Graves Disease
Conditions
Keywords
hyperthyroidism, radio-iodine, I-131, methimazole, graves disease
Brief summary
Iodine therapy is the best treatment for graves disease.Most patients receive methimozale prior to radio-iodine treatment. This may decrease treatment response to iodine therapy. Some physicians advice to discontinue methimazole 3 days before radioiodine therapy and others prefer longer off - methimazole period which bothers most patients. This study aimed to evaluate optimum time for methimazole discontinuation in graves disease.
Interventions
DRUGMethimazole
Methimazole was stopped 24-48 before radio-iodine therapy
Sponsors
Mashhad University of Medical Sciences
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* age 18-65 * graves disease(TSH\<0.1 &increased FT4 & positive TSI * one or more bartlena criteria for radio-iodine therapy * 24 hour RAIU\>25% * euthyroidism after methimazole treatment
Exclusion criteria
* pregnancy or lactation * moderate or severe graves ophthalmopathy * CHF or coronary heart disease * palpable thyroid nodule * lithium or amiodarone or lugol or ipodate treatment * recent imaging with contrast agent * very large goiter(more than 150 gram)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| thyroid function tests over one year after radioiodine therapy | months 1 , 3 ,6,9,12 | thyroid function test may change over one year . In order to consider the patients as cured ,thyroid function tests should reveal hypothyroidism or euthyroidism . In order to rule out temporary hypothyroidism the tests should be repeated after 6 months of radioiodine therapy. |
Countries
Iran
Outcome results
None listed