Atrial Fibrillation
Conditions
Keywords
Atrial fibrillation, Propafenone, Dronedarone
Brief summary
the purpose of this study is to compare the ability of propafenone and dronedarone to maintain sinus rhythm after DC cardioversion
Detailed description
Atrial fibrillation is the most common arrhythmia requiring continuous therapy. Conversion to and maintenance of sinus rhythm is important. Propafenone and dronedarone has been used as treatment for maintenance of sinus rhythm after DC cardioversion. But there are no direct comparison study. The purpose of this study is to compare the ability of propafenone and dronedarone to maintain sinus rhythm after DC cardioversion.
Interventions
DRUGPropafenone
DRUGDronedarone
Sponsors
Samsung Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* a patient with persistent atrial fibrillation who received successful DC cardioversion
Exclusion criteria
* prior amiodarone use * NYHA class III or IV heart failure * Left ventricular ejection fraction \< 35% * second or third AV block * sick sinus syndrome * heart rate \< 50 beat per minute * myocardiac infarction within 3 months * pregnant women * severe hepatic dysfunction * QT prolongation \> 500ms or PR interval \> 180ms * history of hypersensitivity for drug
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| recurrence of atrial fibrillation | 6 month |
Countries
South Korea
Outcome results
None listed