Metabolic Syndrome
Conditions
Brief summary
Metabolic syndrome (Mets) is an assemblage of risk factors which can increase the risk of developing type 2 diabetes mellitus and cardiovascular disease. Green coffee extract (GCE) is derived from unroasted coffee beans and has substantial amounts of polyphenols primarily chlorogenic acids (CGA). It has been shown that GCE and CGA can exert a positive influence over Mets components including blood pressure, blood glucose, inflammation, oxidative stress, insulin resistance and blood lipids. Up to our knowledge no study has been conducted on humans in the field of GCA influences on Mets patients. Therefore, this study is planned to evaluate GCA supplementation effects on anthropometric measurements, glycemic control, blood pressure, lipid profile in patients with metabolic syndrome.
Interventions
DIETARY_SUPPLEMENTgreen coffee extract
DIETARY_SUPPLEMENTplacebo
Sponsors
National Nutrition and Food Technology Institute
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Waist circumference\>102 cm in men and \>88 cm in women * Fasting blood glucose\>100 mg/dL (5.6 mmol /L) * Systolic blood pressure\>130 mmHg or diastolic blood pressure\>85mmHg * Triglycerides\> 150 mg/dL (1.7 mmol/L)
Exclusion criteria
* Insulin administration * Pregnancy and breastfeeding * regular consumption of coffee and green tea
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| fasting blood glucose | 8 weeks |
Secondary
| Measure | Time frame |
|---|---|
| HOMA-IR | 8 weeks |
| blood pressure | 8 weeks |
| insulin | 8 weeks |
| hemoglubin A1c | 8 weeks |
| triglyceride | 8 weeks |
Countries
Iran
Outcome results
None listed