Hypertension
Conditions
Keywords
Glu298Asp polymorphism, Blood pressure, Plasma NOx, Beetroot
Brief summary
The Glu298Asp polymorphism has been linked to increased risk of cardiovascular events, proposed to be due to reduced nitric oxide production by eNOS reported in some but not all studies. We hypothesise that beetroot-enriched bread interacts with the Glu298Asp polymorphism of the eNOS gene to lower blood pressure and increase plasma nitrate/nitrite, particularly in carriers of the T allele, which have been associated with lower eNOS activity and increased risk of hypertension.
Interventions
DIETARY_SUPPLEMENTBread
Sponsors
University of Reading
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
MALE
Age
18 Years to 64 Years
Healthy volunteers
Yes
Inclusion criteria
* Male * A signed consent form * Age 18-64 years * Body mass index - 18.5-30 kg/m2 * Non-smoking, healthy individuals * Normal blood pressure at screening (\< 150/90)
Exclusion criteria
* Subjects with anaemia * Sufferers of chronic illnesses * Individuals with food allergies * People with diabetes * People with coeliac disease * Women * Vegetarians
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postprandial blood pressure | 30 minute intervals for a period of 6 hours |
Secondary
| Measure | Time frame |
|---|---|
| Postprandial plasma NOx | 30 minute intervals for a total period of 6 hours |
Countries
United Kingdom
Outcome results
None listed