64 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-5 : Day 4 Post-Vaccination 2	3.04 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-23 : Day 1 Pre-Vaccination	550.19 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-5 : Day 8 Post-Vaccination 2	3.25 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-4 : Day 4 Post-Vaccination 2	59.86 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-17A : Day 4 Post-Vaccination 2	21.67 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-6 : Day 1 Pre-Vaccination	3.39 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-4 : Day 2 Post-Vaccination 2	61.47 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-12p70 : Day 1 Pre-Vaccination	5.33 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-6 : Day 2 Post-Vaccination 1	3.23 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-4 : Day 29 Post-Vaccination 1	59.83 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-21 : Day 8 Post-Vaccination 2	1.93 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-6 : Day 4 Post-Vaccination 1	3.39 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-4 : Day 4 Post-Vaccination 1	58.21 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-17A : Day 2 Post-Vaccination 1	20.96 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-6 : Day 29 Post-Vaccination 1	3.52 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-12p70 : Day 2 Post-Vaccination 1	4.18 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-6 : Day 2 Post-Vaccination 2	3.09 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-21 : Day 4 Post-Vaccination 2	2.01 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-6 : Day 4 Post-Vaccination 2	3.06 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-21 : Day 2 Post-Vaccination 1	2.63 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-6 : Day 8 Post-Vaccination 2	3.11 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-4 : Day 2 Post-Vaccination 1	63.35 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-12p70 : Day 4 Post-Vaccination 1	4.90 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-7 : Day 1 Pre-Vaccination	5.22 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-4 : Day 1 Pre-Vaccination	59.30 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-21 : Day 2 Post-Vaccination 2	2.09 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-7 : Day 2 Post-Vaccination 1	5.12 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-23 : Day 8 Post-Vaccination 2	444.43 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-17A : Day 2 Post-Vaccination 2	23.50 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2	IL-7 : Day 4 Post-Vaccination 1	4.97 ng/L

Secondary

Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3

Venous blood samples for plasma were used for this assay. A Luminex assay was used to measure concentrations in ng/L. Concentrations for 4 of the total 24 cytokines and chemokines were measured: Macrophage Inflammatory Protein-1 Alpha (MIP1a), Macrophage Inflammatory Protein-1 Beta (MIP1b), Macrophage Inflammatory Protein-3 Alpha (MIP3a), and Tumor Necrosis Factor Alpha (TNF-a). If no cytokine or chemokine measurements were collected, number of participants is reported as 0.

Time frame: Day 1 Pre-Vaccination 1; Days 2, 4, 8, and 29 Post-Vaccination 1 (Day 2, 4, 8, and 29, respectively); Days 2, 4, and 8 Post-Vaccination 2 (Day 30, 32, and 36, respectively)

Arm	Measure	Group	Value (MEDIAN)
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP1b : Day 1 Pre-Vaccination	18.63 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP1a : Day 4 Post-Vaccination 1	23.86 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP1a : Day 1 Pre-Vaccination	25.49 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP1a : Day 2 Post-Vaccination 1	24.56 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP1a : Day 8 Post-Vaccination 1	27.64 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP1b : Day 2 Post-Vaccination 1	20.43 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP1b : Day 4 Post-Vaccination 1	20.47 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP1b : Day 8 Post-Vaccination 1	23.67 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP3a : Day 1 Pre-Vaccination	16.77 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP3a : Day 2 Post-Vaccination 1	19.59 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP3a : Day 4 Post-Vaccination 1	18.58 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP3a : Day 8 Post-Vaccination 1	18.62 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	TNF-a : Day 1 Pre-Vaccination	4.32 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	TNF-a : Day 2 Post-Vaccination 1	5.13 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	TNF-a : Day 4 Post-Vaccination 1	5.16 ng/L
A/H7N9 + AS03	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	TNF-a : Day 8 Post-Vaccination 1	4.48 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP1b : Day 2 Post-Vaccination 2	29.05 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP1a : Day 1 Pre-Vaccination	24.86 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP3a : Day 29 Post-Vaccination 1	15.72 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP1b : Day 4 Post-Vaccination 2	14.42 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP3a : Day 2 Post-Vaccination 2	16.24 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP1b : Day 4 Post-Vaccination 1	14.76 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP3a : Day 4 Post-Vaccination 2	16.24 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP1b : Day 8 Post-Vaccination 2	16.18 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP3a : Day 8 Post-Vaccination 2	19.01 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	TNF-a : Day 4 Post-Vaccination 1	4.78 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	TNF-a : Day 4 Post-Vaccination 2	5.28 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	TNF-a : Day 1 Pre-Vaccination	4.18 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	TNF-a : Day 29 Post-Vaccination 1	4.88 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP3a : Day 1 Pre-Vaccination	15.34 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	TNF-a : Day 2 Post-Vaccination 1	4.26 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP1b : Day 2 Post-Vaccination 1	16.90 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP1b : Day 29 Post-Vaccination 1	16.05 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP1a : Day 2 Post-Vaccination 1	24.96 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP3a : Day 2 Post-Vaccination 1	13.90 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP1a : Day 4 Post-Vaccination 1	24.44 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP1b : Day 1 Pre-Vaccination	12.99 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	TNF-a : Day 8 Post-Vaccination 2	4.56 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP1a : Day 29 Post-Vaccination 1	26.08 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	TNF-a : Day 2 Post-Vaccination 2	8.13 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP1a : Day 2 Post-Vaccination 2	29.90 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP3a : Day 4 Post-Vaccination 1	16.49 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP1a : Day 4 Post-Vaccination 2	24.08 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP1a : Day 8 Post-Vaccination 2	33.32 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP1a : Day 4 Post-Vaccination 2	23.44 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP1a : Day 8 Post-Vaccination 2	22.54 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP1b : Day 1 Pre-Vaccination	20.33 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP1b : Day 2 Post-Vaccination 1	19.84 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	TNF-a : Day 4 Post-Vaccination 1	5.24 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP1b : Day 4 Post-Vaccination 1	19.16 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	TNF-a : Day 8 Post-Vaccination 2	4.54 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP1b : Day 29 Post-Vaccination 1	18.35 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP1b : Day 2 Post-Vaccination 2	16.78 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP1b : Day 4 Post-Vaccination 2	17.56 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP1b : Day 8 Post-Vaccination 2	16.18 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP3a : Day 1 Pre-Vaccination	16.60 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	TNF-a : Day 29 Post-Vaccination 1	4.93 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP3a : Day 2 Post-Vaccination 1	15.44 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP3a : Day 4 Post-Vaccination 1	15.74 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	TNF-a : Day 2 Post-Vaccination 2	4.78 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP3a : Day 29 Post-Vaccination 1	16.05 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP3a : Day 2 Post-Vaccination 2	14.27 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP3a : Day 4 Post-Vaccination 2	15.31 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP3a : Day 8 Post-Vaccination 2	14.53 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	TNF-a : Day 1 Pre-Vaccination	5.36 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	TNF-a : Day 4 Post-Vaccination 2	5.26 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP1a : Day 1 Pre-Vaccination	22.98 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	TNF-a : Day 2 Post-Vaccination 1	5.40 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP1a : Day 2 Post-Vaccination 1	23.13 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP1a : Day 4 Post-Vaccination 1	22.34 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP1a : Day 29 Post-Vaccination 1	23.09 ng/L
A/H7N9	Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3	MIP1a : Day 2 Post-Vaccination 2	21.25 ng/L

