Impaired Glucose Tolerance
Conditions
Brief summary
This study will determine the influence of two non-caloric sweeteners on glucose metabolism via the gut microbiome in adult men and women.
Detailed description
This study will determine the influence of two non-caloric sweeteners on glucose metabolism via the gut microbiome in adult men and women aged 35-55 years.
Interventions
OTHERSucralose
Sweetner
OTHERStevia
Sweetner
Sponsors
University of Minnesota
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
35 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
Generally health adult men and women aged 35-55 years old -
Exclusion criteria
Adults will not be eligible who have chronic disease (cancer, CHD, diabetes, chronic kidney disease); pregnant or breast feeding; menopausal; has a history of bariatric surgery; taking prednisone/steroids, taking medication for PCOS, or take medications that influence blood glucose. \-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 2-hour glucose | 14 days | An oral glucose tolerance test will be administered before and after consuming assigned sweetener to determine change in 2-hour glucose |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Gut microbiome | 14 days | Gut microbiota will be measured before and after consuming assigned sweetener to determine change in gut microbiota. |
Countries
United States
Outcome results
None listed