Comparison of Dietary Fats on Vascular Parameters

Acute Effects of Dietary Fats on Postprandial Vascular Function in Healthy Individuals: Pilot Double Blind, Randomized, Controlled Trial

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01876394

Acronym

COIL

Enrollment

Registered

2013-06-12

Start date

2014-06-30

Completion date

2016-06-30

Last updated

2016-03-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

Healthy, Arterial Stiffness, Blood Pressure, Blood Glucose, Vascular Function

Brief summary

The purpose of the study is to examine the effect of consuming 50g of fat from 5 different sources (coconut, canola, grapeseed, chia, and butter) on arterial stiffness, blood pressure and blood glucose levels. It is hypothesized that butter will have the most detrimental effect on acute vascular function. Canola, grapeseed and chia oil with their decreased content of SFA are hypothesized to impair vascular function to a lesser extent.

Interventions

OTHERCoconut Oil

Shake with 50 g Coconut oil

OTHERCanola Oil

Shake with 50 g Canola oil

OTHERGrapeseed Oil

Shake with 50 g Grapeseed oil

OTHERChia Oil

Shake with 50 g Chia oil

OTHERButter

Shake with 50 g Butter

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy * Age 18-65 years * BMI \< 30 kg/m2 * Brachial systolic blood pressure ≤ 140 mmHg * Brachial diastolic blood pressure ≤ 90 mmHg

Exclusion criteria

* Women of childbearing age must not be pregnant or breastfeeding at the time of the study * BMI \>35kg/m2 * Hypertensive as defined by brachial SBP \>140mmHg and/or DBP \>90mmHg * Sensitivity to the study product or its sources * Presence of chronic conditions or illnesses * Having any gastrointestinal complication or condition * Chronic use of dietary supplements that alter fat absorption

Design outcomes

Primary

Measure	Time frame
To compare 5 different dietary fat sources in a liquid meal on postprandial changes in augmentation index (AIx)	5 separate mornings, measurements taken at baseline and at 60, 120 and 180 minutes

Secondary

Measure	Time frame
To investigate whether these dietary fat sources will result in blood pressure changes and a differential glycemic response	5 separate mornings, blood pressure measurements will be taken at baseline, 60, 120 and 180 minutes. Blood samples will be taken at baseline 15, 30, 45, 60, 90 and 120 minutes

Countries

Canada

Contacts

Primary ContactThanh Ho, BSc

hoho@smh.ca416-864-6060

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026