Glycemic Response After Palaeolithic-type Meals

Glycemic Response After Two Palaeolithic-type Meals Compared to a Modern-type Meal Composed According to WHO Guidelines

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01418573

Enrollment

Registered

2011-08-17

Start date

2011-08-31

Completion date

2011-10-31

Last updated

2013-08-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Glycemic Index of a Meal

Keywords

glucose, insulin, post prandial

Brief summary

The objective of the study is to show post-prandial benefits of Palaeolithic-type meals as compared to a meal constructed along the lines of the WHO dietary recommendations.

Detailed description

The effects of this set of meals will be assessed with respect to blood * blood glucose * plasma insulin * satiety scores * plasma gut hormones It is hypothesised that lower post prandial blood glucose concentration, a lower insulin response and increased satiety will be seen after the Palaeolithic meals compared with a reference meal

Interventions

OTHERPalaeolithic meal 1

Based on estimated ratios for protein, fat and carbohydrates that are typical of Hunter-Gatherers and does not contain ingredients that were not available in pre-neolithic times

OTHERPalaeolithic meal 2

Based on WHO dietary guidelines for protein, fat and carbohydrate but does not contain ingredients that were not available in pre neolithic times

OTHERReference meal

Based on WHO dietary guidelines for protein, fat and carbohydrate.

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

MALE

Age

18 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* male * ≥ 18 and ≤ 60 years old * Body mass index (BMI) ≥ 18 and ≤ 27.0 kg/m2 * Apparently healthy * Not smoking * A fasting blood glucose value within the normal reference value

Exclusion criteria

\- No prescribed medication

Design outcomes

Primary

Measure	Time frame	Description
Blood glucose	0-2 hours	positive incremental area under the concentration versus time
Plasma insulin	0-2 hours	net incremental area under the curve
Peak blood glucose	0-2 hours	maximal blood glucose value

Secondary

Measure	Time frame	Description
Satiety scores	0-2 hours	area under the curve
Gut hormone panel	0-3 hours	Average concentration over time

Countries

United Kingdom

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026