Osteoporosis
Conditions
Keywords
Vitamin D, Serum sclerostin, Serum dickkopf1
Brief summary
The purpose of this study is to compare the effect of inactive and active vitamin D on serum sclerostin and dickkopf1 levels.
Interventions
Sponsors
Seoul National University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
20 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy male volunteer older than 20 years
Exclusion criteria
* Subjects with bone and mineral metabolism disorders * Subjects with kidney or liver diseases * Subjects with uncorrectable hypercalcemia or hypocalcemia * Subjects with chronic gastrointestinal disorders or malabsorption * Subjects taking medication related to bone loss
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change of serum sclerostin level | 8 weeks later |
| Change of serum Dickkopf1 level | 8 weeks later |
Secondary
| Measure | Time frame |
|---|---|
| Change of serum c-telopeptide level | 8 weeks later |
| Change of serum bone-specific alkaline phosphatase level | 8 weeks later |
| Change of serum calcium level | 8 weeks later |
| Change of serum parathyroid hormone level | 8 weeks later |
Countries
South Korea
Contacts
Primary ContactChan Soo Shin, MD, PhD
Backup ContactJung Hee Kim, MD
Outcome results
None listed