Iguratimod

DRUG20 trials

Sponsors

Jiangsu Simcere Pharmaceutical Co., Ltd., Eisai Co., Ltd., The First Affiliated Hospital with Nanjing Medical University, RenJi Hospital, Peking Union Medical College Hospital

Conditions

Arthritis, RheumatoidHand OsteoarthritisITPImmune ThrombocytopeniaImmune Thrombocytopenia (ITP)Inflammatory ArthritisKidney TransplantationLupus Nephritis

Phase 1

Study of Iguratimod in Sjögren's Syndrome

Peking Union Medical College HospitalSjogren's Syndrome

Start: 2017-02-28End: 2018-04-30Target: 30Updated: 2017-01-18

Phase 2

The Iguratimod Effect on Lupus Nephritis (IGeLU)

RenJi HospitalLupus Nephritis

Start: 2017-09-07End: 2021-11-30Target: 120Updated: 2018-12-19

A Study to Evaluate the Efficacy and Safety of Iguratimod Compared to Placebo in Patients With Active Primary Sjogren's Syndrome.

Jiangsu Simcere Pharmaceutical Co., Ltd.Primary Sjögren Syndrome

Start: 2021-03-22End: 2022-06-30Target: 144Updated: 2021-07-19

Efficacy and Safety of Iguratimod in Patients With Hand Osteoarthritis (ESIGO)

Peking University People's HospitalHand Osteoarthritis, Inflammatory Arthritis

Start: 2022-03-31End: 2024-12-31Target: 150Updated: 2022-02-08

The Combination of Iguratimod and Danazol as the Treatment of Steroid-resistant/Relapse Immune Thrombocytopenia

Peking University People's HospitalImmune Thrombocytopenia, ITP

Start: 2021-09-01End: 2023-12-30Target: 120Updated: 2022-05-02

Efficacy and Safety of Iguratimod in the Treatment of Steroid-resistant/Relapse Immune Thrombocytopenia

Peking University People's HospitalImmune Thrombocytopenia

Start: 2022-03-22End: 2023-12-12Target: 100Updated: 2022-03-31

Iguratimod Plus Low-dose Rituximab vs Low-dose Rituximab in Corticosteroid-resistant or Relapsed ITP

Not yet recruitingNCT07057778

Peking University People's HospitalImmune Thrombocytopenia (ITP)

Start: 2025-07-01End: 2027-07-01Target: 120Updated: 2025-07-10

Phase 3

Safety and Efficacy of Iguratimod in the Treatment of Chronic GVHD

RecruitingNCT06244628

Xuzhou Medical UniversitycGVHD

Start: 2024-01-10End: 2028-12-31Target: 20Updated: 2026-05-27

Phase 4

Long-term Efficacy of Iguratimod Alone or Iguratimod in Combination With Methotrexate in Patients With Rheumatoid Arthritis

Jiangsu Simcere Pharmaceutical Co., Ltd.Rheumatoid Arthritis

Start: 2012-05-31End: 2017-01-31Updated: 2016-02-23

A Study of Iguratimod in Patients With Active Rheumatoid Arthritis

CompletedNCT01554917

Jiangsu Simcere Pharmaceutical Co., Ltd.Rheumatoid Arthritis

Start: 2012-05-31End: 2015-08-31Updated: 2020-10-14

Effectiveness of Iguratimod Versus Placebo to Treat Early Rheumatoid Arthritis on MRI

Jiangsu Simcere Pharmaceutical Co., Ltd.Rheumatoid Arthritis

Start: 2012-07-31End: 2015-12-31Target: 200Updated: 2014-10-23

Study of Iguratimod Plus Methotrexate Compared to Leflunomid Plus Methotrexate in Patients With Rheumatoid Arthritis

Jiangsu Simcere Pharmaceutical Co., Ltd.Rheumatoid Arthritis

Start: 2013-09-30End: 2016-02-29Target: 240Updated: 2014-10-27

The Clinical Efficacy and Safety of Iguratimod in RA and Early RA Patients for 6 Months Treatment

CompletedNCT03855007

Qilu Hospital of Shandong UniversityArthritis, Rheumatoid

Start: 2016-01-01End: 2023-10-31Updated: 2023-11-18

The Efficacy and Safety of Tofacitinib (TF) With Iguratimod (IGU) on RA

CompletedNCT04928066

Qilu Hospital of Shandong UniversityArthritis, Rheumatoid

Start: 2020-03-01End: 2023-07-30Updated: 2023-11-18

The Clinical Efficacy of Immunomodulators in RA Patients

RecruitingNCT05626348

Qilu Hospital of Shandong UniversityArthritis, Rheumatoid

Start: 2021-12-22End: 2026-12-31Target: 400Updated: 2022-11-29

Efficacy Study of Iguratimod Combined With Tofacitab in Patients With RF Positive/Negative Rheumatoid Arthritis

RecruitingNCT06146972

Yanfeng HouRheumatoid Arthritis, Therapy

Start: 2021-06-01End: 2024-05-31Target: 117Updated: 2024-03-25

Unknown Phase

Investigation of the Safety and Efficacy of Iguratimod in Patients With Rheumatoid Arthritis

CompletedNCT01850966

Eisai Co., Ltd.Rheumatoid Arthritis

Start: 2012-09-12End: 2014-04-13Updated: 2018-11-05

Iguratimod in Kidney Transplant Recipients

The First Affiliated Hospital with Nanjing Medical UniversityKidney Transplantation

Start: 2016-08-31End: 2019-07-31Target: 60Updated: 2018-08-29

Iguratimod as Treatment for Refractory Lupus Nephritis

RenJi HospitalLupus Nephritis

Start: 2017-05-08End: 2019-04-30Target: 30Updated: 2017-02-27

Iguratimod in Systemic Sclerosis

RenJi HospitalSystemic Sclerosis, Diffuse

Start: 2021-01-01End: 2024-01-31Target: 20Updated: 2020-08-17

Related Papers

Iguratimod plus low-dose rituximab as second-line treatment in adults with primary immune thrombocytopenia: A multicenter, open-label, randomized, controlled, Phase 2 trial

Blood2025-11-03

The SMILE study: Study of long-term methotrexate and iguratimod combination therapy in early rheumatoid arthritis

Chinese Medical Journal2024-07-263 citations

The Combination of Iguratimod and Danazol Versus Danazol As a Treatment of Corticosteroid-Resistant/Relapse Immune Thrombocytopenia: A Randomized, Controlled, Multicenter, Open-Label Trial

Blood2023-11-02

Efficacy of iguratimod on mineral and bone disorders after kidney transplantation: a preliminary study.

2023-10-312 citations

Comparison of iguratimod and conventional cyclophosphamide with sequential azathioprine as treatment of active lupus nephritis: study protocol for a multi-center, randomized, controlled clinical trial (iGeLU study).

2021-08-116 citations

Effectiveness and safety of iguratimod treatment in patients with active rheumatoid arthritis in Chinese: A nationwide, prospective real-world study.

2021-03-2211 citations