Type 2 Diabetes
Conditions
Keywords
Short fatty acids, 2-oleoyl glycerol, GLP-1 secretion, C8-diet oil, GIP secretion
Brief summary
This study compared the incretin-releasing effect of C8-diet oil and tributyrin with that of 20 ml olive oil on a molar basis in human volunteers.
Detailed description
A structured triglyceride (1,3-di-octanoyl-2-oleoyl-glycerol, called C8-diet oil), which upon digestion results in generation of two medium-chain fatty acids and 2-oleoyl-glycerol (2-OG), may lead to activation of GPR119 only, since medium fatty acids are poor agonists for fatty acid receptors.
Interventions
DIETARY_SUPPLEMENTTributyrin
a triglyceride containing three C4-acids
DIETARY_SUPPLEMENTC8-diet oil
a triglyceride containing 2 C8-fatty acids and one oleic acid at sn-2 position
DIETARY_SUPPLEMENTOlive oil
a triglyceride containing mostly three oleic acids
DIETARY_SUPPLEMENTCarrot
mainly water and glucose
Sponsors
University of Copenhagen
Glostrup University Hospital, Copenhagen
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
MALE
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Caucasian healthy male subjects * Body mass index (BMI) 19 to 25 kg/m2 * Informed consent
Exclusion criteria
* Anaemia * Diabetes mellitus * Gastrointestinal diseases or operations interacting with intestinal absorption
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| plasma GLP-1 | 2 hours postprandial |
| plasma GIP | 2 hours postprandial |
Secondary
| Measure | Time frame |
|---|---|
| plasma glucose | 2 hours postprandial |
| plasma insulin | 2 hours postprandial |
| plasma CCK | 2 hour postprandial |
| plasma neurotensin | 2 hour postprandial |
| plasma PYY | 2 hours postprandial |
Outcome results
None listed