Anaemia, Iron Bioavailability
Conditions
Brief summary
Iron deficiency anaemia is a major problem for women worldwide. Cereal foods are a major source of iron, but much of this is not bioavailability due to it being bound by the high amounts of phytate present in cereals. Destruction of phytate by the phytase enzyme can release iron and increase its bioavailability. In a human cell model of iron uptake, sourdough fermentation, which included activation of phytase, the enzyme that breaks down phyate, led to improved iron bioavailability. This clinical trial will attempt to demonstrate that this concept also works in humans
Interventions
Whole grain rye bread baked without sourdough fermentation (normal yeast-based fermentation)
Whole grain rye bread fermented with sourdough culture before baking
Sponsors
Study design
Eligibility
Inclusion criteria
* Healthy women under 50 years old
Exclusion criteria
* Pregnancy or breast feeding * Use of mineral or other dietary supplements * Use of medical or recreational drugs * Donation of blood within the previous 3 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum ferritin | 12 week values corrected for baseline |
| Serum transferrin receptor | 12 week values corrected for baseline |
| Haemoglobin | 12 week values corrected for baseline |