Comparison the Effects of Dexamethasone and Loteprednol on Epithelial Healing

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01724892

Enrollment

Registered

2012-11-12

Start date

2012-11-30

Completion date

2013-09-30

Last updated

2014-03-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Epithelial Defect After Phototherapeutic Keratectomy

Brief summary

Corticosteroid has been used for the treatment after phototherapeutic keratectomy (PRK). Dexamethasone, a potent steroid can retard the corneal epithelial healing rate and has numerous serious complications, especially glaucoma. Loteprednol, a new generation of corticosteroid has less potency than dexamethasone and was proposed to has less side effect regarding intraocular pressure (IOP) elevation. Therefore, Investigators would like to compare the effect of dexamethasone and loteprednol on corneal epithelial healing rate after PRK and risk of glaucoma.

Interventions

DRUGDexamethasone

DRUGLoteprednol etabonate

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 40 Years

Healthy volunteers

Inclusion criteria

* the patient with epithelial defect after phototherapeutic keratectomy

Exclusion criteria

* the patient with systemic disease such as diabetes and connective tissue disease * the patient with ocular surface disease such as dry eye and recurrent corneal erosion

Design outcomes

Primary

Measure	Time frame
corneal epithelial healing	1 month

Secondary

Measure	Time frame
intraocular pressure	6 month

Countries

Thailand

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026