Amantadine Hydrochloride

DRUG9 trials

Sponsors

Novartis, Methodist Rehabilitation Center, Wake Forest University Health Sciences, JFK Medical Center, Loewenstein Hospital

Conditions

AggressionBrain InjuryCOVID-19Cerebral PalsyDeliriumGlioblastoma MultiformeHealthyPosttraumatic Confusional State

Phase 1

Safety and Pharmacokinetic Effects of Oseltamivir Alone or in Combination With Amantadine

CompletedNCT00416962

NovartisHealthy

Start: 2006-08-31End: 2006-12-31Target: 18Updated: 2007-11-30

Phase 2

Effectiveness of Amantadine Hydrochloride for Treatment of Severe Traumatic Brain Injury (TBI)

CompletedNCT00970944

JFK Medical CenterTraumatic Brain Injury

Start: 2003-02-28End: 2010-03-31Updated: 2012-09-24

Study to Assess the Safety of Amantadine Hydrochloride (HCl) Intravenous (IV) Solution (MR-301) in Patients With Severe Traumatic Brain Injury (TBI).

Active, not recruitingNCT06253923

SHINKEI Therapeutics, IncTraumatic Brain Injury

Start: 2024-06-01End: 2025-08-31Target: 45Updated: 2025-07-15

Phase 3

The Use of Amantadine in the Prevention of Progression and Treatment of COVID-19 Symptoms

Independent Public Clinical Hospital No. 4 in LublinCOVID-19, SARS-CoV-2

Start: 2021-03-15End: 2022-05-31Target: 200Updated: 2021-08-13

Phase 4

Amantadine for Treatment of Symptoms of the Post-traumatic Confusional State

CompletedNCT00693121

Methodist Rehabilitation CenterDelirium, Posttraumatic Confusional State, Traumatic Brain Injury

Start: 2003-04-30End: 2019-03-31Updated: 2023-10-18

Effect of Amantadine Administration on Spatial Functioning Following Traumatic Brain Injury

Loewenstein HospitalTraumatic Brain Injury

Start: 2014-06-30End: 2018-12-01Target: 10Updated: 2018-08-08

Amantadine in Treating Cognitive & Motor Impairments in Adolescents and Adults With Cerebral Palsy

TerminatedNCT04273737

Columbia UniversityCerebral Palsy

Start: 2020-02-28End: 2022-02-22Updated: 2022-05-31

Unknown Phase

Amantadine for the Treatment of Traumatic Brain Injury Irritability and Aggression: A Multi-site Study

CompletedNCT00779324

Wake Forest University Health SciencesAggression, Brain Injury

Start: 2009-08-31End: 2013-05-31Updated: 2022-07-12

Acetyl-Amantadine as a Biomarker in Patients With Glioblastoma

RecruitingNCT04530006

CancerCare ManitobaGlioblastoma Multiforme

Start: 2020-12-02End: 2025-08-31Target: 20Updated: 2024-02-23

Related Papers

Efficacy of oral amantadine among patients hospitalised with COVID-19: A randomised, double-blind, placebo-controlled, multicentre study.

2023-03-156 citations

The use of amantadine in the prevention of progression and treatment of COVID-19 symptoms in patients infected with the SARS-CoV-2 virus (COV-PREVENT): Study rationale and design.

2022-04-0412 citations

Potential Impact of Amantadine on Aggression in Chronic Traumatic Brain Injury

Journal of Head Trauma Rehabilitation2017-09-0141 citations

Placebo-controlled trial of amantadine for severe traumatic brain injury.

2012-03-01503 citations

A randomized, crossover study to evaluate the pharmacokinetics of amantadine and oseltamivir administered alone and in combination.

2007-12-1243 citations