Secondary

Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1

Venous blood samples for plasma were used for this assay. A Luminex assay was used to measure concentrations in ng/L. Concentrations for 7 of the total 24 cytokines and chemokines were measured: Fractalkine, GM-CSF, IP-10, IFNa, IFNb, IFNy, and ITAC. If no cytokine or chemokine measurements were collected, number of participants is reported as 0.

Time frame: Days 2, 4, 8, and 29 Post-Vaccination 1 (Day 2, 4, 8, and 29, respectively); Days 2, 4, and 8 Post-Vaccination 2 (Day 30, 32, and 36, respectively)

Arm	Measure	Group	Value (MEDIAN)
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	GM-CSF : Day 8 Post-Vaccination 1	1.043 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	ITAC : Day 8 Post-Vaccination 1	0.874 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IFNb : Day 4 Post-Vaccination 1	0.941 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	ITAC : Day 2 Post-Vaccination 1	0.975 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IFNb : Day 2 Post-Vaccination 1	0.907 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	ITAC : Day 4 Post-Vaccination 1	1.020 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IFNa : Day 8 Post-Vaccination 1	0.877 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IFNy : Day 8 Post-Vaccination 1	1.018 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IFNa : Day 4 Post-Vaccination 1	0.807 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IP-10 : Day 2 Post-Vaccination 1	0.988 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	Fractalkine : Day 8 Post-Vaccination 1	0.983 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IFNa : Day 2 Post-Vaccination 1	0.830 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IP-10 : Day 4 Post-Vaccination 1	0.983 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IFNy : Day 4 Post-Vaccination 1	1.049 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IP-10 : Day 8 Post-Vaccination 1	0.889 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	GM-CSF : Day 2 Post-Vaccination 1	1.117 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	Fractalkine : Day 4 Post-Vaccination 1	1.024 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IFNy : Day 2 Post-Vaccination 1	0.993 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	GM-CSF : Day 4 Post-Vaccination 1	1.096 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	Fractalkine : Day 2 Post-Vaccination 1	0.944 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IFNb : Day 8 Post-Vaccination 1	1.000 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	ITAC : Day 2 Post-Vaccination 1	1.149 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	Fractalkine : Day 2 Post-Vaccination 1	1.015 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	Fractalkine : Day 4 Post-Vaccination 1	1.092 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	Fractalkine : Day 29 Post-Vaccination 1	0.999 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	Fractalkine : Day 2 Post-Vaccination 2	1.010 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	Fractalkine : Day 4 Post-Vaccination 2	1.022 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	Fractalkine : Day 8 Post-Vaccination 2	0.931 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	GM-CSF : Day 2 Post-Vaccination 1	1.020 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	GM-CSF : Day 4 Post-Vaccination 1	0.932 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	GM-CSF : Day 29 Post-Vaccination 1	1.053 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	GM-CSF : Day 2 Post-Vaccination 2	1.107 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	GM-CSF : Day 4 Post-Vaccination 2	0.832 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	GM-CSF : Day 8 Post-Vaccination 2	1.053 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IP-10 : Day 2 Post-Vaccination 1	1.867 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IP-10 : Day 4 Post-Vaccination 1	1.445 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IP-10 : Day 29 Post-Vaccination 1	0.869 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IP-10 : Day 2 Post-Vaccination 2	4.461 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IP-10 : Day 4 Post-Vaccination 2	1.450 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IP-10 : Day 8 Post-Vaccination 2	1.002 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IFNa : Day 2 Post-Vaccination 1	0.959 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IFNa : Day 4 Post-Vaccination 1	1.023 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IFNa : Day 29 Post-Vaccination 1	0.969 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IFNa : Day 2 Post-Vaccination 2	1.091 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IFNa : Day 4 Post-Vaccination 2	1.079 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IFNa : Day 8 Post-Vaccination 2	1.164 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IFNb : Day 2 Post-Vaccination 1	0.929 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IFNb : Day 4 Post-Vaccination 1	1.134 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IFNb : Day 29 Post-Vaccination 1	0.858 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IFNb : Day 2 Post-Vaccination 2	1.172 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IFNb : Day 4 Post-Vaccination 2	1.051 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IFNb : Day 8 