Hypertension
Conditions
Keywords
Beetroot, Blood pressure, Vascular function
Brief summary
Dietary nitrate is known to lower blood pressure. Beetroot is a rich source of nitrate and could therefore be an important dietary component in the management of hypertension and cardiovascular disease, however consumption is relatively low. We evaluated the effects of beetroot enriched bread ingestion on acute microvascular reactivity, arterial stiffness and blood pressure response in healthy men.
Interventions
DIETARY_SUPPLEMENTBread
Sponsors
University of Reading
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
MALE
Age
18 Years to 64 Years
Healthy volunteers
Yes
Inclusion criteria
* Male * A signed consent form * Age 18-64 years * Body mass index - 18.5-30 kg/m2 * Non-smoking, healthy individuals * Normal blood pressure at screening (\< 150/90)
Exclusion criteria
* Subjects with anaemia * Sufferers of chronic illnesses * Individuals with food allergies * People with diabetes * People with coeliac disease * Women * Vegetarians
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Vascular reactivity | Change from baseline at 2, 4 and 6 hours after bread consumption | Forearm blood flow by Laser Doppler Imaging with iontophoresis |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Arterial stiffness | Change from baseline at 2, 4 and 6 hours after bread consumption | Pulse wave analysis (PWA) and velocity (PWV) |
| Blood pressure | Change from baseline at 30 minute intervals for 7 hours | By ambulatory blood pressure monitor |
| Plasma nitrate | Every 30 minutes for 7 hours | — |
| Plasma nitrite | Every 30 minutes for 7 hours | — |
Countries
United Kingdom
Outcome results
None listed