Healthy Subjects
Conditions
Brief summary
The main objective is to investigate gut microflora composition in relation to cardiometabolic risk markers, and to investigate the effects of 3 days intervention with a barley kernel based product on these variables.
Detailed description
100 subjects were invited to deliver faecal samples. From this cohort 40 subjects were chosen based on their gut microflora composition to participate in the Barley intervention.
Interventions
OTHERBarley kernel bread
3 days intervention with barley kernel bread
OTHERwhite wheat bread
3 days intervention with white wheat bread
Sponsors
Göteborg University
Lund University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
50 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* healthy men and women between 50-79 years and * BMI between 19-28.
Exclusion criteria
* fasting blood glucose concentrations \> 6,1 mmol/L, * known metabolic disorders or gastrointestinal diseases or other disorders that can interfere with the results of the study. * furthermore, the subjects should be non-smokers and * consume a normal (non-vegetarian) diet as is recommended by the Nordic dietary guidelines. * antibiotics or probiotics should not have been taken during four weeks prior to faeces donation.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in glucose regulation | Changes in fasting and postprandial blood glucose concentrations after 3 days intervention with a barley based bread in comparison to 3 days intervention with a white wheat based bread | blood glucose concentrations are measured fasting and postprandially a standardised breakfast after interventions with barley based bread and white wheat bread, respectively |
| Changes in colonic microbiota composition after intervention with barley | Changes in colonic microbiota composition after 3 days intervention with a barley based bread in comparison to 3 days intervention with a white wheat based bread | Gut microbiota composition are characterised after interventions with barley based bread and white wheat bread, respectively |
| nucleotide polymorphisms (SNP in TCF7L2) | at baseline | investigate nucleotide polymorphisms that associate with cardiometabolic traits, in particular the SNP in TCF7L2 |
Countries
Sweden
Outcome results
None listed