Post-Vaccination 2	1.249 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IFNy : Day 2 Post-Vaccination 1	1.118 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IFNy : Day 4 Post-Vaccination 1	1.018 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IFNy : Day 29 Post-Vaccination 1	1.085 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IFNy : Day 2 Post-Vaccination 2	1.819 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IFNy : Day 4 Post-Vaccination 2	0.854 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IFNy : Day 8 Post-Vaccination 2	0.973 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	ITAC : Day 4 Post-Vaccination 1	1.160 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	ITAC : Day 29 Post-Vaccination 1	0.895 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	ITAC : Day 2 Post-Vaccination 2	2.277 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	ITAC : Day 4 Post-Vaccination 2	1.098 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	ITAC : Day 8 Post-Vaccination 2	1.325 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	GM-CSF : Day 29 Post-Vaccination 1	1.018 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IFNy : Day 8 Post-Vaccination 2	0.927 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IFNb : Day 4 Post-Vaccination 1	1.092 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	GM-CSF : Day 4 Post-Vaccination 1	0.971 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	Fractalkine : Day 2 Post-Vaccination 2	1.053 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IFNb : Day 29 Post-Vaccination 1	0.968 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	Fractalkine : Day 29 Post-Vaccination 1	1.063 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IFNb : Day 2 Post-Vaccination 2	0.989 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	ITAC : Day 2 Post-Vaccination 1	0.926 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IFNb : Day 4 Post-Vaccination 2	1.033 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	Fractalkine : Day 4 Post-Vaccination 1	0.946 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IFNb : Day 8 Post-Vaccination 2	1.074 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	GM-CSF : Day 2 Post-Vaccination 1	0.971 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	ITAC : Day 2 Post-Vaccination 2	0.916 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IFNy : Day 2 Post-Vaccination 1	0.987 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IP-10 : Day 4 Post-Vaccination 1	0.977 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	Fractalkine : Day 8 Post-Vaccination 2	0.985 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IP-10 : Day 29 Post-Vaccination 1	0.868 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	ITAC : Day 4 Post-Vaccination 1	0.953 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IP-10 : Day 2 Post-Vaccination 2	1.097 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IFNy : Day 4 Post-Vaccination 1	0.991 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IP-10 : Day 4 Post-Vaccination 2	1.111 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	Fractalkine : Day 4 Post-Vaccination 2	1.010 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IP-10 : Day 8 Post-Vaccination 2	1.022 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IP-10 : Day 2 Post-Vaccination 1	1.065 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	Fractalkine : Day 2 Post-Vaccination 1	1.003 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IFNa : Day 2 Post-Vaccination 1	1.207 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	GM-CSF : Day 8 Post-Vaccination 2	0.969 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IFNy : Day 29 Post-Vaccination 1	0.958 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IFNa : Day 4 Post-Vaccination 1	1.121 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	GM-CSF : Day 4 Post-Vaccination 2	1.004 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	ITAC : Day 8 Post-Vaccination 2	1.041 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IFNa : Day 29 Post-Vaccination 1	0.924 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IFNy : Day 2 Post-Vaccination 2	0.968 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IFNa : Day 2 Post-Vaccination 2	0.964 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	ITAC : Day 29 Post-Vaccination 1	0.913 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IFNa : Day 4 Post-Vaccination 2	1.252 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IFNy : Day 4 Post-Vaccination 2	0.927 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IFNa : Day 8 Post-Vaccination 2	0.906 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	GM-CSF : Day 2 Post-Vaccination 2	0.994 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	ITAC : Day 4 Post-Vaccination 2	0.852 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1	IFNb : Day 2 Post-Vaccination 1	0.839 fold change

Secondary

Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2

Venous blood samples for plasma were used for this assay. A Luminex assay was used to measure concentrations in ng/L. Concentrations for 17 of the total 24 cytokines and chemokines were measured: IL-1b, IL-10, IL-13, IL-2, IL-21, IL-23, IL-4, IL-5, IL-6, IL-7, IL-8, IL-12p70, IL-17A, MIP1a, MIP1b, MIP3a, and TNF-a. If no cytokine or chemokine measurements were collected, number of participants is reported as 0.

