Traumatic Brain Injury
Conditions
Keywords
Amantadine hydrochloride, Rehabilitation, Acquired Brain Injury, TBI
Brief summary
Amantadine hydrochloride is one of the drugs given at rehabilitation programs to people who suffered Acquired Brain Injury in order to expedite recovery and improve functioning. A previous study examined the spatially asymmetric allocation of attention in patients with traumatic brain injury (TBI). Patients demonstrated significantly worse performance with leftward than with rightward cross-hemi field shifts of attention. This is reminiscence of neglect patients. This difference was significantly reduced during and following treatment. Our objective is to investigate whether Amantadine Hydrochloride is effective in improving allocation of spatial attention and improving function in people with Traumatic Brain Injury.
Interventions
Drug dosages: day 0-14 no drug will be given Days 15-21 100 mg Days 22-28 200 mg Days 29-42 400 mg Days 43-56 200 day 57-70 no drug will be given
Sponsors
Loewenstein Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
1. Aged 18-50 yrs 2. Patients who were diagnosed with a Diffuse Axonal Injury post TBI 3. Severity of injury was defined as moderate to severe 4. At least 3 months post injury 5. Sufficient cognitive abilities to learn and perform the computerised task.
Exclusion criteria
1. Pyramidal signs on neurological examination 2. Localised damage demonstrated on CT 3. Contra indication to Amantadine, post traumatic epilepsy, renal failure and patients with known sensitivity to Amantadine 4. Patients who were diagnosed with Parkinson's disease or has a first degree family who was diagnosed with Parkinson's.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The Posner Cueing Task | up to day 70 | The study paradigm is based on The Posner Cueing Task, a visual spatial attention task. Identification rates were measured after pre cuing attention to different visual field loci. After pre cuing to a locus 5 degrees into the left or right hemi field, target patterns were presented briefly at the cued location (valid) or on the opposite side (invalid) requiring an attentional shift |
Countries
Israel
Outcome results
None listed