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Does Sourdough Fermentation Improve Iron Uptake From Whole Grain Rye Bread?

Does Sourdough Fermentation Improve Iron Uptake From Whole Grain Rye Bread?

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02462798
Enrollment
102
Registered
2015-06-04
Start date
2010-01-31
Completion date
2015-12-31
Last updated
2018-03-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anaemia, Iron Bioavailability

Brief summary

Iron deficiency anaemia is a major problem for women worldwide. Cereal foods are a major source of iron, but much of this is not bioavailability due to it being bound by the high amounts of phytate present in cereals. Destruction of phytate by the phytase enzyme can release iron and increase its bioavailability. In a human cell model of iron uptake, sourdough fermentation, which included activation of phytase, the enzyme that breaks down phyate, led to improved iron bioavailability. This clinical trial will attempt to demonstrate that this concept also works in humans

Interventions

Whole grain rye bread baked without sourdough fermentation (normal yeast-based fermentation)

OTHERWhole grain sourdough rye bread

Whole grain rye bread fermented with sourdough culture before baking

Sponsors

Sahlgrenska University Hospital
CollaboratorOTHER
Chalmers University of Technology
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
FEMALE
Age
18 Years to 50 Years
Healthy volunteers
Yes

Inclusion criteria

* Healthy women under 50 years old

Exclusion criteria

* Pregnancy or breast feeding * Use of mineral or other dietary supplements * Use of medical or recreational drugs * Donation of blood within the previous 3 months

Design outcomes

Primary

MeasureTime frame
Serum ferritin12 week values corrected for baseline
Serum transferrin receptor12 week values corrected for baseline
Haemoglobin12 week values corrected for baseline

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026