Postoperative Pain, Postoperative Vomiting
Conditions
Keywords
dexmedetomidine, subtenon anesthesia, postoperative pain, pov
Brief summary
The purpose of the present study was to evaluate the efficacy and safety of subtenon block (SB)anesthesia with dexmedetomidine in combination with bupivacaine versus intravenous dexmedetomidine for postoperative analgesia and emesis control in infants undergoing cataract surgery.
Detailed description
In this prospective, randomized, controlled, double blind trial eighty ASA physical status grade I and II infants (1-12month) undergoing elective cataract surgery in one eye under general anesthesia were studied. Infants were randomly allocated to one of the two groups: subtenon block Group (SB) with dexmedetomidine (n =40) or intravenous dexmedetomidine Group (IV) (n =40). After securing the airway, infants in Group (SB) received SB block with 0.05 mL/kg of 0.5%bupivacaine and 0.5µ/kg dexmedetomidine mixture, whereas infants in Group (IV) received 1µ/kg IV dexmedetomidine after induction of anesthesia. Surgery started after 5 min of study drug administration. Postoperative assessment for number of infants requiring rescue analgesia and rescue antiemetics was the primary outcome. CRIES pain scale score , vomiting scale score during4-h study period, incidence of oculocardiac reflex and any surgical difficulty were the Secondary outcomes.
Interventions
DRUGSB dexmedetomidine bupivacaine block
SB block with 0.05 mL/kg of 0.5%bupivacaine and 0.5µ/kg dexmedetomidine mixture
received 1µ/kg IV dexmedetomidine
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
1 Months to 12 Months
Healthy volunteers
No
Inclusion criteria
1. ASA physical status grade I and II infants (1-12month). 2. undergoing elective cataract surgery in one eye under general anesthesia.
Exclusion criteria
1. infection of the orbit, 2. increased intraocular pressure(IOP), 3. history of allergy to local anesthetics, 4. history of previous eye surgery, 5. cardiovascular or clotting disorders, 6. full stomach,inner ear disorders or other conditions predisposing to vomiting 7. airway abnormalities 8. compromised sclera.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative assessment for number of infants requiring rescue analgesia and rescue antiemetics | 4 hours postoperatively | by analysis for number of infants withCRIES pain scale score \>3 |
| postoperative CRIES pain scale score | 4 hours postoperatively | (0-2 for each parameter) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| vomiting scale score | 4 hours postoperative | a numeric rank score, where 0= no vomiting 1=vomited once and 2=vomited twice or more |
| Number of oculocardiac reflex(OCR)events(acute reduction in heart rate of >20%). | intraoperative period | by analysis |
Countries
Egypt
Contacts
Primary Contactjehan A sayed, MD
Outcome results
None listed