Obesity, Weight Loss
Conditions
Keywords
Obesity, Weight Loss, Body Weight Change, Taste, Taste Phenotype, Lifestyle Intervention
Brief summary
Individual food preferences are not considered in designing weight-loss therapies. This project will determine if short-term weight-loss is improved by matching participants with diets that reflect their genetically-determined food preferences.
Detailed description
Dislike of the diet is a common complaint in weight loss therapy that contributes to poor outcomes. Ironically, individual food preferences are rarely taken into account in designing weight-loss interventions. In the proposed research, we will utilize genetically-determined differences in food preferences, indexed by PROP bitter taste phenotype to develop a novel approach to weight loss therapy. The overall goal of this project is to determine if weight loss following a 6 month intervention can be substantially improved by matching participants with diets that reflect their genetically-determined food preferences. The study is designed as a randomized clinical weight-loss intervention trial in women in which PROP non-tasters and super-tasters. will be randomized to either the low-carbohydrate or the low-fat diet condition
Interventions
BEHAVIORALLow-Carbohydrate Diet
Participants are provided with a 6-month standard lifestyle intervention where carbohydrate intake is limited to 50 g/day. There is no calorie restriction for participants following the Low-Carbohydrate diet. Gradual increase in physical activity across the trial to \> 40 min per day, 5 times/week.
BEHAVIORALLow-fat Diet
Participants are provided with a 6-month standard lifestyle intervention. They will follow an energy restricted, low-fat diet where the daily energy consumption target is 1,200- 1,500 kilocalories/d. The fat intake target is 28% or less of daily kilocalories. Gradual increase in physical activity until participants are active at least 40 min per day, 5 times/week.
Sponsors
Rutgers University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
Body mass index (BMI) between 27 and 40 kg/m squared No weight loss for 3 months prior to the study Stable hypertension, dyslipemia or Type 2 diabetes - with permission from primary care provider Oral therapy to treat Type 2 diabetes - with permission from primary care provider. Able to walk 2 block without stopping
Exclusion criteria
Pregnant, lactating or planning to become pregnant during the trial History of cardiovascular disease (infarct, angina, arrhythmia or stroke) Recent chemotherapy or radiation therapy Liver, renal or thyroid disease Concurrent or recent (last 6 months) participation in any other weight loss intervention Insulin injection Medications to control appetite or weight Major psychiatric illnesses
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Weight Loss | 0, 3 months, and 6 months | Change in weight (Kg) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Diet | 0, 3 months, and 6 months | 4-day diet records will be assessed for kilocalories and macronutrients |
Other
| Measure | Time frame | Description |
|---|---|---|
| Physical Activity | 0, 3 months, and 6 months | Physical activity energy expenditure will be assessed by activity monitor |
| Eating Attitudes | 0, 3 months, and 6 months | Eating attitudes will be assessed with the Three-Factor Eating Questionnaire |
Countries
United States
Outcome results
None listed