Promethazine

DRUG17 trials

Sponsors

Sanofi-Aventis Recherche & Developpement, University of New Mexico, Vanderbilt University, University of California, Irvine, Shahid Beheshti University

Conditions

Acute lymphocytic leukaemia- Acute myeloid leukaemia refractory - Myelodysplastic syndrome - Blastic plasmacytoid dendritic cell neoplasiaAmbulatory Gynecological Laparoscopic ProceduresAnxiety DisordersChronic Hepatitis C Infection With Hepatic ComaConscious SedationCrohn's DiseaseDementiaDepression

Phase 1

An open-label, first-in-human, dose-escalation/expansion study of SAR443579 administered as single agent by intravenous infusion in adult and pediatric participants with relapsed or refractory acute myeloid leukemia (R/R AML), B-cell acute lymphoblastic leukemia (B-ALL), high risk-myelodysplasia (HR-MDS), or blastic plasmacytoid dendritic cell neoplasm (BPDCN)

CompletedCTIS2023-508357-58-00

Sanofi-Aventis Recherche & DeveloppementAcute lymphocytic leukaemia- Acute myeloid leukaemia refractory - Myelodysplastic syndrome - Blastic plasmacytoid dendritic cell neoplasia

Start: 2022-07-04End: 2025-03-12Target: 57Updated: 2025-06-23

Phase 2

Sunitinib or Cediranib for Alveolar Soft Part Sarcoma

CompletedNCT01391962

National Cancer Institute (NCI)Sarcoma, Alveolar Soft Part

Start: 2011-07-18End: 2026-01-16Updated: 2026-02-02

Effect of Hyoscine and Promethazine on Labor Pain

CompletedNCT01644838

Mashhad University of Medical SciencesLabor Pain

Start: 2010-08-31End: 2011-04-30Updated: 2012-07-20

Study of Promethazine for Treatment of Diabetic Gastroparesis

TerminatedNCT02130622

Dartmouth-Hitchcock Medical CenterDiabetic Gastroparesis

Start: 2014-07-31End: 2015-05-14Updated: 2018-08-07

Fundamental Modification of the Gut Microbiota in the Treatment of Refractory Crohn's Disease

CompletedNCT02765256

University of PennsylvaniaCrohn's Disease

Start: 2016-08-31End: 2018-12-31Updated: 2024-02-06

Phase 3

Effects of Oral Midazolam in Comparison Promethazine With Nitrous Oxide for Uncooperative Children

Shahid Beheshti UniversityConscious Sedation

Start: 2009-06-30End: 2010-05-31Target: 20Updated: 2010-05-07

Promethazine vs. Lorazepam for Treatment of Vertigo

CompletedNCT01827293

Shahid Beheshti University of Medical SciencesPeripheral Vertigo.

Start: 2013-04-30End: 2013-06-30Updated: 2013-06-14

Pharmacovigilance in Gerontopsychiatric Patients

TerminatedNCT02374567

Hannover Medical SchoolAnxiety Disorders, Dementia, Depression +2

Start: 2015-01-31End: 2017-06-28Updated: 2018-02-28

Phase 4

A RCT of Ondansetron and Promethazine in the Treatment of Nausea and Vomiting in the Emergency Department

CompletedNCT00429832

University of New MexicoNausea, Vomiting

Start: 2003-10-31End: 2005-11-30Target: 120Updated: 2007-02-01

Adjunct Sedatives in Endoscopic Ultrasound (EUS) and Endoscopic Retrograde Cholangiopancreatography (ERCP) Procedures

CompletedNCT00937924

University of California, IrvineEndoscopic Retrograde Cholangiopancreatography (ERCP), Endoscopic Ultrasound (EUS)

Start: 2008-02-29End: 2012-06-30Updated: 2024-02-26

Aprepitant Versus Ondansetron in Preoperative Triple-therapy Treatment of Nausea and Vomiting

CompletedNCT01474915

Sergio BergeseNausea, Postoperative Nausea and Vomiting (PONV)

Start: 2007-06-30End: 2013-04-30Updated: 2013-12-03

Single Dose Pharmacokinetics of Suboxone Study in Hepatic Impaired Subjects

CompletedNCT01846455

Indivior Inc.Chronic Hepatitis C Infection With Hepatic Coma, Hepatic Failure, Hepatic Impairment

Start: 2012-09-30End: 2013-05-31Updated: 2016-10-24

Countermeasures to Reduce Sensorimotor Impairment and Space Motion Sickness Resulting From Altered Gravity Levels

CompletedNCT02136420

Faisal_Karmali@MEEI.HARVARD.EDUVestibular

Start: 2014-06-30End: 2016-12-31Updated: 2018-01-08

Treatment of Pruritus With Intramuscular Promethazine

CompletedNCT04805073

University of FloridaPregnancy Related, Pruritus

Start: 2021-08-09End: 2024-05-30Updated: 2025-05-04

Unknown Phase

Comparison of Ondansetron, Metoclopramide and Promethazine for the Treatment of Nausea and Vomiting in the Adult ED

TerminatedNCT00655642

Vanderbilt UniversityNausea

Start: 2007-03-31End: 2008-10-31Updated: 2013-10-30

Efficacy of Low Dose Promethazine for Postoperative Nausea and Vomiting

TerminatedNCT01159548

Women's College HospitalAmbulatory Gynecological Laparoscopic Procedures

Start: 2010-07-31End: 2012-07-31Target: 400Updated: 2011-07-27

Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis

CompletedNCT02625181

Vanderbilt UniversityPostoperative Nausea and Vomiting

Start: 2016-07-31End: 2017-11-30Updated: 2019-03-07

Related Papers

Abstract CT168: Randomized phase 2 trial of sunitinib or cediranib in alveolar soft part sarcoma

Cancer Research2022-06-15

Cediranib in patients with alveolar soft-part sarcoma (CASPS): a double-blind, placebo-controlled, randomised, phase 2 trial.

2019-05-3166 citations

Pharmacokinetics of Sublingual Buprenorphine and Naloxone in Subjects with Mild to Severe Hepatic Impairment (Child-Pugh Classes A, B, and C), in Hepatitis C Virus-Seropositive Subjects, and in Healthy Volunteers.

2015-08-0121 citations