Kidney Transplantation
Conditions
Brief summary
The objective of the study is to evaluate the effect of iguratimod concomitant with conventional immunosuppressive drugs on preventing antibody-induced rejection in HLA Highly mismatched Kidney Transplant recipients.
Interventions
DRUGIguratimod
Subjects will receive iguratimod orally, twice a day, for consecutive 52 weeks
DRUGMycophenolate mofetil
All subjects will receive mycophenolate mofetil for consecutive 52 weeks
DRUGTacrolimus
All subjects will receive tacrolimus for consecutive 52 weeks
DRUGGlucocorticoids
All subjects will receive glucocorticoids for consecutive 52 weeks
Sponsors
The First Affiliated Hospital with Nanjing Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Male or female, aged ≥18, \<65 years * At least 2 weeks post kidney transplantation from deceased or living donor * Stable renal graft function, i.e., serum creatinine undulation for 3 consecutive test \<±10% * Serum creatinine\<1.5×upper limits of normal(ULN) * Number of HLA mismatches ≥ 4 * Panel Reactive Antibody(PRA) value pre-transplantation \<10% * Concentration of conventional immunosuppressive drugs reach target ranges * Subjects are willing to participate in the study, fully informed, and sign informed consent form(ICF) * Women of childbearing potential (WOCBP) must have a negative pregnancy test within 24 hours prior to the start of study medication, and agree to use an acceptable method to avoid pregnancy for the entire study period and for up to 3 months after the last dose of study medication.
Exclusion criteria
* Pregnant or nursing women * Currently clinical acute rejection; * Graft function hasn't recovered for delayed graft function (DGF), or primary non-function (PNF) * Second or subsequent kidney transplant or multi-organ recipients (e.g. kidney and pancreas) * Subjects with Liver failure * Abnormal hepatic, renal and hematopoietic function, 1. Alanine transaminase(ALT), Aspartate transaminase(AST)\>1.5×ULN 2. White blood cell(WBC)\<3.5×10\^9/L 3. Hemoglobin(HGB)\<80 g/L 4. Platelet count(PLT)\<80×10\^9/L. * Severe clinically relevant disease, 1. Abnormality in chest X ray image, such as Tuberculosis, Pulmonary interstitial fibrosis, or symptom or physical sign of clinical significance 2. Serious cardiovascular, hepatic, hematological, endocrinal disease, or malignancy 3）History of serious cardiovascular, hepatic, hematological, endocrinal disease, or malignancy 4\) Immunodeficiency, uncontrolled active infection, and active gastrointestinal disease. * Women or men of childbearing potential plan to be pregnant recently; * Allergic with study drug, or excipient * Subject with psychiatric illness, which may put him/her into unacceptable risk in the opinion of investigators * Has received or is receiving Rituximab treatment * Iguratimod treatment within 1 week pre-transplantation, or during screening period * Received live vaccines in the previous 3 months, or plan to receive live vaccines during the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Biopsy-proven acute rejection rates | 0-52 week |
| Survival of transplanted kidney | 52 week |
Secondary
| Measure | Time frame |
|---|---|
| Donor Specific Antibody(DSA) level compared to baseline | 52 week |
| Graft renal function | 52 week |
| Adverse event | 0-52 week |
Countries
China
Contacts
Primary ContactHao Chen
Outcome results
None listed