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AS03

DRUG12 trials

Sponsors

National Institute of Allergy and Infectious Diseases (NIAID), Biomedical Advanced Research and Development Authority

Conditions

Avian InfluenzaCOVID-19H1N1 InfluenzaInfluenzaInfluenza ImmunisationInfluenza, Human

Phase 1

H5N8 Mix and Match With or Without AS03 or MF59 in Healthy Adults
CompletedNCT02624219
National Institute of Allergy and Infectious Diseases (NIAID)Avian Influenza, Influenza
Start: 2016-08-16End: 2018-01-30Updated: 2019-10-23
H5N8 Mix and Match With or Without AS03 or MF59 in Healthy Adults: Immunology
CompletedNCT03014310
National Institute of Allergy and Infectious Diseases (NIAID)Avian Influenza
Start: 2017-01-09End: 2018-12-19Updated: 2024-09-23

Phase 2

Sanofi H1N1 Influenza Vaccine Administered at Different Dose Levels With and Without AS03 Adjuvant in Healthy Adult and Elderly Populations
CompletedNCT00963157
National Institute of Allergy and Infectious Diseases (NIAID)Influenza
Start: 2009-09-30End: 2010-12-31Updated: 2014-12-24
CSL H1N1 Influenza Vaccine Administered at Different Dose Levels With and Without AS03 Adjuvant in Healthy Adult and Elderly Populations
WithdrawnNCT00964951
National Institute of Allergy and Infectious Diseases (NIAID)Influenza
End: 2010-11-30Updated: 2018-10-16
H7N9 Mix and Match With AS03 and MF59 in Healthy Adults
CompletedNCT01942265
National Institute of Allergy and Infectious Diseases (NIAID)Influenza
Start: 2013-09-30End: 2015-01-31Updated: 2017-07-06
H7N9 Vaccination With and Without AS03 and Unadjuvanted H3N2v Vaccination: Standard and Systems Biology Analyses
CompletedNCT02921997
National Institute of Allergy and Infectious Diseases (NIAID)Avian Influenza, H1N1 Influenza, Influenza
Start: 2016-11-07End: 2018-02-14Updated: 2024-10-09
Panblok H7 Vaccine Adjuvanted With AS03 or MF59
CompletedNCT03283319
Biomedical Advanced Research and Development AuthorityInfluenza, Human
Start: 2017-09-20End: 2018-11-09Updated: 2020-05-06
Sanofi 2017 H7N9 With/Without AS03 in Adults/Elderly
CompletedNCT03312231
National Institute of Allergy and Infectious Diseases (NIAID)Avian Influenza, Influenza Immunisation
Start: 2018-02-14End: 2019-09-26Updated: 2024-09-19
Co-Administration of AS03 Adjuvanted A/H7N9 IIV With IIV4
CompletedNCT03318315
National Institute of Allergy and Infectious Diseases (NIAID)Avian Influenza, Influenza, Influenza Immunisation
Start: 2018-02-20End: 2019-07-25Updated: 2020-08-06
2013/2017 H7N9 Prime-Boost Interval
CompletedNCT03589807
National Institute of Allergy and Infectious Diseases (NIAID)Avian Influenza, Influenza Immunisation
Start: 2018-08-21End: 2020-06-14Updated: 2021-08-02
2017 A/H7N9 IIV Revaccination
CompletedNCT03738241
National Institute of Allergy and Infectious Diseases (NIAID)Avian Influenza, Influenza Immunisation
Start: 2018-12-18End: 2020-06-19Updated: 2021-07-30
COVID-19 Variant Immunologic Landscape Trial (COVAIL Trial)
CompletedNCT05289037
National Institute of Allergy and Infectious Diseases (NIAID)COVID-19
Start: 2022-03-30End: 2023-11-27Updated: 2025-10-17

Related Papers

Effect of Omicron BA.1-based compared to prototype booster mRNA vaccination on incidence of COVID-19 in the COVAIL trial
Vaccine2025-09-09
Neutralizing antibody immune correlates in COVAIL trial recipients of an mRNA second COVID-19 vaccine boost.
2025-01-177 citations
Anti-neuraminidase and anti-hemagglutinin stalk responses to different influenza a(H7N9) vaccine regimens.
2025-01-042 citations
Immunogenicity and Safety of AS03‐Adjuvanted H7N9 Influenza Vaccine in Adults (18–64 and ≥65 Years): A Phase 1/2, Randomized, Placebo‐Controlled Trial
Influenza and Other Respiratory Viruses2024-12-01
A Phase 2 Clinical Trial to Evaluate the Safety, Reactogenicity, and Immunogenicity of Different Prime-Boost Vaccination Schedules of 2013 and 2017 A(H7N9) Inactivated Influenza Virus Vaccines Administered With and Without AS03 Adjuvant in Healthy US Adults
Clinical Infectious Diseases2024-03-278 citations
Comparison of bivalent and monovalent SARS-CoV-2 variant vaccines: the phase 2 randomized open-label COVAIL trial.
2023-08-2839 citations
Safety and Immunogenicity of a Delayed Heterologous Avian Influenza A(H7N9) Vaccine Boost Following Different Priming Regimens: A Randomized Clinical Trial
The Journal of Infectious Diseases2023-07-197 citations
Safety and immunogenicity of monovalent H7N9 influenza vaccine with AS03 adjuvant given sequentially or simultaneously with a seasonal influenza vaccine: A randomized clinical trial.
2022-04-227 citations
A Phase 1 Randomized Placebo-Controlled Study to Assess the Safety, Immunogenicity and Genetic Stability of a New Potential Pandemic H7N9 Live Attenuated Influenza Vaccine in Healthy Adults
Vaccines2020-06-107 citations
Effect of Varying Doses of a Monovalent H7N9 Influenza Vaccine With and Without AS03 and MF59 Adjuvants on Immune Response
JAMA2015-07-21138 citations
Immunogenicity and safety of varying dosages of a monovalent 2009 H1N1 influenza vaccine given with and without AS03 adjuvant system in healthy adults and older persons.
2012-07-1036 citations