Time frame: Days 2, 4, 8, and 29 Post-Vaccination 1 (Day 2, 4, 8, and 29, respectively); Days 2, 4, and 8 Post-Vaccination 2 (Day 30, 32, and 36, respectively)

Arm	Measure	Group	Value (MEDIAN)
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-2 : Day 8 Post-Vaccination 1	1.080 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	MIP1b : Day 4 Post-Vaccination 1	1.027 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-8 : Day 2 Post-Vaccination 1	1.111 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-10 : Day 8 Post-Vaccination 1	0.979 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-7 : Day 8 Post-Vaccination 1	1.000 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	TNF-a : Day 8 Post-Vaccination 1	0.998 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-7 : Day 4 Post-Vaccination 1	0.952 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	MIP1b : Day 2 Post-Vaccination 1	1.192 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-7 : Day 2 Post-Vaccination 1	1.080 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-21 : Day 2 Post-Vaccination 1	1.152 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	MIP3a : Day 8 Post-Vaccination 1	0.976 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-6 : Day 8 Post-Vaccination 1	0.970 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-21 : Day 4 Post-Vaccination 1	1.402 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	MIP1a : Day 8 Post-Vaccination 1	0.966 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-6 : Day 4 Post-Vaccination 1	1.075 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-21 : Day 8 Post-Vaccination 1	1.149 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	TNF-a : Day 4 Post-Vaccination 1	0.965 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-6 : Day 2 Post-Vaccination 1	1.123 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	MIP1a : Day 4 Post-Vaccination 1	1.089 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-5 : Day 8 Post-Vaccination 1	1.009 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	MIP3a : Day 4 Post-Vaccination 1	1.056 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-5 : Day 4 Post-Vaccination 1	0.986 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	MIP1a : Day 2 Post-Vaccination 1	1.024 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-5 : Day 2 Post-Vaccination 1	1.062 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-23 : Day 2 Post-Vaccination 1	0.907 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-13 : Day 2 Post-Vaccination 1	1.021 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-4 : Day 8 Post-Vaccination 1	0.969 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-23 : Day 4 Post-Vaccination 1	1.014 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-1b : Day 2 Post-Vaccination 1	0.981 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-4 : Day 4 Post-Vaccination 1	1.013 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-23 : Day 8 Post-Vaccination 1	0.930 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-17A : Day 8 Post-Vaccination 1	0.965 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-4 : Day 2 Post-Vaccination 1	0.992 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-13 : Day 4 Post-Vaccination 1	1.059 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-1b : Day 8 Post-Vaccination 1	0.989 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-17A : Day 4 Post-Vaccination 1	1.053 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-13 : Day 8 Post-Vaccination 1	1.065 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	MIP3a : Day 2 Post-Vaccination 1	1.085 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-17A : Day 2 Post-Vaccination 1	1.011 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-10 : Day 2 Post-Vaccination 1	1.106 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-12p70 : Day 8 Post-Vaccination 1	1.012 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-1b : Day 4 Post-Vaccination 1	1.050 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-12p70 : Day 4 Post-Vaccination 1	1.057 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	MIP1b : Day 8 Post-Vaccination 1	1.038 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-12p70 : Day 2 Post-Vaccination 1	1.048 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-2 : Day 2 Post-Vaccination 1	1.055 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-10 : Day 4 Post-Vaccination 1	1.043 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-8 : Day 8 Post-Vaccination 1	1.039 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-2 : Day 4 Post-Vaccination 1	1.020 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	TNF-a : Day 2 Post-Vaccination 1	1.022 fold change
A/H7N9 + AS03	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-8 : Day 4 Post-Vaccination 1	1.073 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-13 : Day 2 Post-Vaccination 1	1.024 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-1b : Day 2 Post-Vaccination 1	0.933 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-1b : Day 4 Post-Vaccination 1	1.004 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-1b : Day 29 Post-Vaccination 1	1.022 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-1b : Day 2 Post-Vaccination 2	0.942 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-1b : Day 4 Post-Vaccination 2	0.890 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-1b : Day 8 Post-Vaccination 2	1.106 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-10 : Day 2 Post-Vaccination 1	1.028 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-10 : Day 4 Post-Vaccination 1	1.118 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-10 : Day 29 Post-Vaccination 1	1.076 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-10 : Day 2 Post-Vaccination 2	1.099 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-10 : Day 4 Post-Vaccination 2	0.950 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-10 : Day 8 Post-Vaccination 2	0.979 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-13 : Day 4 Post-Vaccination 1	0.988 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-13 : Day 29 Post-Vaccination 1	1.074 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-13 : Day 2 Post-Vaccination 2	0.973 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-13 : Day 4 Post-Vaccination 2	0.979 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-13 : Day 8 Post-Vaccination 2	1.013 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-2 : Day 2 Post-Vaccination 1	0.994 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-2 : Day 4 Post-Vaccination 1	1.024 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-2 : Day 29 Post-Vaccination 1	1.119 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-2 : Day 2 Post-Vaccination 2	1.059 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-2 : Day 4 Post-Vaccination 2	0.907 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-2 : Day 8 Post-Vaccination 2	1.031 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-21 : Day 2 Post-Vaccination 1	0.992 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-21 : Day 4 Post-Vaccination 1	0.959 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-21 : Day 29 Post-Vaccination 1	1.213 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-21 : Day 2 Post-Vaccination 2	1.099 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-21 : Day 4 Post-Vaccination 2	0.932 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-21 : Day 8 Post-Vaccination 2	0.861 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-23 : Day 2 Post-Vaccination 1	0.998 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-23 : Day 4 Post-Vaccination 1	1.006 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-23 : Day 29 Post-Vaccination 