Impact of Probiotics in Modulation of Intestinal Microbiota

Impact of Probiotics in Modulation of Intestinal Microbiota of Patients Undergoing a Resection Colonic

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01895530

Enrollment

Registered

2013-07-10

Start date

2010-07-31

Completion date

2012-05-31

Last updated

2013-07-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal Cancer

Keywords

Probiotics, colorectal cancer, postoperative infection, immune function, bacterial translocation, gastrointestinal surgery

Brief summary

The investigators would study about impact of the administration of probiotics in the intestinal mucosa of patients undergoing resection colic, by evaluating cytokine profile by quantitative real time PCR. The investigators believe that patients who use probiotic preoperative would provide cytokine profile less inflammatory than those of the control group.

Detailed description

Samples of colorectal cancer-free mucosa derived from patients who underwent surgical resection were investigated. Quantitative real-time polymerase chain reaction (RT-qPCR) was used to determine expression levels of the following genes: IL10, IL1B, IL23A, TNF, IL12B, INFG, IL17A.

Interventions

DIETARY_SUPPLEMENTSaccharomyces boulardii

The patients received one oral lyophilized yeast capsule, each of which contains 100 mg (0,5 x 109 cfu/g) of Saccharomyces boulardii (Merck S.A., Biocodex, Beauvais, French), once a day. The treatment started at least seven days before surgery and stopped on the operation day.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* if he or she were older than 18 years * intended to undergo elective CRC resection at UFMG Hospital

Exclusion criteria

* Patients were excluded if they were not able to receive the probiotics seven days before the operation * if colon resection was not performed due to changes in operation strategy, or if they discontinued probiotic use on their own or * if they removed their consent.

Design outcomes

Primary

Measure	Time frame	Description
Difference in gene expression of citokynes	15 days	Colonic mucosal specimens were analyzed to determine the mucosal expression proﬁles of IL1B, IL12B, IL10, IL23A, INFG, IL17A and TNF.

Secondary

Measure	Time frame	Description
Postoperative complications	30 days	Postoperative complications assessed up to 30 days

Countries

Brazil

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026