Metabolic Syndrome
Conditions
Brief summary
This study aims at investigating the impact of colonic fermentation of intrinsic indigestible carbohydrates in cereal whole kernels after three days consumption, on metabolic variables and cognition. The study is performed in healthy, normal to slightly over-weight test subjects.
Interventions
OTHERtest meal
OTHERreference meal
Sponsors
Lund University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
50 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* BMI 19-28 kg/m2
Exclusion criteria
* gastrointestinal diseases * metabolic disorders * tobacco/snuff user * antibiotic/probiotic treatment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Area under the plasma concentration versus time curve (AUC) of the test meal | Post-prandially after breakfast, 0-150 min | The differences in AUC between different risk markers, assessed in plasma or serum,after intake of the test meal in comparison to the reference meal is measured. Example of variables measured are glucose, insulin, appetite hormones, inflammatory markers, markers of colonic fermentation. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cognitive performance | Post-prandially after breakfast, 0-210 min | The cognitive performance of the test subjects is measured to investigate work memory and specific attention. |
| Subjective satiety | post-prandially after breakfast, 0-150 min | The subjective sensation of satiety, hunger and desire to eat is measured using a questionnaire. |
Countries
Sweden
Outcome results
None listed