1	1.041 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-23 : Day 2 Post-Vaccination 2	1.046 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-23 : Day 4 Post-Vaccination 2	1.032 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-23 : Day 8 Post-Vaccination 2	0.954 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-4 : Day 2 Post-Vaccination 1	1.038 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-4 : Day 4 Post-Vaccination 1	1.028 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-4 : Day 29 Post-Vaccination 1	1.038 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-4 : Day 2 Post-Vaccination 2	1.014 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-4 : Day 4 Post-Vaccination 2	0.983 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-4 : Day 8 Post-Vaccination 2	1.083 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-5 : Day 2 Post-Vaccination 1	1.029 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-5 : Day 4 Post-Vaccination 1	1.074 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-5 : Day 29 Post-Vaccination 1	1.010 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-5 : Day 2 Post-Vaccination 2	1.122 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-5 : Day 4 Post-Vaccination 2	1.022 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-5 : Day 8 Post-Vaccination 2	1.123 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-6 : Day 2 Post-Vaccination 1	1.601 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-6 : Day 4 Post-Vaccination 1	0.990 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-6 : Day 29 Post-Vaccination 1	0.921 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-6 : Day 2 Post-Vaccination 2	1.827 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-6 : Day 4 Post-Vaccination 2	0.907 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-6 : Day 8 Post-Vaccination 2	0.921 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-7 : Day 2 Post-Vaccination 1	1.010 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-7 : Day 4 Post-Vaccination 1	1.009 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-7 : Day 29 Post-Vaccination 1	0.969 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-7 : Day 2 Post-Vaccination 2	0.953 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-7 : Day 4 Post-Vaccination 2	0.816 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-7 : Day 8 Post-Vaccination 2	1.262 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-8 : Day 2 Post-Vaccination 1	1.045 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-8 : Day 4 Post-Vaccination 1	0.943 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-8 : Day 29 Post-Vaccination 1	0.970 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-8 : Day 2 Post-Vaccination 2	1.134 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-8 : Day 4 Post-Vaccination 2	0.834 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-8 : Day 8 Post-Vaccination 2	1.299 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-12p70 : Day 2 Post-Vaccination 1	1.029 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-12p70 : Day 4 Post-Vaccination 1	1.029 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-12p70 : Day 29 Post-Vaccination 1	1.052 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-12p70 : Day 2 Post-Vaccination 2	1.026 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-12p70 : Day 4 Post-Vaccination 2	0.933 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-12p70 : Day 8 Post-Vaccination 2	0.901 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-17A : Day 2 Post-Vaccination 1	1.074 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-17A : Day 4 Post-Vaccination 1	1.019 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-17A : Day 29 Post-Vaccination 1	1.153 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-17A : Day 2 Post-Vaccination 2	0.970 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-17A : Day 4 Post-Vaccination 2	0.913 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-17A : Day 8 Post-Vaccination 2	0.891 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	MIP1a : Day 2 Post-Vaccination 1	1.035 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	MIP1a : Day 4 Post-Vaccination 1	1.037 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	MIP1a : Day 29 Post-Vaccination 1	1.049 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	MIP1a : Day 2 Post-Vaccination 2	1.018 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	MIP1a : Day 4 Post-Vaccination 2	0.961 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	MIP1a : Day 8 Post-Vaccination 2	1.097 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	MIP1b : Day 2 Post-Vaccination 1	1.187 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	MIP1b : Day 4 Post-Vaccination 1	1.030 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	MIP1b : Day 29 Post-Vaccination 1	0.958 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	MIP1b : Day 2 Post-Vaccination 2	1.576 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	MIP1b : Day 4 Post-Vaccination 2	0.985 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	MIP1b : Day 8 Post-Vaccination 2	1.194 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	MIP3a : Day 2 Post-Vaccination 1	0.979 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	MIP3a : Day 4 Post-Vaccination 1	0.990 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	MIP3a : Day 29 Post-Vaccination 1	0.945 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	MIP3a : Day 2 Post-Vaccination 2	1.033 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	MIP3a : Day 4 Post-Vaccination 2	1.036 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	MIP3a : Day 8 Post-Vaccination 2	1.055 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	TNF-a : Day 2 Post-Vaccination 1	1.132 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	TNF-a : Day 4 Post-Vaccination 1	1.148 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	TNF-a : Day 29 Post-Vaccination 1	0.977 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	TNF-a : Day 2 Post-Vaccination 2	1.634 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	TNF-a : Day 4 Post-Vaccination 2	1.112 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	TNF-a : Day 8 Post-Vaccination 2	1.199 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-2 : Day 4 Post-Vaccination 1	0.908 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	TNF-a : Day 29 Post-Vaccination 1	0.869 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-8 : Day 4 Post-Vaccination 1	0.944 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-2 : Day 2 Post-Vaccination 1	0.964 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	MIP1b : Day 4 Post-Vaccination 1	1.023 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-8 : Day 29 Post-Vaccination 1	0.914 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-10 : Day 2 Post-Vaccination 1	0.975 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-8 : Day 2 Post-Vaccination 2	0.988 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	MIP3a : Day 8 Post-Vaccination 2	1.076 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-8 : Day 4 Post-Vaccination 2	1.065 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	MIP1b : Day 29 Post-Vaccination 1	0.942 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-8 : Day 8 Post-Vaccination 2	0.966 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-13 : Day 8 Post-Vaccination 2	0.975 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-1b : Day 29 Post-Vaccination 1	0.938 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-12p70 : Day 2 Post-Vaccination 1	0.869 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-13 : Day 4 Post-Vaccination 2	0.976 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	