Effect of Hyoscine and Promethazine on Labor Pain

Principal Investigator

Status

Completed

Phases

Phase 2Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01644838

Enrollment

Registered

2012-07-19

Start date

2010-08-31

Completion date

2011-04-30

Last updated

2012-07-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Labor Pain

Keywords

Hyoscine,, Promethazine,, The first stage of labor,, Labor pain

Brief summary

It is always considered to shorten the duration of delivery without compromising the mother and fetus by obstetrics. Hyoscine and Promethazine are used widely in hospital and research is very limited, with conflicting results regarding the efficacy of these two drugs. So the investigators decided to compare of effect of hyoscine N-butyl bromide and Promethazine on length of active phase of the first stage of labor.

Interventions

DRUGHyoscine

The samples were randomly allocated to inject of 20 mg of hyoscineIM in dilatation 3-5cm.

DRUGPromethazine

The samples were randomly allocated to inject of 25 mg of promethazine IM in dilatation 3-5cm.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

* 18-35 yrs, * primiparous, * having single fetus with cephalic presentation, gestational age 37-42 weeks, * having no medical diseases, * having no history of hospitalization due to psychological diseases, * having no addiction to cigarette, * having no complications during pregnancy such as hypertension, * BMI\< 26

Exclusion criteria

* bleeding * CPD * use of PG or Oxytocin * fetus distress

Design outcomes

Primary

Measure	Time frame
Effect of Hyoscine and Promethazine on labor pain	up to 9 months

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026