Choline

DIETARY_SUPPLEMENT16 trials

Sponsors

University of Colorado, Denver, Columbia University, University of North Carolina, Chapel Hill, The Cleveland Clinic, San Diego State University

Conditions

Alcohol-related Neurodevelopmental DisorderAlzheimer DiseaseAsthma in the ElderlyCannabis UseCardiovascular Risk FactorChild DevelopmentDietary ModificationExertional Rhabdomyolysis

Early Phase 1

CARNIVAL Study: Gut Flora Dependent Metabolism of Dietary CARNItine and Phosphatidylcholine and cardioVAscuLar Disease

Active, not recruitingNCT01731236

The Cleveland ClinicDietary Modification

Start: 2011-02-11End: 2029-12-01Target: 100Updated: 2026-03-23

Phase 1

Safety and Effectiveness of Taking Choline Supplements During Pregnancy for Improving Infant Brain Development

CompletedNCT00332124

University of Colorado, DenverChild Development, Pregnancy

Start: 2006-06-30End: 2017-03-31Updated: 2020-09-02

Choline Supplementation During Pregnancy: Impact on Attention and Social Withdrawal

CompletedNCT03028857

University of Colorado, DenverChild Development, Prenatal Stress

Start: 2017-06-12End: 2025-12-22Updated: 2026-01-07

Choline Effects - Pre-symptomatic AD

CompletedNCT05880849

Paul E SchulzAlzheimer Disease

Start: 2023-06-26End: 2025-10-10Updated: 2026-02-02

Maternal Choline Supplementation and Cannabis Use During Pregnancy: Impact on Early Brain Development

RecruitingNCT06379971

University of Colorado, DenverCannabis Use, Child Development

Start: 2024-11-25End: 2029-04-30Target: 140Updated: 2025-02-03

Phase 2

Choline Supplementation in Children With Fetal Alcohol Spectrum Disorders

CompletedNCT01911299

San Diego State UniversityAlcohol-related Neurodevelopmental Disorder, Fetal Alcohol Spectrum Disorders, Fetal Alcohol Syndrome +2

Start: 2013-05-31End: 2014-05-31Updated: 2014-08-01

Reverse Triple Negative Immune Resistant Breast Cancer

RecruitingNCT05076682

Fudan UniversityTriple-negative Breast Cancer

Start: 2022-06-30End: 2027-03-31Target: 80Updated: 2025-12-03

Phase 3

Asthma in the Elderly: A Study of Choline Supplementation

CompletedNCT02371993

Rohr and Columbo Asthma, Allergy and Immunology Specialists, P.C.Asthma in the Elderly

Start: 2015-01-31End: 2015-06-30Updated: 2015-10-29

Phase 4

Effect of Oral Choline Supplementation on Postoperative Pain

CompletedNCT00720343

Columbia UniversityInflammation, Postoperative Pain

Start: 2009-02-28End: 2012-12-31Updated: 2024-07-09

Unknown Phase

Nutritional Prevention of Exertional Muscle Dysfunction

CompletedNCT01722448

University of North Carolina, Chapel HillExertional Rhabdomyolysis, Muscle Dysfunction, Muscle Strength

Start: 2012-11-30End: 2015-08-31Updated: 2017-10-16

Synergy Between Choline and DHA

Cornell UniversityPregnancy

Start: 2017-10-05End: 2021-12-05Target: 40Updated: 2020-01-18

Short Term Choline and Cardiovascular Health

CompletedNCT03327805

Virginia Polytechnic Institute and State UniversityCardiovascular Risk Factor

Start: 2019-05-08End: 2023-11-21Updated: 2026-03-27

Choline Supplementation and Cardiovascular Health

CompletedNCT03646175

Virginia Polytechnic Institute and State UniversityCardiovascular Risk Factor

Start: 2018-09-24End: 2023-11-21Updated: 2026-03-27

Choline and Cardiometabolic Health

CompletedNCT04764162

Virginia Polytechnic Institute and State UniversityCardiovascular Risk Factor

Start: 2021-08-20End: 2023-11-21Updated: 2025-05-31

Choline Dose Ranging in Postmenopausal Women

RecruitingNCT06924541

Julie DumasMenopause

Start: 2024-09-01End: 2026-03-01Target: 20Updated: 2025-09-11

Choline and Brain Functioning in Postmenopausal Women

CompletedNCT07264257

University of VermontMenopause

Start: 2022-06-15End: 2025-03-01Updated: 2025-12-04

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Abstract PO1-14-07: Programme of mast cell subsets to potentiate breast cancer immunotherapy: from bed to bench to bed (the phase 2 platform RENAISSANCE trial)

Cancer Research2024-05-02

Prenatal choline supplementation improves biomarkers of maternal docosahexaenoic acid (DHA) status among pregnant participants consuming supplemental DHA: a randomized controlled trial

American Journal of Clinical Nutrition2022-05-1618 citations

l-Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in humans.

2018-12-10242 citations

Randomized, double-blind, placebo-controlled clinical trial of choline supplementation in school-aged children with fetal alcohol spectrum disorders.

2016-11-0252 citations

Exercise‐induced muscle damage in healthy men with low choline intake

The FASEB Journal2016-04-01

Asthma in the elderly: the effect of choline supplementation

Allergy Asthma and Clinical Immunology2016-03-116 citations