Congenital Hyperinsulinism (CHI), Beckwith-Wiedemann Syndrome, Insulinoma
Conditions
Keywords
Hypoglycemia, Hyperinsulinism (HI), F-DOPA, PET, 18-F DOPA, 18F-L-Fluoro-DOPA, 18F-fluoro-L-dihydroxyphenylalanine, focal pancreatic lesions, congenital hyperinsulinism, Beckwith Wiedemann Syndrome, insulinoma, Hyperinsulinemic Hypoglycemia, F-DOPA PET, CHI (Congenital hyperinsulinism)
Brief summary
This purpose of this study is to determine the ability of an 18F-fluoro-L-dihydroxyphenylalanine (18F-DOPA) PET (Positron Emission Tomography) scan to detect a focal lesion of hyperinsulinism and determine the location in patients with congenital hyperinsulinism, Beckwith Wiedemann Syndrome and suspected insulinoma. Safety data will be collected.
Detailed description
Patients with hyperinsulinemic hypoglycemia are at risk for neurological damage due to hypoglycemia. Early surgical intervention can be preventative. F-DOPA PET may be able to detect of a focal lesion prior to surgical intervention and be used during surgical planning to guide the surgical procedure.
Interventions
DRUG18F-DOPA
18F-DOPA is a PET (Positron Emission Tomography) scan radiotracer.
Sponsors
Children's Hospital of Philadelphia
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Subjects of any age with hyperinsulinemic hypoglycemia, diagnosed by a fasting test and/or response to glucagon stimulation. * Subjects who are eligible for pancreatic surgery regardless of prior pancreatic surgery
Exclusion criteria
* Pregnant or lactating females * Any other major illness or condition that in the investigator's judgment will substantially increase the risk associated with the subject's participation in this study * Subjects who are not a candidate for pancreatic surgery
Countries
United States
Contacts
Primary ContactSusan Becker, RN, BSN, CCRC
Backup ContactLisa States, MD
Outcome results
None listed