Persistent Atrial Fibrillation
Conditions
Brief summary
Atrial fibrillation (AF) is associated with impaired cognitive function (CogF) and/or dementia, but it is unclear whether rhythm control of AF improves CogF or brain perfusion. The hypothesis is rhythm control of AF improves CogF by increasing brain perfusion with hemodynamic amelioration compared to AF state. We will randomize the patients with persistent AF to rhythm control group and rate control group, and check baseline and 3rd month cognitive function (K-MOCA score) and brain perfusion CT. K-MOCA score and brain perfusion CT findings will be compared between rhythm control group and rate control group of persistent AF.
Interventions
DRUGPropafenone
AAD(antiarrhythmic drug)
DRUGApixaban
anti-coagulation
Sponsors
Yonsei University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Patients with persistent Atrial fibrillation (20\ 80 years old) * LA diameter \< 55mm * patients possible to anticoagulation and anti arrhythmic drug
Exclusion criteria
* Structural cardiac disease * Contraindication to brain perfusion CT * Catheter ablation history for AF, Cardiac surgery * active internal bleeding * Impossible to anticoagulation or antiarrhythmic drug * valvular AF ((MA\> GII, Mechanical valve, Mitral valve replacement) * LVEF \< 30% * With severe medical disease * Expected survival \< 1 year * Severe alcoholics, drug addiction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| K-MOCA(Korean version of Montreal Cognitive Assessment) | 12 months after the enrollment |
| Brain perfusion CT | 12 months after the enrollment |
Countries
South Korea
Contacts
Primary ContactHui-Nam Park, MD, Ph.D
Outcome results
None listed