MIP1b : Day 2 Post-Vaccination 2	0.950 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-12p70 : Day 4 Post-Vaccination 1	0.916 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-13 : Day 2 Post-Vaccination 2	0.988 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	TNF-a : Day 4 Post-Vaccination 2	1.047 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-12p70 : Day 29 Post-Vaccination 1	1.059 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	MIP1b : Day 4 Post-Vaccination 2	1.111 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-12p70 : Day 2 Post-Vaccination 2	1.002 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	TNF-a : Day 2 Post-Vaccination 1	0.929 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-12p70 : Day 4 Post-Vaccination 2	1.041 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	MIP1b : Day 8 Post-Vaccination 2	0.960 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-12p70 : Day 8 Post-Vaccination 2	0.936 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-13 : Day 29 Post-Vaccination 1	0.990 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-1b : Day 8 Post-Vaccination 2	0.957 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-17A : Day 2 Post-Vaccination 1	0.932 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-13 : Day 4 Post-Vaccination 1	0.994 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-1b : Day 4 Post-Vaccination 1	0.996 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-17A : Day 4 Post-Vaccination 1	0.911 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-13 : Day 2 Post-Vaccination 1	0.982 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-23 : Day 2 Post-Vaccination 2	0.956 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	MIP3a : Day 2 Post-Vaccination 1	0.968 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-23 : Day 4 Post-Vaccination 2	0.982 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-17A : Day 29 Post-Vaccination 1	0.908 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-23 : Day 8 Post-Vaccination 2	0.979 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-23 : Day 29 Post-Vaccination 1	0.993 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-1b : Day 4 Post-Vaccination 2	1.044 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-4 : Day 2 Post-Vaccination 1	1.034 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-23 : Day 4 Post-Vaccination 1	0.949 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-17A : Day 2 Post-Vaccination 2	0.988 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-4 : Day 4 Post-Vaccination 1	0.921 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-23 : Day 2 Post-Vaccination 1	0.929 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	TNF-a : Day 2 Post-Vaccination 2	1.009 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-4 : Day 29 Post-Vaccination 1	1.014 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-17A : Day 4 Post-Vaccination 2	0.999 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-4 : Day 2 Post-Vaccination 2	0.969 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	MIP3a : Day 4 Post-Vaccination 1	0.976 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-4 : Day 4 Post-Vaccination 2	0.935 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-17A : Day 8 Post-Vaccination 2	0.956 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-4 : Day 8 Post-Vaccination 2	0.910 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-21 : Day 8 Post-Vaccination 2	0.880 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-10 : Day 8 Post-Vaccination 2	0.875 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-5 : Day 2 Post-Vaccination 1	0.978 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-21 : Day 4 Post-Vaccination 2	0.924 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-1b : Day 2 Post-Vaccination 2	0.940 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-5 : Day 4 Post-Vaccination 1	1.037 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-21 : Day 2 Post-Vaccination 2	1.040 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	MIP1a : Day 2 Post-Vaccination 1	0.963 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-5 : Day 29 Post-Vaccination 1	1.040 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-10 : Day 4 Post-Vaccination 2	0.962 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-5 : Day 2 Post-Vaccination 2	0.980 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	TNF-a : Day 4 Post-Vaccination 1	1.070 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-5 : Day 4 Post-Vaccination 2	0.960 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	MIP1a : Day 4 Post-Vaccination 1	0.997 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-5 : Day 8 Post-Vaccination 2	0.965 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-21 : Day 29 Post-Vaccination 1	0.916 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-10 : Day 2 Post-Vaccination 2	0.919 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-6 : Day 2 Post-Vaccination 1	0.952 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-21 : Day 4 Post-Vaccination 1	0.902 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	MIP3a : Day 29 Post-Vaccination 1	0.891 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-6 : Day 4 Post-Vaccination 1	0.969 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-21 : Day 2 Post-Vaccination 1	0.932 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	MIP1a : Day 29 Post-Vaccination 1	1.018 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-6 : Day 29 Post-Vaccination 1	0.996 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-1b : Day 2 Post-Vaccination 1	0.950 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-6 : Day 2 Post-Vaccination 2	0.942 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	MIP1a : Day 2 Post-Vaccination 2	1.008 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-6 : Day 4 Post-Vaccination 2	1.054 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	MIP3a : Day 2 Post-Vaccination 2	0.943 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-6 : Day 8 Post-Vaccination 2	0.961 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-2 : Day 8 Post-Vaccination 2	0.927 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	MIP1a : Day 4 Post-Vaccination 2	0.978 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-7 : Day 2 Post-Vaccination 1	0.982 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-2 : Day 4 Post-Vaccination 2	1.023 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	TNF-a : Day 8 Post-Vaccination 2	0.984 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-7 : Day 4 Post-Vaccination 1	0.934 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-2 : Day 2 Post-Vaccination 2	0.901 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	MIP1a : Day 8 Post-Vaccination 2	0.970 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-7 : Day 29 Post-Vaccination 1	0.976 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-10 : Day 29 Post-Vaccination 1	1.032 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-7 : Day 2 Post-Vaccination 2	0.979 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	MIP3a : Day 4 Post-Vaccination 2	1.021 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-7 : Day 4 Post-Vaccination 2	0.966 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	MIP1b : Day 2 Post-Vaccination 1	0.955 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-7 : Day 8 Post-Vaccination 2	1.022 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-2 : Day 29 Post-Vaccination 1	0.997 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-10 : Day 4 Post-Vaccination 1	1.003 fold change
A/H7N9	Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2	IL-8 : Day 2 Post-Vaccination 1	0.960 fold change

