Morbid Obesity
Conditions
Keywords
General anaesthesia, Curarization with rocuronium
Brief summary
This randomized double blind clinical trial focuses on patients with Body Masse Index ≥ 40 kg/m2, undergoing scheduled surgery. Neuromuscular transmission monitoring at the adductor is performed using. Anaesthesia is induced with anaesthesic and maintained with curare. At the end of the procedure, patients with profound neuromuscular blockade receive either 1 mg/kg, 2 mg/kg or 4 mg/kg Sugammadex based on ideal body weight. A complete reversal failure is defined by a Train Of Four ratio \< 0.9 within 10 min after administration of Sugammadex or if recurarization occurs within 15 min after complete reversal success.
Interventions
Sponsors
Poitiers University Hospital
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* General anaesthesia * Neuromuscular blockade induce by rocuronium * Body Masse Indice ≥ 40 kg/m2 * informed consent
Exclusion criteria
* Contraindication to rocuronium or sugammadex * Pregnant women * Severe renal insufficiency
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| determine a profound neuromuscular blockade reversal on ideal body weight | 30 minutes | A complete reversal failure is defined by a Train Of Four ratio \< 0.9 within 10 min after administration of Sugammadex or if recurarization occurs within 15 min after complete reversal success |
Secondary
| Measure | Time frame |
|---|---|
| Compare dosages based on ideal body weight to real body weight | 30 minutes |
Countries
France
Outcome results
None listed