Asthma in the Elderly
Conditions
Brief summary
Asthma in the elderly is poorly understood, as most studies have not included this patient group. In a previous study of adults with asthma, choline supplementation had a positive effect on asthma symptoms and allowed to decrease asthma pharmacologic treatment. The present study is a randomized, double-blind, placebo-controlled, cross-over study of choline supplementation. The investigators will study the effect of choline 650 mg taken orally twice daily x 6 weeks versus placebo on asthma symptom scores (Asthma Control Test) and spirometric values (FEV1, FEV1/FVC, FEF25-75%). The investigators will also look at the effect of choline supplementation on peripheral blood eosinophils, serum immunoglobulin E (IgE) and homocysteine levels.
Interventions
DIETARY_SUPPLEMENTCholine
OTHERPlacebo
Sponsors
Rohr and Columbo Asthma, Allergy and Immunology Specialists, P.C.
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Asthma
Exclusion criteria
* No history of smoking more than 10 pack/years, * no gastrointestinal cancers, * no liver or kidney disease, * no bipolar disorder.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effect of choline supplementation on asthma symptoms measured by the Asthma Control Test | six weeks |
| Effect of choline supplementation on spirometric values (FEV1, FEV1/FVC, FEF25-75%) | six weeks |
Secondary
| Measure | Time frame |
|---|---|
| Effect of choline supplementation on peripheral blood eosinophils | six weeks |
| Effect of choline supplementation on serum IgE | six weeks |
| Effect of choline supplementation on serum homocysteine levels | six weeks |
Countries
United States
Outcome results
None listed