Secondary

Geometric Mean Titers of Serum HAI Antibody (A/H3N2v Vaccine)

Venous blood samples for serum were used for this assay. HAI based on the H3N2 strain A/Minnesota/11/2010 were assessed.

Time frame: Day 1 Pre-Vaccination 1 (Day 1), Day 29 Post-Vaccination 1 (Day 29)

Arm	Measure	Group	Value (GEOMETRIC_MEAN)
A/H7N9 + AS03	Geometric Mean Titers of Serum HAI Antibody (A/H3N2v Vaccine)	Day 1 Pre-Vaccination 1	37.3 titer
A/H7N9 + AS03	Geometric Mean Titers of Serum HAI Antibody (A/H3N2v Vaccine)	Day 29 Post-Vaccination 1	144.2 titer

Secondary

Geometric Mean Titers of Serum HAI Antibody (A/H7N9 Vaccine, With and Without Adjuvant)

Venous blood samples for serum were used for this assay. HAI based on the H7N9 strain A/Shanghai/02/2013xPR8 were assessed.

Time frame: Day 1 Pre-Vaccination 1, Day 29 Post-Vaccination 1 (Day 29), and Day 29 Post-Vaccination 2 (Day 57)

Arm	Measure	Group	Value (GEOMETRIC_MEAN)
A/H7N9 + AS03	Geometric Mean Titers of Serum HAI Antibody (A/H7N9 Vaccine, With and Without Adjuvant)	Day 1 (Pre-Vaccination 1)	5.2 titer
A/H7N9 + AS03	Geometric Mean Titers of Serum HAI Antibody (A/H7N9 Vaccine, With and Without Adjuvant)	Day 29 (Post-Vaccination 1)	7.3 titer
A/H7N9 + AS03	Geometric Mean Titers of Serum HAI Antibody (A/H7N9 Vaccine, With and Without Adjuvant)	Day 29 (Post-Vaccination 2)	85.7 titer
A/H7N9	Geometric Mean Titers of Serum HAI Antibody (A/H7N9 Vaccine, With and Without Adjuvant)	Day 1 (Pre-Vaccination 1)	5.0 titer
A/H7N9	Geometric Mean Titers of Serum HAI Antibody (A/H7N9 Vaccine, With and Without Adjuvant)	Day 29 (Post-Vaccination 1)	5.2 titer
A/H7N9	Geometric Mean Titers of Serum HAI Antibody (A/H7N9 Vaccine, With and Without Adjuvant)	Day 29 (Post-Vaccination 2)	5.0 titer

Secondary

Geometric Mean Titers of Serum Neut Antibody (A/H3N2v Vaccine)

Venous blood samples for serum were used for this assay. Neut based on the H3N2 strain A/Minnesota/11/2010 were assessed.

Time frame: Day 1 Pre-Vaccination 1 (Day 1), Day 29 Post-Vaccination 1 (Day 29)

Arm	Measure	Group	Value (GEOMETRIC_MEAN)
A/H7N9 + AS03	Geometric Mean Titers of Serum Neut Antibody (A/H3N2v Vaccine)	Day 1 Pre-Vaccination 1	171.5 titer
A/H7N9 + AS03	Geometric Mean Titers of Serum Neut Antibody (A/H3N2v Vaccine)	Day 29 Post-Vaccination 1	485.0 titer

Secondary

Geometric Mean Titers of Serum Neut Antibody (A/H7N9 Vaccine, With and Without Adjuvant)

Venous blood samples for serum were used for this assay. Neut based on the H7N9 strain A/Shanghai/02/2013xPR8 were assessed.

Time frame: Day 1 Pre-Vaccination 1 (Day 1), Day 29 Post-Vaccination 1 (Day 29), and Day 29 Post-Vaccination 2 (Day 57)

Arm	Measure	Group	Value (GEOMETRIC_MEAN)
A/H7N9 + AS03	Geometric Mean Titers of Serum Neut Antibody (A/H7N9 Vaccine, With and Without Adjuvant)	Day 1 (Pre-Vaccination 1)	5.0 titer
A/H7N9 + AS03	Geometric Mean Titers of Serum Neut Antibody (A/H7N9 Vaccine, With and Without Adjuvant)	Day 29 (Post-Vaccination 1)	17.4 titer
A/H7N9 + AS03	Geometric Mean Titers of Serum Neut Antibody (A/H7N9 Vaccine, With and Without Adjuvant)	Day 29 (Post-Vaccination 2)	190.3 titer
A/H7N9	Geometric Mean Titers of Serum Neut Antibody (A/H7N9 Vaccine, With and Without Adjuvant)	Day 1 (Pre-Vaccination 1)	5.0 titer
A/H7N9	Geometric Mean Titers of Serum Neut Antibody (A/H7N9 Vaccine, With and Without Adjuvant)	Day 29 (Post-Vaccination 1)	5.4 titer
A/H7N9	Geometric Mean Titers of Serum Neut Antibody (A/H7N9 Vaccine, With and Without Adjuvant)	Day 29 (Post-Vaccination 2)	5.9 titer

Secondary

Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H3N2v Vaccine)

RNA expression levels (read counts) for each gene were determined by RNA-Sequencing of RNA extracted from six separated cell types: monocytes, dendritic cells, neutrophils, NK cells, B cells, and T cells. Post-vaccination gene expression levels were compared to pre-vaccination gene expression levels (combined summed read counts for Day -7 and Day 1 samples for post-vaccination 1 timepoints) using a negative binomial model to identify differentially expressed (DE) genes (FDR-adjusted p-value \< 0.05 and mean fold change =\> 1.5 in either direction).

