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Tryptophan Requirement of Healthy School Age Children

Tryptophan Requirement of Healthy School Age Children Determined by the Indicator Amino Acid Oxidation Method

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02018588
Enrollment
7
Registered
2013-12-23
Start date
2013-12-31
Completion date
2017-12-31
Last updated
2018-02-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

requirements, amino acid, tryptophan

Brief summary

Our objective is to determine the requirement for the amino acid tryptophan in school age children using the indicator amino acid technique.

Detailed description

Seven healthy children will participate in the study. The children will participate as an outpatient basis with study days carried out in the Physiological Research Unit at the Hospital of Sick Children, Toronto, Canada. Inclusion criteria include: being healthy, not taking any medications, no recent weight changes, no history of significant illness, willing to participate in the study. Exclusion criteria were the presence of illness, significant weight change, not acceptance of the diet. Prior to enrolment, each subject will have to fill 3 days food record form to ensure his or her normal dietary behavior. The study will be explained to subjects and their parents/guardians, benefits and potential risks will be explained as well and written assent, from the children, and consent from parents will be obtained. Subjects will receive financial compensations. Each subject will receive compensation for participation. Each parent/guardian will be reimbursed for the transpiration/parking expenses and a meal each study day.

Interventions

DIETARY_SUPPLEMENTtryptophan

graded levels of tryptophan will be given to each subject

Sponsors

The Hospital for Sick Children
Lead SponsorOTHER

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
6 Years to 10 Years
Healthy volunteers
Yes

Inclusion criteria

* Healthy children age 6-10 inclusive

Exclusion criteria

* significant recent illness

Design outcomes

Primary

MeasureTime frameDescription
Requirement of tryptophan in school age children4 hoursBy collection of stable isotope labeled CO2 from the indicator amino acid phenylalanine in response to different intake levels of tryptophan we will be able to determine tryptophan requirements.

Countries

Canada

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 4, 2026