Postprandial Hyperglycemia
Conditions
Keywords
Xylose, prediabetes, postprandial hyperglycemia, glucose
Brief summary
The present study determined the effect of Xylose consumption on postprandial hyperglycemia in normal (n=25) and hyperglycemic subjects (n=50).
Detailed description
In this double-blind crossover designed study, Participants were randomly assigned to consume a sucrose drink (Control, sucrose 50g + deionized water 100g) or a sucrose drink additionally containing 5 g (Test 1, sucrose : xylose = 10:1), 3.33 g (Test 2, sucrose : xylose = 15:1) or 2.5 g (Test 3, sucrose : xylose = 20:1) of D-xylose with a week interval.
Interventions
DIETARY_SUPPLEMENTTest 1
sucrose : xylose = 10:1, sucrose 50 g + xylose 5 g + deionized water 95 g
DIETARY_SUPPLEMENTTest 2
sucrose : xylose = 15:1, sucrose 50 g + xylose 3.33 g + deionized water 96.67 g
DIETARY_SUPPLEMENTTest 3
sucrose : xylose = 20:1, sucrose 50 g + xylose 2.5 g + deionized water 97.5 g
DIETARY_SUPPLEMENTControl
sucrose 50 g + deionized water 100 g
Sponsors
Yonsei University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
20 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
1\) healthy subject or Impaired fasting glucose (fasting serum glucose between 100 and 125 mg/dL)
Exclusion criteria
1. history of taking an insulin-injection or oral hypoglycemic agents 2. evidence of alcohol abuse or alcoholism 3. pregnancy or breast feeding 4. chronic gastrointestinal disorder 5. seriously abnormal liver or renal function 6. an occupation at risk of death when hypoglycemia occurs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change of serum glucose levels | a week interval |
Secondary
| Measure | Time frame |
|---|---|
| Change of serum insulin levels | a week interval |
| Change of serum C-peptide levels | a week interval |
Outcome results
None listed