Cardiovascular Disease
Conditions
Brief summary
It is important to identify and evaluate foods, such as strawberries, that can improve established and emerging cardiovascular risk factors, such as postprandial lipid and glycemic responses, and vascular health. Postprandial derangements may affect multiple metabolic pathways that lead to increased arterial stiffness. Research has demonstrated the potential of strawberries to ameliorate postprandial responses to a high fat/high glucose meal. Further research is needed to demonstrate this effect in better controlled clinical studies and explore whether metabolic effects lead to improved arterial health. The investigators propose to examine the effects of adding 40 g of freeze-dried strawberry powder to a high fat/high glucose meal on postprandial cardiovascular risk factor including lipids, insulin, glucose, and arterial stiffness and central blood pressure. The investigators hypothesize that the bioactive components of strawberry powder will attenuate postprandial lipemic and glycemic responses, as well as improve measures of arterial health.
Interventions
DIETARY_SUPPLEMENTStrawberry Meal
High-fat meal (50 g total fat) with 40 g freeze dried strawberry powder
DIETARY_SUPPLEMENTControl Meal
High-fat meal (50 g total fat) with a matched placebo powder containing no strawberry bioactives
Sponsors
California Strawberry Commission
Penn State University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
20 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* 20-50 years of age * LDL-C below 160 mg/dL * Triglycerides below 350 mg/dL * No stage II hypertension (BP below 160/100 mmHg) * Not taking medication for elevated lipids, blood pressure, or glucose
Exclusion criteria
* Allergies to strawberries * Known intolerance to high fat meals * History of cardiovascular disease, kidney disease, diabetes or inflammatory diseases such as GI disorders and arthritis * Use of non-steroidal anti-inflammatory or immunosuppressant drugs * Conditions requiring the use of steroids * Use of medication or supplements for elevated lipids, blood pressure or glucose
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change from baseline in postprandial central blood pressure and arterial stiffness | 2 and 4 hours |
Secondary
| Measure | Time frame |
|---|---|
| Postprandial changes in insulin | 0, 0.5, 1, 2, and 4 hours |
| Postprandial changes in glucose | 0, 0.5, 1, 2, and 4 hours |
| Postprandial changes in markers of inflammation/oxidative stress | 0, 0.5, 1, 2, and 4 hours |
| Change from baseline in postprandial triglycerides at 0.5, 1, 2, and 4 hours | 0.5, 1, 2, and 4 hours |
Countries
United States
Outcome results
None listed