Time frame: Days 2, 4, and 8 Post-Vaccination 1 (Day 2, 4, and 8, respectively)

Population: The transcriptomics analysis population A/H3N2v arm: Includes all participants in the A/H3N2v arm who received at least one study vaccination and contributed at least one pre- and one post vaccination sample for transcriptomics testing for which valid results were reported.

Arm	Measure	Group	Value (NUMBER)
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H3N2v Vaccine)	Monocytes : Day 2 Post Vaccination 1	0 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H3N2v Vaccine)	Monocytes : Day 4 Post Vaccination 1	0 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H3N2v Vaccine)	Monocytes : Day 8 Post Vaccination 1	1 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H3N2v Vaccine)	Dendritic cells : Day 2 Post Vaccination 1	0 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H3N2v Vaccine)	Dendritic cells : Day 4 Post Vaccination 1	0 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H3N2v Vaccine)	Dendritic cells : Day 8 Post Vaccination 1	2 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H3N2v Vaccine)	Neutrophils : Day 2 Post Vaccination 1	0 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H3N2v Vaccine)	Neutrophils : Day 4 Post Vaccination 1	0 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H3N2v Vaccine)	Neutrophils : Day 8 Post Vaccination 1	41 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H3N2v Vaccine)	NK cells : Day 2 Post Vaccination 1	0 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H3N2v Vaccine)	NK cells : Day 4 Post Vaccination 1	0 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H3N2v Vaccine)	NK cells : Day 8 Post Vaccination 1	1 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H3N2v Vaccine)	B cells : Day 2 Post Vaccination 1	0 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H3N2v Vaccine)	B cells : Day 4 Post Vaccination 1	0 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H3N2v Vaccine)	B cells : Day 8 Post Vaccination 1	3 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H3N2v Vaccine)	T cells : Day 2 Post Vaccination 1	0 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H3N2v Vaccine)	T cells : Day 4 Post Vaccination 1	0 Number of DE genes
A/H7N9 + AS03	Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H3N2v Vaccine)	T cells : Day 8 Post Vaccination 1	0 Number of DE genes

Secondary

Percentage of Participants Achieving Seroconversion Based on Neut Titer (A/H3N2v Vaccine)

Seroconversion is defined as either a pre-vaccination Neut titer \<1:10 and a post-vaccination Neut titer =\>1:40 or a pre-vaccination Neut titer =\>1:10 and a minimum four-fold rise in post-vaccination Neut titer. Venous blood samples for serum were used for this assay. Neut based on the H3N2 strain A/Minnesota/11/2010 were assessed.

Time frame: Day 29 Post-Vaccination 1 (Day 29)

Arm	Measure	Value (NUMBER)
A/H7N9 + AS03	Percentage of Participants Achieving Seroconversion Based on Neut Titer (A/H3N2v Vaccine)	40 percentage of participants

Secondary

Percentage of Participants Achieving Seroconversion Based on Neut Titer (A/H7N9 Vaccine, With and Without Adjuvant)

Time frame: Day 29 Post-Vaccination 2 (Day 57)

Arm	Measure	Value (NUMBER)
A/H7N9 + AS03	Percentage of Participants Achieving Seroconversion Based on Neut Titer (A/H7N9 Vaccine, With and Without Adjuvant)	100 percentage of participants
A/H7N9	Percentage of Participants Achieving Seroconversion Based on Neut Titer (A/H7N9 Vaccine, With and Without Adjuvant)	0 percentage of participants

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026

H7N9 Vaccination With and Without AS03 and Unadjuvanted H3N2v Vaccination: Standard and Systems Biology Analyses

Conditions

Keywords

Brief summary

Detailed description

Related papers

Interventions

Sponsors

Study design

Eligibility

Inclusion criteria

Exclusion criteria

Design outcomes

Primary

Secondary

Countries

Participant flow

Recruitment details

Participants by arm

Baseline characteristics

Adverse events

Outcome results

Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H7N9 Vaccine, With and Without Adjuvant)

Percentage of Participants Achieving Seroconversion Based on HAI Titer (A/H3N2v Vaccine)

Percentage of Participants Achieving Seroconversion Based on HAI Titer (A/H7N9 Vaccine, With and Without Adjuvant)

Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 1

Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 2

Cytokine and Chemokine Concentration by Study Arm and Study Visit Day - Part 3

Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 1

Fold Change in Cytokine and Chemokine Concentrations From Pre-vaccination - Part 2

Geometric Mean Titers of Serum HAI Antibody (A/H3N2v Vaccine)

Geometric Mean Titers of Serum HAI Antibody (A/H7N9 Vaccine, With and Without Adjuvant)

Geometric Mean Titers of Serum Neut Antibody (A/H3N2v Vaccine)

Geometric Mean Titers of Serum Neut Antibody (A/H7N9 Vaccine, With and Without Adjuvant)

Number of Differentially Expressed Genes Based on RNA Expression in Human Immune Cells (A/H3N2v Vaccine)

Percentage of Participants Achieving Seroconversion Based on Neut Titer (A/H3N2v Vaccine)

Percentage of Participants Achieving Seroconversion Based on Neut Titer (A/H7N9 Vaccine, With and Without Adjuvant)