A Study of the Effects of Fish Protein Intake on Glucose Regulation in Overweight and Obese Adults.

A 8 wk Study to Compare the Effects of Proteins Various Fish Species (Salmon, Herring, Cod) and Milk on Glucose Regulation in Overweight and Obese Adults.

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01641055

Acronym

FISK3

Enrollment

Registered

2012-07-16

Start date

2012-07-31

Completion date

2012-11-30

Last updated

2022-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity, Overweight

Brief summary

The purpose of this study is to compare the possible health benefits of intake of proteins from salmon, herring, cod and milk on glucose tolerance in overweight and obese adults. Overweight and obese subjects often have reduced glucose tolerance, and previous findings from a study on cod proteins suggested that glucose tolerance was improved.

Detailed description

Participants receive 2.5g protein per day for 8 weeks as tablets.

Interventions

DIETARY_SUPPLEMENTCod protein

2.5g cod protein per day for 8wk.

DIETARY_SUPPLEMENTSalmon protein hydrolysate

2.5g salmon protein hydrolysate per day for 8wk.

DIETARY_SUPPLEMENTHerring protein hydrolysate

2.5g herring protein hydrolysate per day for 8wk.

DIETARY_SUPPLEMENTMilk protein

2.5g milk protein per day for 8wk.

Study design

Allocation

RANDOMIZED

Intervention model

FACTORIAL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 69 Years

Healthy volunteers

Yes

Inclusion criteria

* BMI above 27 kg/m2 * healthy

Exclusion criteria

* fasting blood glucose above 7 mM * medication that affects blood glucose, lipids and inflammatory status * pregnancy or breastfeeding * allergies to fish or milk * intentional weight loss and large fluctuation in body weight * a high consumption of fish * an extreme diet * use of fish oil, n-3 or multivitamin supplements

Design outcomes

Primary

Measure	Time frame	Description
Glucose regulation	8 weeks	Glucose will be measured in fasting and postprandial samples

Secondary

Measure	Time frame	Description
Changes in serum insulin, insulin C-peptide, non-esterified fatty acids, lipids, adiponectin, leptin and fatty acid composition	8 weeks	—
Changes in serum and urine concentrations of amino acids and their metabolites	8 weeks	—
Changes in serum concentrations of vitamins	8 weeks	—
Comparisons of metabolites and co-factors involved in one-carbon metabolism in serum and urine	8 weeks	Concentrations of relevant metabolites and co-factors were measured in serum and urine

Countries

Norway

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 3, 2026